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Fredrik Bäckhed

Professor

Fredrik Bäckhed
Professor
fredrik.backhed@gu.se

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Wallenberglab , Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Fredrik Bäckhed

Fredrik Bäckhed, an expert in cellular microbiology and mouse physiology, combines clinical oriented research with gnotobiotic mouse models to address the role of the normal gut microbiota in metabolic diseases.

Professor Bäckhed has received several prestigious awards.

Rewards and distinctions

  • Minkowski prize (2018)
  • Appointed Torsten Söderberg Professor in Medicine (2017)
  • Elected to The Royal Swedish Academy of
  • Engineering Sciences (2015)
  • Göran Gustafsson Award in Medicine (2014)
  • ERC consolidator (2013)
  • The “Prince Daniel´s Grant to young promising researchers”(2013)
  • The DuPont Young Professor Award (2013)
  • The DPLU/LUDC Nordic Prize for an Outstanding
  • Young Diabetes Investigator (2010)
  • Dr Eric K Fernström Foundation’s Prize to Young
  • Swedish Scientists (2010)
  • Ingvar Carlsson Award (2006)
  • Chorafas Prize (2003)

 

He has been elected to the Young Academy of Sweden hosted by the Royal Academy of Sciences (2011) Royal Academy of Engineering (2016) and Royal Academy of Sciences (2017).

For a profile about Professor Bäckhed and his group, please read the article from Research Media (opens in a new window): 

Gut Instincts and Unravelling the human gut

Main research 

The human intestinal tract is inhabited by 10-100 trillion microbes consisting of thousands of different species, collectively called the microbiota. The microbial community has an immense capacity to affect host biology and is fundamental to many processes, including the development of our immune system, processing of otherwise indigestible dietary polysaccharides, and vitamin and hormone production. The gut microbiome (collection of all microbial genes) encodes perhaps 1000-fold more genes than the human genome and provides us with numerous complementary functions and activities.

The overall aim of our research is to clarify the role of bacteria associated with the human body in the development of metabolic diseases, with particular emphasis on diabetes, steatosis, and atherosclerosis as well as delineating whether altered gut microbiota contributes to the beneficial effects of bariatric surgery. We use a translational approach that involves both human cohorts − to identify differences in microbial communities associated with the body in disease states − and germ-free mice − to investigate the underlying molecular mechanisms promoted by specific bacteria.

Key Publications

Koh A, Molinaro A, Ståhlman M, Khan M T, Schmidt C, Mannerås-Holm L, Wu H, Carreras A, Jeong H, Olofsson L E, Bergh P-O, Gerdes V, Hartstra A, de Brauw M, Perkins R, Nieuwdorp M, Bergström G, Bäckhed F.
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Cell Metabolism. 175(4):947-61 (2018)

Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernàndez-Real JM, Bäckhed F
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Nat Med. 2017 Jul;23(7):850-858. doi: 10.1038/nm.4345. Epub 2017 May 22

Karlsson, F., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., Bäckhed, F.
Gut metagenome in European women with normal, impaired and diabetic glucose control.
Nature. 498:99-103 (2013).

Group members

Team leaders

  • Louise Mannerås Holm, PhD
  • Louise Olofsson, PhD
  • Robert Caesar, PhD
  • Thomas Greiner, PhD
  • Valentina Tremaroli, PhD

Postdoctoral Fellow

  • Alba Carreras, PhD
  • Estelle Grasset, PhD
  • Tanweer Khan, PhD
  • Ara Koh, PhD
  • Petia Kovatcheva, PhD (back 2019)
  • Kim Krautkramer, MD PhD
  • Kassem Makki, PhD
  • Antonio Molinaro, MD PhD
  • Marc Schöler, MD
  • Tony Wu, PhD

PhD Student

  • Christina Heiss
  • Lisa Olsson
  • Kristien Fluitmann

Research Associate

  • Carina Arvidsson
  • Ulrica Enqvist
  • Louise Hellden
  • Anna Hallén
  • Robert Jakubowicz
  • Manuela Krämer
  • Oskar Persson

Bioinformatician

  • Harald Brolin
  • Meenakshi Pradhan

Metabolomics/Lipidomics

  • Marcus Ståhlman, PhD
  • Per-Olof Bergh

Laboratory Manager

  • Annika Lundqvist, PhD

Administrator

  • Christel Jansson
  • Olivia Jungstrand

 

Latest publications

Shining light on microbial signaling to distant organs
Fredrik Bäckhed
Proceedings of the National Academy of Sciences of the United States of America, Journal article 2019
Journal article

Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics
J. Sandberg, Petia Kovatcheva-Datchary, I. Bjorck, Fredrik Bäckhed, A. Nilsson
European Journal of Nutrition, Journal article 2019
Journal article

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS.
Angela Molinaro, Barbara Becattini, Arianna Mazzoli, Augusto Bleve, Lucia Radici et al.
Cell Metabolism, Journal article 2019
Journal article

Intestinal Microbiota in Cardiovascular Health and Disease
W. H. W. Tang, Fredrik Bäckhed, U. Landmesser, S. L. Hazen
Journal of the American College of Cardiology, Journal article 2019
Journal article

Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice
A. Poupeau, C. Garde, K. Sulek, K. Citirikkaya, J. T. Treebak et al.
Faseb Journal, Journal article 2019
Journal article

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
K. Kasahara, K. A. Krautkramer, E. Org, K. A. Romano, R. L. Kerby et al.
Nature Microbiology, Journal article 2018
Journal article

Showing 61 - 70 of 158

2016

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
Felix Sommer, Marcus Ståhlman, O. Ilkayeva, J. M. Arnemo, J. Kindberg et al.
Cell Reports, Journal article 2016
Journal article

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism
K. V. Grunddal, C. F. Ratner, B. Svendsen, Felix Sommer, M. S. Engelstoft et al.
Endocrinology, Journal article 2016
Journal article

2015

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Fredrik Bäckhed, Josefine Roswall, Y. Q. Peng, Qing-Ping Feng, H. J. Jia et al.
Cell Host & Microbe, Journal article 2015
Journal article

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Saeed Shoaie, Pouyan Ghaffari Nouran, Petia Kovatcheva-Datchary, Adil Mardinoglu, Partho Sarathi Sen et al.
Cell Metabolism, Journal article 2015
Journal article

Showing 61 - 70 of 158

Page Manager: Karin Allander|Last update: 9/19/2019
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