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Clinical and experimental studies of tolerance mechanisms in the thymus


Immune dysregulation is a key feature of many diseases, e.g. autoimmunity and cancer, and even though the thymus is of vital importance for immune regulation, therapeutic tools to target thymic function are lacking. The overall aim is to to study mechanisms of central tolerance induction and test if thymic exosomes can be used to target the thymus and induce antigen specific central tolerance in the treatment of autoimmune diseases. Since knowledge gaps exist regarding basic mechanisms of thymic function, a broad translational approach is applied with five sub-projects in which clinical, epidemiological and experimental, in vitro and in vivo, studies are combined.

  • Clinical, epidemiological and immunological studies of early thymectomy to determine the role of the postnatal human thymus.
  • Characterization of human post-AIRE medullary thymic epithelial cells and Hassall´s corpuscles and their role in the formation of regulatory T-cells.
  • Studies of central tolerance induction against citrullinated peptides in In vitro and in vivo studies of thymic exosomes to test if they influence thymocyte selection, maturation and lineage decision and can be used for induction of central tolerance.
  • Clinical and experimental studies of thymic function and immunological characteristics in trisomy 21 and 22q11 deletion syndromes.

In the projects, we are utilizing a combination of a unique access to human thymus, experimental front-line methodology, epidemiological studies, animal models and a well-defined patient material to address a central scientific and clinical problem.

OE Portrait

Kontaktinformation

Olov Ekwall
Professor

Box 480 , 405 30 Göteborg

Besöksadress:
Guldhedsgatan 10 A, plan 1

Telefon:
046 31 343 80 85

Fax:
046 31 82 39 25

Sidansvarig: kommunikation@medicine.gu.se|Sidan uppdaterades: 2017-05-31
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