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The role of Staphylococcus aureus components during infection.

The bacterium Staphylococcus aureus gives rise to a wide range of infections varying from mild skin infections to serious and invasive life-threatening diseases such as septic arthritis and sepsis. S. aureus expresses many potential virulence factors, as cell-wall attached surface proteins and secreted proteins.

The main interest of my research has been the surface proteins of S. aureus — which they are, how they look and function, and if they contribute to pathogenesis in models of infection. Previously we have shown that the surface proteins clumping factor A, protein A, plasmin sensitive protein and fibronectin-binding protein A and B are virulence factors for septic arthritis and/or sepsis. Several of these proteins were as well increasing the bacterial survival/proliferation in a skin abscess model. We have also investigated how S. aureus virulence factors are expressed in different organs during infection. Recently I have included secreted factors like enterotoxins in the virulence studies.

I am also studying the potential of surface proteins as vaccine components. I have so far found one protein that protects against experimental S. aureus arthritis and sepsis.

Finally, we study the variation of gene sequences of surface proteins in a database of several thousand S. aureus genomes.
 

Kontaktinformation

Elisabet Josefsson

Box 480, 405 30 Göteborg

Besöksadress:
Guldhedsgatan 10A, plan 1

Telefon:
031-342 4228

Sidansvarig: kommunikation@medicine.gu.se|Sidan uppdaterades: 2015-06-11
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