Started in 1968, the Prospective Population Study of Women in Gothenburg (PPSW) is historically one of the original epidemiological studies devoted to women’s health issues. PPSW is a multi-disciplinary study on a representative sample of women born 1908, 1914, 1918, 1922 and 1930. The cohort was examined on up to six occasions, most recently in 2006. Women provided information by medical examinations; face to face interviews covering history of physical and mental disease, social and psychological circumstances, and lifestyle; blood samples were collected at baseline for immediate and future analyses as well as at each subsequent visit. Therefore, some women have provided up to six blood samples. The serum was stored since 1968-69 and constitutes one of the oldest biobanks to date. Recent work provided evidence of the validity of biomarkers measured in this 40 year old frozen serum, with total cholesterol, triglycerides, insulin and vitamin D among them.
Picking serum samples for laboratory analyses from the 40 year old PPSW biobank.
Some topics of most recent interest include obesity, dementia, menopause, estrogen therapy, and sleep disturbances. Additionally, birth weights have now been retrieved from archives in order to gain a better understanding of these topics from a life course perspective. The investigators are currently completing a 37 year follow-up of survivors among the original 1462 participants.
The proportion of old people increases and the elderly are getting older. Today's elderly are healthier and more active than previous generations of older people. Few studies have systematically examined how aging and its conditions change between generations and the factors that contribute to these differences. Among these there is the H70 study which started in 1971 and is a unique population-based study of normative aging in 70 year old populations, focused on both medical and cognitive measures. Diet was measured by means of diet history and, in a sub-sample, body composition data has been collected, based on either the DXA or the BIS methods. Considerable knowledge of the normal aging development derived from the geriatric and gerontological population surveys H70 in Gothenburg. So far there have been five different 70-year old birth cohorts studied, and a number of secular trends in mental and physical health have been described across birth cohorts. In addition some cohorts have been followed longitudinally over 3 decades. Overall, over 600 articles and 60 dissertations have been published, based on H70 data. The H70 study is coordinated by several research groups, primarily Geriatrics, Primary Health Care, Psychiatry, and Epidemiology.
Lauren Lissner, 46 31-786 6847