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Fredrik Bäckhed


Fredrik Bäckhed

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Wallenberglab , Göteborg

Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Fredrik Bäckhed

Fredrik Bäckhed, an expert in cellular microbiology and mouse physiology, combines clinical oriented research with gnotobiotic mouse models to address the role of the normal gut microbiota in metabolic diseases.

Professor Bäckhed has received several prestigious awards.

Rewards and distinctions

  • Minkowski prize (2018)
  • Appointed Torsten Söderberg Professor in Medicine (2017)
  • Elected to The Royal Swedish Academy of
  • Engineering Sciences (2015)
  • Göran Gustafsson Award in Medicine (2014)
  • ERC consolidator (2013)
  • The “Prince Daniel´s Grant to young promising researchers”(2013)
  • The DuPont Young Professor Award (2013)
  • The DPLU/LUDC Nordic Prize for an Outstanding
  • Young Diabetes Investigator (2010)
  • Dr Eric K Fernström Foundation’s Prize to Young
  • Swedish Scientists (2010)
  • Ingvar Carlsson Award (2006)
  • Chorafas Prize (2003)

He has been elected to the Young Academy of Sweden hosted by the Royal Academy of Sciences (2011) Royal Academy of Engineering (2016) and Royal Academy of Sciences (2017).

Highly cited researcher

Fredrik Bäckhed is one of the world´s most cited researchers in 2019, according to Web of Science, Clarivate Analytics.
Read more here (NB: in Swedish)

For a profile about Professor Bäckhed and his group, please read the article from Research Media (opens in a new window): 

Gut Instincts and Unravelling the human gut

Main research 

The human intestinal tract is inhabited by 10-100 trillion microbes consisting of thousands of different species, collectively called the microbiota. The microbial community has an immense capacity to affect host biology and is fundamental to many processes, including the development of our immune system, processing of otherwise indigestible dietary polysaccharides, and vitamin and hormone production. The gut microbiome (collection of all microbial genes) encodes perhaps 1000-fold more genes than the human genome and provides us with numerous complementary functions and activities.

The overall aim of our research is to clarify the role of bacteria associated with the human body in the development of metabolic diseases, with particular emphasis on diabetes, steatosis, and atherosclerosis as well as delineating whether altered gut microbiota contributes to the beneficial effects of bariatric surgery. We use a translational approach that involves both human cohorts − to identify differences in microbial communities associated with the body in disease states − and germ-free mice − to investigate the underlying molecular mechanisms promoted by specific bacteria.

Key Publications

Koh A, Molinaro A, Ståhlman M, Khan M T, Schmidt C, Mannerås-Holm L, Wu H, Carreras A, Jeong H, Olofsson L E, Bergh P-O, Gerdes V, Hartstra A, de Brauw M, Perkins R, Nieuwdorp M, Bergström G, Bäckhed F.
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Cell Metabolism. 175(4):947-61 (2018)

Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernàndez-Real JM, Bäckhed F
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Nat Med. 2017 Jul;23(7):850-858. doi: 10.1038/nm.4345. Epub 2017 May 22

Karlsson, F., Tremaroli, V., Nookaew, I., Bergström, G., Behre, C. J., Fagerberg, B., Nielsen, J., Bäckhed, F.
Gut metagenome in European women with normal, impaired and diabetic glucose control.
Nature. 498:99-103 (2013).

Group members

Team leaders

  • Louise Mannerås Holm, PhD
  • Louise Olofsson, PhD
  • Robert Caesar, PhD
  • Thomas Greiner, PhD
  • Valentina Tremaroli, PhD

Postdoctoral Fellow

  • Alba Carreras, PhD
  • Estelle Grasset, PhD
  • Tanweer Khan, PhD
  • Ara Koh, PhD
  • Petia Kovatcheva, PhD (back 2019)
  • Kim Krautkramer, MD PhD
  • Kassem Makki, PhD
  • Antonio Molinaro, MD PhD
  • Marc Schöler, MD
  • Tony Wu, PhD

PhD Student

  • Christina Heiss
  • Lisa Olsson
  • Kristien Fluitmann

Research Associate

  • Carina Arvidsson
  • Ulrica Enqvist
  • Louise Hellden
  • Anna Hallén
  • Robert Jakubowicz
  • Manuela Krämer
  • Oskar Persson


  • Harald Brolin
  • Meenakshi Pradhan


  • Marcus Ståhlman, PhD
  • Per-Olof Bergh

Laboratory Manager

  • Annika Lundqvist, PhD


  • Christel Jansson
  • Olivia Jungstrand


Latest publications

Distinct differences in gut microbial composition and functional potential from lean to morbidly obese subjects
A. S. Meijnikman, O. Aydin, A. Prodan, Valentina Tremaroli, H. Herrema et al.
Journal of Internal Medicine, Journal article 2020
Journal article

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
M. L. Lund, G. Sorrentino, K. L. Egerod, C. Kroone, B. Mortensen et al.
Diabetes, Journal article 2020
Journal article

Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in nonobese diabetic mice
Marie-Christine Simon, A. L. Reinbeck, C. Wessel, J. Heindirk, T. Jelenik et al.
Journal of Biological Chemistry, Journal article 2020
Journal article

Showing 151 - 160 of 168


Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor
Fredrik Bäckhed, P. A. Crawford, D. O'Donnell, J. I. Gordon
Proc Natl Acad Sci U S A, Journal article 2007
Journal article

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Fredrik Bäckhed, J. K. Manchester, C. F. Semenkovich, J. I. Gordon
Proc Natl Acad Sci U S A, Journal article 2007
Journal article

Role of the Lipopolysaccharide-CD14 Complex for the Activity of Hemolysin from Uropathogenic Escherichia coli
Lisa E. Månsson, Peter Kjäll, Shahaireen Pellett, Gabor Nagy, Rodney A. Welch et al.
Infect. Immun., Journal article 2007
Journal article


Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers
J. E. Ippolito, M. E. Merritt, Fredrik Bäckhed, K. L. Moulder, S. Mennerick et al.
Proc Natl Acad Sci U S A, Journal article 2006
Journal article

Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers
J. E. Ippolito, M. E. Merritt, Fredrik Bäckhed, K. L. Moulder, S. Mennerick et al.
Proc Natl Acad Sci U S A, Journal article 2006
Journal article


Host-bacterial mutualism in the human intestine
Fredrik Bäckhed, R. E. Ley, J. L. Sonnenburg, D. A. Peterson, J. I. Gordon
Science, Review article 2005
Review article

Obesity alters gut microbial ecology
R. E. Ley, Fredrik Bäckhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight et al.
Proc Natl Acad Sci U S A, Journal article 2005
Journal article


The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed, H. Ding, T. Wang, L. V. Hooper, G. Y. Koh et al.
Proc Natl Acad Sci U S A, Journal article 2004
Journal article


Nanoscale features influence epithelial cell morphology and cytokine production
A. S. Andersson, Fredrik Bäckhed, A. von Euler, A. Richter-Dahlfors, D. Sutherland et al.
Biomaterials, Journal article 2003
Journal article

Showing 151 - 160 of 168

Page Manager: Karin Allander|Last update: 9/19/2019

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