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Läs mer om Martin Bergö och hans forskning här (på engelska).
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Podocyte Geranylgeranyl Transferase Type-I Is Essential for Maintenance of the Glomerular Filtration
Barrier
Roberto Boi, Lovisa Bergwall, Kerstin Ebefors, Martin Bergö, Jenny Nyström, Lisa Buvall
Journal of the American Society of Nephrology - 2023 -
SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor
immunity
H. Zhong, W. Lu, Y. Tang, Clotilde Wiel, Y. Wei, J. Cao, G. Riedlinger, T. Papagiannakopoulos, J. Y. Guo, Martin O. Bergö, Y. B. Kang, S. Ganesan, H. E. Sabaawy, S. R. Pine
Oncogene - 2023 -
Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes
arthritis
Eric Malmhäll-Bah, Karin Andersson, Malin Erlandsson, Murali K Akula, Mikael Brisslert, Clotilde Wiel, Ahmed E El Zowalaty, Volkan I. Sayin, Martin O. Bergö, Maria Bokarewa
Journal of Autoimmunity - 2022 -
Antioxidants promote intestinal tumor progression in
mice.
Zhiyuan V. Zou, Kristell Le Gal, Ahmed E El Zowalaty, Lara Pehlivanoglu, Viktor Garellick, Nadia Gul, Mohamed X Ibrahim, Per-Olof Bergh, Marcus Henricsson, Clotilde Wiel, Levent Akyürek, Martin Bergö, Volkan I. Sayin, Per Lindahl
Antioxidants - 2021 -
Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte
egress
X. Du, H. Zeng, S. Liu, C. Guy, Y. Dhungana, G. Neale, Martin O. Bergö, H. Chi
The Journal of experimental medicine - 2020 -
Lack of RAC1 in macrophages protects against
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O. Bergö, Levent Akyürek
PLoS One - 2020 -
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating
GADD45b.
Christin Karlsson, Murali K Akula, Anna Staffas, Jaroslaw Cisowski, Volkan I. Sayin, Mohamed X Ibrahim, Per Lindahl, Martin Bergö
Leukemia - 2020 -
Genomic profiling of the transcription factor Zfp148 and its impact on the p53
pathway
Zhiyuan V. Zou, Nadia Gul, Markus Lindberg, Abdulmalik Bokhari, Ella M. Eklund, Viktor Garellick, Angana A. H. Patel, Jozefina J. Dzanan, Ben Titmuss, Kristell Le Gal, Inger Johansson, Åsa Tivesten, Eva Forssell-Aronsson, Martin O. Bergö, Anna Staffas, Erik Larsson, Volkan I. Sayin, Per Lindahl
Scientific Reports - 2020 -
Association of Bariatric Surgery With Skin Cancer Incidence in Adults With Obesity: A Nonrandomized Controlled
Trial.
Magdalena Taube, Markku Peltonen, Kajsa Sjöholm, Åsa Anveden, Johanna C. Andersson-Assarsson, Peter Jacobson, Per-Arne Svensson, Martin O. Bergö, Carlsson Lena
JAMA dermatology - 2020 -
Protein prenylation restrains innate immunity by inhibiting Rac1 effector
interactions
Murali K Akula, Mohamed X Ibrahim, Emil G. Ivarsson, O. M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, X. F. Xu, Mikael Brisslert, C. Brakebusch, D. Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergö
Nature Communications - 2019 -
Response by Akyürek et al to Letter Regarding Article, "Targeting Filamin A Reduces Macrophage Activity and
Atherosclerosis".
