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Klara Sjögren
Forskare
Avd för invärtesmedicin och kliniskOm Klara Sjögren
Docent i molekylär medicin och forskare vid avdelningen för invärtesmedicin och klinisk nutrition. Undervisar på dietistprogrammet.
Forskning
Klara forskar på osteoporos (benskörhet) som är ett allvarligt hälsoproblem som leder till mycket lidande för patienten och höga kostnader för samhället. Skelettet är en dynamisk vävnad som ständigt bryts ner och återbildas under påverkan av faktorer, dels lokalt i ben och benmärg och systemiskt, i samspel med kroppens övriga organ. Tarmfloran påverkar nedbrytning av föda och utsöndring av olika substanser från tarmen. Klaras forskning fokuserar på samband mellan tarmfloran och benmassan och hur förändringar i tarmflorans sammansättning och metabolism påverkar benhälsa.
Pågående doktorandprojekt
Huvudhandledare: Lina Lawenius
Biträdande handledare: Hannah Colldén
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Identification of three bacterial species associated with increased appendicular lean mass: the HUNT
study
Louise Grahnemo, Maria Nethander, E. Coward, M. E. Gabrielsen, S. Sree, J. M. Billod, Klara Sjögren, L. Engstrand, K. F. Dekkers, T. Fall, A. Langhammer, K. Hveem, Claes Ohlsson
Nature Communications - 2023 -
Bone-Derived IGF-I Regulates Radial Bone Growth in Adult Male
Mice
Johan Svensson, Klara Sjögren, Lina Lawenius, A. Koskela, J. Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Endocrinology - 2023 -
Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone
mass
Lina Lawenius, C. Cowardin, Louise Grahnemo, Julia Scheffler, Karin Horkeby, Cecilia Engdahl, Jianyao Wu, Liesbeth Vandenput, A. Koskela, J. Tukkanen, E. Coward, K. Hveem, A. Langhammer, Sanna Abrahamsson, J. I. Gordon, Klara Sjögren, Claes Ohlsson
Gut Microbes - 2023 -
Development of a synbiotic that protects against ovariectomy-induced trabecular bone
loss
Lina Lawenius, Karin L. Gustafsson, Jianyao Wu, Karin H. Nilsson, Sofia Moverare-Skrtic, E. M. Schott, M. J. Soto-Giron, G. V. Toledo, Klara Sjögren, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2022 -
Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment in male
mice
Karin L Horkeby, Helen H. Farman, Sofia Movérare-Skrtic, Vikte Lionikaite, Jianyao Wu, Petra Henning, Sara H Windahl, Klara Sjögren, Claes Ohlsson, Marie K Lagerquist
Scientific Reports - 2022 -
A probiotic mix partially protects against castration-induced bone loss in male
mice
Lina Lawenius, Hannah Colldén, Karin L Horkeby, Jianyao Wu, Louise Grahnemo, Liesbeth Vandenput, Claes Ohlsson, Klara Sjögren
Journal of Endocrinology - 2022 -
Mild stimulatory effect of a probiotic mix on bone mass when treatment is initiated 1.5 weeks after ovariectomy in
mice
Claes Ohlsson, Lina Lawenius, Annica Andersson, Karin L. Gustafsson, Jianyao Wu, Marie Lagerquist, Sofia Moverare-Skrtic, Ulrika Islander, Klara Sjögren
American Journal of Physiology-Endocrinology and Metabolism - 2021 -
Acute fat loss does not affect bone
mass
Marie K Lagerquist, Karin L. Gustafsson, Petra Henning, Helen H. Farman, Jianyao Wu, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Louise Grahnemo
Scientific Reports - 2021 -
Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone
loss
Lina Lawenius, Julia M. Scheffler, Karin L. Gustafsson, Petra Henning, Karin H. Nilsson, Hannah Colldén, Ulrika Islander, H. Plovier, P. D. Cani, W. M. de Vos, Claes Ohlsson, Klara Sjögren
American Journal of Physiology-Endocrinology and Metabolism - 2020 -
Phosphorylation site S122 in estrogen receptor α has a tissue-dependent role in female
mice
Claes Ohlsson, Karin L. Gustafsson, Helen H. Farman, Petra Henning, Vikte Lionikaite, Sofia Movérare-Skrtic, Klara Sjögren, Anna E Törnqvist, Annica Andersson, Ulrika Islander, Angelina I Bernardi, Matti Poutanen, Pierre Chambon, Marie K Lagerquist
FASEB Journal - 2020 -
The effects of estradiol are modulated in a tissue-specific manner in mice with inducible inactivation of ERα after sexual
maturation.
