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General about Type 2 Diabetes

Type 2 diabetes is a consequence of insulin resistance combined with insufficient insulin secretion and increased hepatic glucose production. Insulin resistance means that the target cells for insulin (in particular, skeletal muscle, liver and adipose cells) become less responsive and, as a consequence, require more insulin for a given metabolic response.

Insulin resistance is induced by many environmental factors such as obesity, smoking, certain drugs, a sedentary life-style etc. The ongoing diabetes epidemic is mainly a consequence of the increasing prevalence of obesity in most populations.

Susceptibility genes also play an important role for the development of Type 2 diabetes. These genes interact with the environment, making individuals more prone to developing Type 2 diabetes as a consequence of weight gain or other lifestyle changes. 

 

Photo Silvia Gogg                           

Type 2 Diabetes

The research at the Lundberg Laboratory for Diabetes Research focuses on the pathogenesis of Type 2 diabetes, in particular the role of the adipose tissue and genes involved. Collaboration with the pharmaceutical industry allows the development of new therapeutic principles.

Forskare Shahram Hedjazifar
Page Manager: Gunilla Lindell|Last update: 3/4/2014
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