Levent Akyürek, Martin O. Bergö, Sashidar Bandaru
Circulation - 2019 -
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin alpha 4 beta 7 and Development of Colitis in
Mice
R. Lopez-Posadas, P. Fastancz, L. D. Martinez-Sanchez, J. Panteleev-Ivlev, V. Thonn, T. Kisseleva, L. S. Becker, A. Schulz-Kuhnt, S. Zundler, S. Wirtz, R. Atreya, B. Carle, O. Friedrich, S. Schurmann, M. J. Waldner, C. Neufert, C. H. Brakebusch, Martin Bergö, M. F. Neurath, I. Atreya
Gastroenterology - 2019 -
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer
Metastasis
Clotilde Wiel, Kristell Le Gal, M. X. Ibrahim, C. A. Jahangir, M. Kashif, H. D. Yao, Dorian V. Ziegler, X. F. Xu, Tanushree Ghosh, Tanmoy Mondal, Chandrasekhar Kanduri, Per Lindahl, Volkan I. Sayin, Martin O. Bergö
Cell - 2019 -
Targeting filamin A reduces macrophage activity and
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand, Sravani Devarakonda, Joakim Karlsson, Jimmy Van den Eynden, Göran Bergström, Max Levin, Jan Borén, Martin O. Bergö, Levent Akyürek
Circulation - 2019 -
Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein
Prenylation
M. Balaz, A. S. Becker, L. Balazova, L. Straub, J. Muller, G. Gashi, C. I. Maushart, W. F. Sun, H. Dong, C. Moser, C. Horvath, V. Efthymiou, Y. Rachamin, S. Modica, C. Zellweger, S. Bacanovic, P. Stefanicka, L. Varga, B. Ukropcova, M. Profant, L. Opitz, E. Z. Amri, Murali K Akula, Martin Bergö, J. Ukropec, C. Falk, N. Zamboni, M. J. Betz, I. A. Burger, C. Wolfrum
Cell Metabolism - 2019 -
Role of the C-terminal basic amino acids and the lipid anchor of the G gamma(2) protein in membrane interactions and cell
localization
M. A. Noguera-Salva, F. Guardiola-Serrano, M. L. Martin, A. Marcilla-Etxenike, Martin Bergö, X. Busquets, P. V. Escriba
Biochimica Et Biophysica Acta-Biomembranes - 2017 -
Massive parallel sequencing questions the pathogenic role of missense variants in dilated
cardiomyopathy.
Martin Dalin, P. Engström, Emil G. Ivarsson, Per Unneberg, Sara Light, Maria Schaufelberger, Thomas Gilljam, Bert Andersson, Martin O. Bergö
International journal of cardiology - 2017 -
Rho-A prenylation and signaling link epithelial homeostasis to intestinal
inflammation
R. Lopez-Posadas, C. Becker, C. Gunther, S. Tenzer, K. Amann, U. Billmeier, R. Atreya, G. Fiorino, S. Vetrano, S. Danese, A. B. Ekici, S. Wirtz, V. Thonn, A. J. M. Watson, C. Brakebusch, Martin Bergö, M. F. Neurath, I. Atreya
Journal of Clinical Investigation - 2016 -
Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor
Function
J. R. Christiansen, N. D. Pendse, S. Kolandaivelu, Martin Bergö, S. G. Young, V. Ramamurthy
Journal of Neuroscience - 2016 -
Targeting Zfp148 activates p53 and reduces tumor initiation in the
gut
Anna Nilton, Volkan I. Sayin, Zhiyuan V. Zou, Sama I. Sayin, Cecilia Bondjers, Nadia Gul, Pia Ågren, Per Fogelstrand, Ola Nilsson, Martin O. Bergö, Per Lindahl
OncoTarget - 2016 -
Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and
BRAF
Jaroslaw Cisowski, Volkan I. Sayin, Meng Liu, C. Karlsson, Martin Bergö
Oncogene - 2016 -
Control of the innate immune response by the mevalonate
pathway
Murali K Akula, M. Shi, Z. Z. Jiang, C. E. Foster, D. Miao, A. S. Li, X. M. Zhang, R. M. Gavin, S. D. Forde, G. Germain, S. Carpenter, C. V. Rosadini, K. Gritsman, J. J. Chae, R. Hampton, N. Silverman, E. M. Gravallese, J. C. Kagan, K. A. Fitzgerald, D. L. Kastner, D. T. Golenbock, Martin Bergö, D. H. Wang
Nature Immunology - 2016 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015 -
Wild-type KRAS inhibits oncogenic KRAS-induced T-all in
mice.
Anna Staffas, Christin Karlsson, Marta Persson, Lars Palmqvist, Martin Bergö
Leukemia - 2015 -
Myocardial KRASG12D expression does not cause cardiomyopathy in
mice
Martin Dalin, Zhiyuan V. Zou, Margareta Scharin Täng, Roghaiyeh Safari, Christin Karlsson, Martin Bergö
Cardiovascular Research - 2014 -
Antioxidants accelerate lung cancer progression in
mice.