Claes Ohlsson, Helen H. Farman, Karin L. Gustafsson, Jianyao Wu, Petra Henning, Sara H Windahl, Klara Sjögren, Jan-Åke Gustafsson, Sofia Movérare-Skrtic, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020 -
Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre
trial
Per-Anders Jansson, D. Curiac, I. L. Ahren, F. Hansson, T. M. Niskanen, Klara Sjögren, Claes Ohlsson
Lancet Rheumatology - 2019 -
The gut microbiota is a major regulator of androgen metabolism in intestinal
contents.
Hannah Colldén, Andreas Landin, Ville Wallenius, Erik Elebring, Lars Fändriks, Maria E. Nilsson, Henrik Ryberg, Matti Poutanen, Klara Sjögren, Liesbeth Vandenput, Claes Ohlsson
American journal of physiology. Endocrinology and metabolism - 2019 -
The androgen receptor is required for maintenance of bone mass in adult male
mice.
Jianyao Wu, Petra Henning, Klara Sjögren, Antti Koskela, Juha Tuukkanen, Sofia Movérare-Skrtic, Claes Ohlsson
Molecular and cellular endocrinology - 2019 -
ER alpha expression in T lymphocytes is dispensable for estrogenic effects in
bone
Karin L. Gustafsson, Karin H. Nilsson, Helen H. Farman, Vikte Lionikaite, Petra Henning, Jianyao Wu, Sara H Windahl, Ulrika Islander, Sofia Moverare-Skrtic, Klara Sjögren, Hans Carlsten, Claes Ohlsson, Marie Lagerquist
Journal of Endocrinology - 2018 -
Increased bone mass in a mouse model with low fat
mass.
Louise Grahnemo, Karin L. Gustafsson, Klara Sjögren, Petra Henning, Vikte Lionikaite, Antti Koskela, Juha Tuukkanen, Claes Ohlsson, Ingrid Wernstedt Asterholm, Marie Lagerquist
American journal of physiology. Endocrinology and metabolism - 2018 -
Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult
mice.
Claes Ohlsson, Petra Henning, Karin H. Nilsson, Jianyao Wu, Karin L. Gustafsson, Klara Sjögren, Anna E Törnqvist, Antti Koskela, Fu-Ping Zhang, Marie Lagerquist, Matti Poutanen, Juha Tuukkanen, Ulf H Lerner, Sofia Movérare-Skrtic
The Journal of endocrinology - 2018 -
Osteomicrobiology: A New Cross-Disciplinary Research
Field.
Claes Ohlsson, Klara Sjögren
Calcified tissue international - 2018 -
Body weight homeostat that regulates fat mass independently of leptin in rats and
mice.
John-Olov Jansson, Vilborg Palsdottir, Daniel Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E I Johansson, Roger D Cone, Daniel J Drucker, Jianyao Wu, Biljana Aleksic, Anna E Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H Windahl, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2018 -
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male
mice.
