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Utvalda publikationer


Andersson A, Bernardi A, Nurkkala-Karlsson M, Stubelius A, Ohlsson C, Carlsten H, Islander U.
Suppression of experimental arthritis and associated bone loss by a tissue-selective estrogen complex. Endocrinology. 2016 Jan 8:en20151820.
The paper shows that a tissue selective estrogen complex, comprising of estradiol plus the selective estrogen receptor modulator bazedoxifene, suppresses experimental arthritis and prevents associated bone loss equally efficient as estradiol alone but with minimal negative effects on reproductive organs.

Andersson A, Grahnemo L, Engdahl C, Stubelius A, Lagerquist MK, Carlsten H, Islander U.
IL-17-producing γδTCR+ cells are regulated by estrogen during development of experimental arthritis.
Clin Immunol. 2015 Sep 27. pii: S1521-6616(15)30047-4. doi:10.1016/j.clim.2015.09.014.
This study provide a broad characterization of the effects of the female sex hormone estradiol on IL-17-producing γδT cells in a variety of experimental models of arthritis in mice. Interestingly, estradiol selectively regulates the localization of IL-17-producing γδT cells, but not other γδT cells, during development of experimental arthritis.

Grahnemo L, Andersson A, Nurkkala-Karlsson M, Stubelius A, Svensson M.N.D, Ohlsson C, Carlsten H, Islander U.
Trabecular bone loss in collagen antibody-induced arthritis.
Arthritis Res Ther. 2015 Jul 25;17:189. doi: 10.1186/s13075-015-0703-5.
The study shows that collagen antibody-induced arthritis, a short reproducible arthritis model that is compatible with C57BL/6 mice, is associated with increased number of osteoclasts and trabecular bone loss.

Andersson A, Stubelius A, Nurkkala Karlsson M, Engdahl C, Erlandsson MC, Grahnemo L, Lagerquist MK, Islander U.
Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis.
Arthritis Research & Therapy 2015, 17:32, DOI: 10.1186/s13075-015-0548-y
This is the first study in which the effects of estradiol on Th17 cells have been characterized in experimental autoimmune arthritis. We report that estradiol treatment results in an increase of Th17 cells in lymph nodes during the early phase of arthritis development, but leads to a decrease of Th17 cells in joints during established arthritis. Our data suggest that this may be caused by interference with the CCR6-CCL20 pathway, which is important for Th17-cell migration.

Kontaktinformation

Ulrika Islander

Sidansvarig: kommunikation@medicine.gu.se|Sidan uppdaterades: 2017-05-31
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