Volkan I. Sayin, Mohamed X Ibrahim, Erik Larsson, Jonas A Nilsson, Per Lindahl, Martin Bergö
Science translational medicine - 2014 -
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of
VEGF-A
Sashidar Bandaru, Xianghua Zhou, Pegah Rouhi, Yan Zhang, Martin Bergö, Cao Yihai, Levent Akyürek
Oncogenesis - 2014 -
Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating
p53
Volkan I. Sayin, Omar M. Khan, Lara Pehlivanoglu, Anna Staffas, Mohamed X Ibrahim, Annika Asplund, Pia Ågren, Anna Nilton, Göran Bergström, Martin Bergö, Jan Borén, Per Lindahl
Circulation Research - 2014 -
Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue
cancer
G. Yan, R. Zou, Z. Chen, B. Fan, Z. Wang, Y. Wang, X. Yin, D. Zhang, L. Tong, F. Yang, W. Jiang, W. Fu, Martin Bergö, Martin Dalin, J. Zheng, S. Chen, J. Zhou
Acta Biochimica et Biophysica Sinica - 2014 -
Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant
Treatment
Volkan I. Sayin, Anna Nilton, Mohamed X Ibrahim, Pia Ågren, Erik Larsson, Marleen MR Petit, Lillemor Mattsson Hultén, Marcus Ståhlman, Bengt R Johansson, Martin Bergö, Per Lindahl
Plos One - 2013 -
Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in
Mice
Omar M. Khan, Murali K Akula, Kristina Skålen, Christin Karlsson, Marcus Ståhlman, S. G. Young, Jan Borén, Martin Bergö
Circulation - 2013 -
Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of
Progeria
Mohamed X Ibrahim, Volkan I. Sayin, Murali K Akula, Meng Liu, L. G. Fong, S. G. Young, Martin Bergö
Science - 2013 -
Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer
Disease
S. W. Cheng, D. F. Cao, D. A. Hottman, L. L. Yuan, Martin Bergö, L. Li
Journal of Biological Chemistry - 2013 -
p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in
tumors.
Susanne Fransson, Anne Uv, Henry Eriksson, Mattias K Andersson, Yvonne Wettergren, Martin Bergö, Katarina Ejeskär
Oncogene - 2012 -
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in
mice
Rajesh K. Nallapalli, Mohamed X Ibrahim, Xianghua Zhou, Sashidar Bandaru, Sai Naresh Sunkara, Björn Redfors, David Pazooki, Yin Zhang, Jan Borén, Yihai Cao, Martin Bergö, Levent Akyürek
Molecular Cancer - 2012 -
Severe hepatocellular disease in mice lacking one or both CaaX
prenyltransferases.
Shao H Yang, Sandy Y Chang, Yiping Tu, Gregory W Lawson, Martin Bergö, Loren G Fong, Stephen G Young
Journal of lipid research - 2012 -
Filamin A mediates HGF/c-MET signaling in tumor cell
migration.
Xianghua Zhou, Asli Toylu, Rajesh K. Nallapalli, Gisela M A Nilsson, Nese Atabey, Carl-Henrik Heldin, Jan Borén, Martin Bergö, Levent Akyürek
International journal of cancer. Journal international du cancer - 2011 -
Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative
disease
Anna-Karin Sjögren, Karin Andersson, Omar M. Khan, Frida J Olofsson, Christin Karlsson, Martin Bergö
Leukemia - 2011 -
Genetic Analyses of the CAAX Protein Prenyltransferases in
Mice
Mohamed X Ibrahim, Omar M. Khan, Martin Bergö
The Enzymes - 2011 -
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in
mice.
Omar M. Khan, Mohamed X Ibrahim, Ing-Marie Jonsson, Christin Karlsson, Meng Liu, Anna-Karin Sjögren, Frida J Olofsson, Mikael Brisslert, Sofia E M Andersson, Claes Ohlsson, Lillemor Mattsson Hultén, Maria Bokarewa, Martin Bergö
The Journal of clinical investigation - 2011 -
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer
segments.
Jeffrey R Christiansen, Saravanan Kolandaivelu, Martin Bergö, Visvanathan Ramamurthy
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Genetic studies on the functional relevance of the protein prenyltransferases in skin
keratinocytes
Roger Lee, Sandy Y Chang, H. Trinh, Y. Tu, Andrew C White, Brandon S. J. Davies, Martin Bergö, L. G. Fong, W. E. Lowry, Stephen G. Young
Oxford Journals About the Journal Human Molecular Genetics - 2010 -
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung
cancer
Meng Liu, Anna-Karin Sjögren, Christin Karlsson, Mohamed X Ibrahim, Karin Andersson, Frida J Olofsson, Annika Wahlström, Martin Dalin, Huiming Yu, Zhenggang Chen, Shao H. Yang, Stephen G. Young, Martin Bergö
Proceedings of the National Academy of Sciences of the United States of America - 2010 -
Caution! Analyze transcripts from conditional knockout
alleles.
Shao H. Yang, Martin Bergö, Emily Farber, Xin Qiao, Loren G. Fong, Stephen G Young
Transgenic research - 2009 -
Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in
mice.
Briony Cutts, Anna-Karin Sjögren, Karin Andersson, Annika Wahlström, Christin Karlsson, Birgitta Swolin, Martin Bergö
Blood - 2009 -
Posttranslationell modifiering av RAS – en angreppspunkt för
cancerbehandling.