Claes Ohlsson, Ann Hammarstedt, Liesbeth Vandenput, Niina Saarinen, Henrik Ryberg, Sara H Windahl, Helen H. Farman, John-Olov Jansson, Sofia Movérare-Skrtic, Ulf Smith, Fu-Ping Zhang, Matti Poutanen, Shahram Hedjazifar, Klara Sjögren
American journal of physiology. Endocrinology and metabolism - 2017 -
Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2
signaling
Claes Ohlsson, G. Nigro, I. G. Boneca, Fredrik Bäckhed, P. Sansonetti, Klara Sjögren
Cellular Immunology - 2017 -
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related
traits
A. Teumer, Q. Qi, Maria Nethander, H. Aschard, S. Bandinelli, M. Beekman, S. I. Berndt, M. Bidlingmaier, L. Broer, A. Cappola, G. P. Ceda, S. Chanock, M. H. Chen, T. C. Chen, Y. D. I. Chen, J. Chung, F. Del Greco Miglianico, Joel Eriksson, L. Ferrucci, N. Friedrich, C. Gnewuch, M. O. Goodarzi, N. Grarup, T. Guo, E. Hammer, R. B. Hayes, A. A. Hicks, A. Hofman, J. J. Houwing-Duistermaat, F. Hu, D. J. Hunter, L. L. Husemoen, A. Isaacs, K. B. Jacobs, J. A. M. J. L. Janssen, John-Olov Jansson, N. Jehmlich, S. Johnson, A. Juul, M. Karlsson, T. O. Kilpelainen, P. Kovacs, P. Kraft, C. Li, A. Linneberg, Y. Liu, R. J. F. Loos, Mattias Lorentzon, Y. Lu, M. Maggio, R. Magi, J. Meigs, Dan Mellström, M. Nauck, A. B. Newman, M. N. Pollak, P. P. Pramstaller, I. Prokopenko, B. M. Psaty, M. Reincke, E. B. Rimm, J. I. Rotter, A. Saint Pierre, C. Schurmann, S. Seshadri, Klara Sjögren, P. E. Slagboom, H. D. Strickler, M. Stumvoll, Y. Suh, Q. Sun, C. Zhang, Johan Svensson, T. Tanaka, A. Tare, A. Tönjes, H. W. Uh, C. M. Van Duijn, D. van Heemst, Liesbeth Vandenput, R. S. Vasan, U. Völker, Sara M. Willems, Claes Ohlsson, H. Wallaschofski, R. C. Kaplan
Aging Cell - 2016 -
Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female
mice
Johan Svensson, Sara H Windahl, L. Saxon, Klara Sjögren, A. Koskela, J. Tuukkanen, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016 -
SERMs have substance-specific effects on bone, and these effects are mediated via ER alpha AF-1 in female
mice
Anna E Börjesson, Helen H. Farman, Sofia Movérare-Skrtic, Cecilia Engdahl, M. C. Antal, A. Koskela, J. Tuukkanen, Hans Carlsten, A. Krust, P. Chambon, Klara Sjögren, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
American Journal of Physiology-Endocrinology and Metabolism - 2016 -
Enzalutamide Reduces the Bone Mass in the Axial but not the Appendicular Skeleton in Male
Mice.
Jianyao Wu, Sofia Movérare-Skrtic, Anna E Börjesson, Marie K Lagerquist, Klara Sjögren, Sara H Windahl, Antti Koskela, Louise Grahnemo, Ulrika Islander, Anna S K Wilhelmson, Åsa Tivesten, Juha Tuukkanen, Claes Ohlsson
Endocrinology - 2016 -
Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth
factor-I.
Johan Svensson, Klara Sjögren, Malin Levin, Jan Borén, Åsa Tivesten, Claes Ohlsson
Endocrine - 2016 -
The bone-sparing effects of estrogen and WNT16 are independent of each
other
Sofia Movérare-Skrtic, Jianyao Wu, Petra Henning, Karin L. Gustafsson, Klara Sjögren, Sara H Windahl, A. Koskela, J. Tuukkanen, Anna E Börjesson, Marie K Lagerquist, Ulf H Lerner, F.P. Zhang, J.Å. Gustafsson, Matti Poutanen, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2015 -
Effects of the gut microbiota on bone
mass.
Claes Ohlsson, Klara Sjögren
Trends in endocrinology and metabolism: TEM - 2015 -
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility
fractures.
Sofia Movérare-Skrtic, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E Börjesson, Klara Sjögren, Sara H Windahl, Helen H. Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars Sävendahl, Jian Q Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H Lerner, Francesca Gori, Claes Ohlsson
Nature Medicine - 2014 -
Probiotics protect mice from ovariectomy-induced cortical bone
loss.
Claes Ohlsson, Cecilia Engdahl, Frida Fåk, Annica Andersson, Sara H Windahl, Helen H. Farman, Sofia Movérare-Skrtic, Ulrika Islander, Klara Sjögren
PloS one - 2014 -
The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is
modified.
Sofia Movérare-Skrtic, Anna E Börjesson, Helen H. Farman, Klara Sjögren, Sara H Windahl, Marie K Lagerquist, Annica Andersson, Alexandra Stubelius, Hans Carlsten, Jan-Åke Gustafsson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
The role of activation functions 1 and 2 of estrogen receptor-alpha for the effects of estradiol and selective estrogen receptor modulators in male
mice
Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, A. Koskela, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Hans Carlsten, M. C. Antal, A. Krust, P. Chambon, J. Tuukkanen, Marie K Lagerquist, Sara H Windahl, Claes Ohlsson
Journal of Bone and Mineral Research - 2013 -
Estrogen receptor-alpha in osteocytes is important for trabecular bone formation in male
mice
Sara H Windahl, Anna E Börjesson, Helen H. Farman, Cecilia Engdahl, Sofia Movérare-Skrtic, Klara Sjögren, Marie Lagerquist, Jenny Kindblom, A. Koskela, J. Tuukkanen, P. D. Pajevic, J. Q. Feng, K. Dahlman-Wright, P. Antonson, J. A. Gustafsson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2013 -
Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue
specimens.
Leena Strauss, Pia Rantakari, Klara Sjögren, Anu Salminen, Eve Lauren, Jenny Kallio, Pauliina Damdimopoulou, Minna Boström, Peter J Boström, Pirjo Pakarinen, Fuping Zhang, Paula Kujala, Claes Ohlsson, Sari Mäkelä, Matti Poutanen
The FASEB Journal - 2013 -
Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not
2.
Sara H Windahl, L Saxon, Anna E Börjesson, Marie Lagerquist, B Frenkel, Petra Henning, Ulf H Lerner, Gl Galea, Lb Meakin, Cecilia Engdahl, Klara Sjögren, Mc Antal, A Krust, P Chambon, LE Lanyon, Js Price, Claes Ohlsson
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 2013 -
The role of IGF-1 for fracture risk in
men
Liesbeth Vandenput, Klara Sjögren, Johan Svensson, Claes Ohlsson
Frontiers in endocrinology - 2012 -
The gut microbiota regulates bone mass in
mice
Klara Sjögren, Cecilia Engdahl, Petra Henning, Ulf H Lerner, Valentina Tremaroli, Marie Lagerquist, Fredrik Bäckhed, Claes Ohlsson
Journal of Bone and Mineral Research - 2012 -
Liver-derived igf-I regulates mean life span in
mice
Johan Svensson, Klara Sjögren, Jenny Fäldt, Niklas Andersson, Olle Isaksson, John-Olov Jansson, Claes Ohlsson
PLoS ONE - 2011 -
Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in
bone.
Anna E Börjesson, Sara H Windahl, Marie Lagerquist, Cecilia Engdahl, B Frenkel, Sofia Movérare-Skrtic, Klara Sjögren, Jenny Kindblom, Alexandra Stubelius, Ulrika Islander, Mc Antal, A Krust, P Chambon, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated
mice.
Sara H Windahl, Niklas Andersson, Anna E Börjesson, Charlotte Swanson, Johan Svensson, Sofia Movérare-Skrtic, Klara Sjögren, Linus Ruijin Shao, Marie Lagerquist, Claes Ohlsson
PloS one - 2011 -
Stimulation of both estrogen and androgen receptors maintains skeletal muscle mass in gonadectomized male mice but mainly via different
pathways.
Johan Svensson, Sofia Movérare-Skrtic, Sara H Windahl, Charlotte Swanson, Klara Sjögren
Journal of molecular endocrinology - 2010 -
Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 and adult muscle
mass.