Martin Bergö
Onkologi i Sverige - 2008 -
Genetic analyses of the role of RCE1 in RAS membrane association and
transformation.
Martin Bergö, Annika Wahlström, Loren G. Fong, Stephen G Young
Methods in enzymology - 2008 -
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative
disease.
Annika Wahlström, Briony Cutts, Meng Liu, Annika Lindskog, Christin Karlsson, Anna-Karin Sjögren, Karin Andersson, Stephen G Young, Martin Bergö
Blood - 2008 -
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular
development
Xianghua Zhou, Fei Tian, Johan Sandzen, R. Cao, E. Flaberg, L. Szekely, Y. Cao, Claes Ohlsson, Martin Bergö, Jan Borén, Levent Akyürek
Proc Natl Acad Sci U S A - 2007 -
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung
cancer
Anna-Karin Sjögren, Karin Andersson, Meng Liu, Briony Cutts, Christina Karlsson, Annika Wahlström, Martin Dalin, C. Weinbaum, P. J. Casey, Andrej Tarkowski, Birgitta Swolin, S. G. Young, Martin Bergö
J Clin Invest - 2007 -
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative
disease
Annika Wahlström, Briony Cutts, Christin Karlsson, Karin Andersson, Meng Liu, Anna-Karin Sjögren, Birgitta Swolin, S. G. Young, Martin Bergö
Blood - 2007 -
Prelamin A and lamin A appear to be dispensable in the nuclear
lamina
L. G. Fong, J. K. Ng, J. Lammerding, T. A. Vickers, M. Meta, N. Cote, B. Gavino, X. Qiao, S. Y. Chang, S. R. Young, S. H. Yang, C. L. Stewart, R. T. Lee, C. F. Bennett, Martin Bergö, S. G. Young
J Clin Invest - 2006 -
Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein
T
F. Fueller, Martin Bergö, S. G. Young, K. Aktories, G. Schmidt
Infect Immun - 2006 -
Protein farnesyltransferase inhibitors and
progeria
M. Meta, S. H. Yang, Martin Bergö, L. G. Fong, S. G. Young
Trends Mol Med - 2006 -
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome
mutation
S. H. Yang, M. Meta, X. Qiao, D. Frost, J. Bauch, C. Coffinier, S. Majumdar, Martin Bergö, S. G. Young, L. G. Fong
J Clin Invest - 2006 -
Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and
function
Annika Svensson, P.J. Casey, S.G. Young, Martin Bergö
Methods Enzymol - 2006 -
K-Ras is required for paclitaxel-stimulated activation of
Rac1
Zhenggang Chen, Martin Bergö, S.G. Young, P.J. Casey
Submitted - 2005 -
Postprenylation CAAX processing is required for proper localization of Ras but not Rho
GTPases
D. Michaelson, W. Ali, V. K. Chiu, Martin Bergö, J. Silletti, L. Wright, S. G. Young, M. Philips
Mol Biol Cell - 2005 -
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine
carboxylmethyltransferase
C. Papaharalambus, W. Sajjad, A. Syed, C. Zhang, Martin Bergö, R. W. Alexander, M. Ahmad
J Biol Chem - 2005 -
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer
cells
A. M. Winter-Vann, R. A. Baron, W. Wong, J. Dela Cruz, J. D. York, D. M. Gooden, Martin Bergö, S. G. Young, E. J. Toone, P. J. Casey
Proc Natl Acad Sci U S A - 2005 -
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome
mutation
S. H. Yang, Martin Bergö, J. I. Toth, X. Qiao, Y. Hu, S. Sandoval, M. Meta, P. Bendale, M. H. Gelb, S. G. Young, L. G. Fong
Proc Natl Acad Sci U S A - 2005 -
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and
B-Raf
Martin Bergö, B. J. Gavino, C. Hong, A. P. Beigneux, M. McMahon, P. J. Casey, S. G. Young
J Clin Invest - 2004 -
On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal
cardiomyopathy
Martin Bergö, H. D. Lieu, B. J. Gavino, P. Ambroziak, J. C. Otto, P. J. Casey, Q. M. Walker, S. G. Young
J Biol Chem - 2004 -
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient
mice
L. G. Fong, J. K. Ng, M. Meta, N. Cote, S. H. Yang, C. L. Stewart, T. Sullivan, A. Burghardt, S. Majumdar, K. Reue, Martin Bergö, S. G. Young
Proc Natl Acad Sci U S A - 2004 -
Lamin B1 is required for mouse development and nuclear
integrity
L. Vergnes, M. Peterfy, Martin Bergö, S. G. Young, K. Reue
Proc Natl Acad Sci U S A - 2004