Johan Svensson, Klara Sjögren, Claes Ohlsson
Journal of applied physiology - 2010 -
The role of estrogen receptor-alpha in growth plate cartilage for longitudinal bone
growth.
Anna E Börjesson, Marie Lagerquist, C Liu, Linus Ruijin Shao, Sara H Windahl, Camilla Karlsson, Klara Sjögren, Sofia Movérare-Skrtic, Mc Antal, A Krust, Subburaman Mohan, P Chambon, Lars Sävendahl, Claes Ohlsson
Journal of bone and mineral research - 2010 -
The role of liver-derived insulin-like growth
factor-I.
Claes Ohlsson, Subburaman Mohan, Klara Sjögren, Åsa Tivesten, Jörgen Isgaard, Olle Isaksson, John-Olov Jansson, Johan Svensson
Endocrine reviews - 2009 -
Elevated Aromatase Expression in Osteoblasts Leads to Increased Bone Mass without Systemic Adverse
Effects.
Klara Sjögren, Marie Lagerquist, Sofia Movérare-Skrtic, Niklas Andersson, Sara H Windahl, Charlotte Swanson, Subburaman Mohan, M Poutanen, Claes Ohlsson
Journal of bone and mineral research - 2009 -
Liver-derived IGF1 enhances the androgenic response in
prostate.
Johan Svensson, Jon Kindblom, Linus Ruijin Shao, Sofia Movérare-Skrtic, Marie Lagerquist, Niklas Andersson, Klara Sjögren, Katrien Venken, Dirk Vanderschueren, John-Olov Jansson, Olle Isaksson, Claes Ohlsson
The Journal of endocrinology - 2008 -
Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II
expression.
Johan Svensson, Åsa Tivesten, Klara Sjögren, Olle Isaksson, Göran Bergström, Subburaman Mohan, Johan Mölne, Jörgen Isgaard, Claes Ohlsson
The Journal of endocrinology - 2007 -
Regulation of growth hormone signaling by selective estrogen receptor modulators occurs through suppression of protein tyrosine
phosphatases.
Kin-Chuen Leung, Jesena Brce, Nathan Doyle, Heather J Lee, Gary M Leong, Klara Sjögren, Ken K Y Ho
Endocrinology - 2007 -
Growth hormone regulation of metabolic gene expression in muscle: a microarray study in hypopituitary
men
Klara Sjögren, Kin-Chuen Leung, Warren Kaplan, Margaret Gardiner-Garden, James Gibney, Ken K. Y. Ho
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM - 2007 -
Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and
dyslipidemia.
Mohammad Bohlooly-Yeganeh, Bob Olsson, Carl E G Bruder, Daniel Lindén, Klara Sjögren, Mikael Bjursell, Emil Egecioglu, Lennart Svensson, Peter Brodin, John C Waterton, Olle Isaksson, Frank Sundler, Bo Ahrén, Claes Ohlsson, Jan Oscarsson, Jan Törnell
Diabetes - 2005 -
Liver-derived IGF-I regulates exploratory activity in old
mice.
Johan Svensson, Bo Söderpalm, Klara Sjögren, Jörgen Engel, Claes Ohlsson
American journal of physiology. Endocrinology and metabolism - 2005 -
Investigation of central versus peripheral effects of estradiol in ovariectomized
mice
Niklas Andersson, Ulrika Islander, Emil Egecioglu, Elin Löf, Charlotte Swanson, Sofia Movérare-Skrtic, Klara Sjögren, Marie Lindberg, Hans Carlsten, Claes Ohlsson
J Endocrinol - 2005 -
Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in
vitro.
Gary M Leong, Sofia Movérare-Skrtic, Jesena Brce, Nathan Doyle, Klara Sjögren, Karin Dahlman-Wright, Jan-Ake Gustafsson, Ken K Y Ho, Claes Ohlsson, Kin-Chuen Leung
Endocrinology - 2004 -
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by
SOCS-2.
K C Leung, N Doyle, M Ballesteros, Klara Sjögren, C K W Watts, T H Low, G M Leong, R J M Ross, K K Y Ho
Proceedings of the National Academy of Sciences of the United States of America - 2003 -
Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in
mice.
Åsa Tivesten, Entela Bollano, Irene Andersson, Sharyn M. Fitzgerald, Kenneth Caidahl, Klara Sjögren, Ole Skøtt, Jun-Li Liu, Reza Mobini, Olle Isaksson, John-Olov Jansson, Claes Ohlsson, Göran Bergström, Jörgen Isgaard
Endocrinology - 2002 -
A model for tissue-specific inducible insulin-like growth factor-I (IGF-I) inactivation to determine the physiological role of liver-derived
IGF-I.
Klara Sjögren, John-Olov Jansson, Olle Isaksson, Claes Ohlsson
Endocrine - 2002 -
A transgenic model to determine the physiological role of liver-derived insulin-like growth factor
I.
Klara Sjögren, John-Olov Jansson, Olle Isaksson, Claes Ohlsson
Minerva endocrinologica - 2002 -
Effects of liver-derived insulin-like growth factor I on bone metabolism in
mice.
Klara Sjögren, Matilda Sheng, Sofia Movérare, Jun-Li Liu, Kristina Wallenius, Jan Törnell, Olle Isaksson, John-Olov Jansson, Subburaman Mohan, Claes Ohlsson
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 2002 -
Effects of GH and liver-derived IGF-I on growth and
metabolism
Klara Sjögren
2001 -
Liver-derived IGF-I regulates GH secretion at the pituitary level in
mice.
Kristina Wallenius, Klara Sjögren, X D Peng, S Park, Ville Wallenius, J L Liu, M. Umaerus, H Wennbo, Olle Isaksson, L Frohman, R Kineman, Claes Ohlsson, John-Olov Jansson
Endocrinology - 2001 -
Liver-derived IGF-I is of importance for normal carbohydrate and lipid
metabolism.
Klara Sjögren, Kristina Wallenius, J L Liu, Mohammad Bohlooly-Yeganeh, G Pacini, L Svensson, Jan Törnell, Olle Isaksson, Bo Ahrén, John-Olov Jansson, Claes Ohlsson
Diabetes - 2001 -
Metabolic functions of liver-derived (endocrine) insulin-like growth factor
I.
Olle Isaksson, John-Olov Jansson, Klara Sjögren, Claes Ohlsson
Hormone research - 2001 -
The somatomedin hypothesis revisited in a transgenic
model.
Olle Isaksson, Claes Ohlsson, Klara Sjögren, Kristina Wallenius, John-Olov Jansson
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 2001 -
Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver
growth.
Stanko Skrtic, Kristina Wallenius, Klara Sjögren, Olle Isaksson, Claes Ohlsson, John-Olov Jansson
Hormone research - 2001 -
Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry
technique.
Klara Sjögren, N Hellberg, Mohammad Bohlooly-Yeganeh, L. Savendahl, M S Johansson, T Berglindh, Ingvar Bosaeus, Claes Ohlsson
The Journal of nutrition - 2001 -
Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/-
mice.
Klara Sjögren, Mohammad Bohlooly-Yeganeh, Bob Olsson, Karen T Coschigano, Jan Törnell, Subburaman Mohan, Olle Isaksson, G Baumann, John J Kopchick, Claes Ohlsson
Biochemical and biophysical research communications - 2000 -
The relative importance of endocrine versus autocrine/paracrine insulin-like growth factor-I in the regulation of body
growth.
Claes Ohlsson, Klara Sjögren, John-Olov Jansson, Olle Isaksson
Pediatric nephrology (Berlin, Germany) - 2000 -
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in
mice.
Klara Sjögren, J L Liu, K Blad, Stanko Skrtic, Olle Vidal, Ville Wallenius, D LeRoith, Jan Törnell, Olle Isaksson, John-Olov Jansson, Claes Ohlsson
Proceedings of the National Academy of Sciences of the United States of America - 1999 -
Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like
cells.
Olle Vidal, Klara Sjögren, B I Eriksson, O Ljunggren, Claes Ohlsson
Biochemical and biophysical research communications - 1998