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Michael Fu

Professor/ chief physician

Michael Fu
Professor/ chief physician

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Kardiologisektionen , Göteborg

Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Michael Fu

MD, PhD, FESC, Senior Consultant Physician/Cardiologist 
Michael Fu is an expert in heart failure with research focus on epidemiology, clinical phenotype, prognosis and its risk factors, comorbidities, prevention and treatment in patients with heart failure in particular in the elderly and heart failure with preserved ejection faction, with more than 200 original publications.

Professor Michael Fu is currently a nucleus member of Working Group of Heart Failure, Swedish Society of Cardiology, previous nucleus member of Working Group of Heart Failure with Preserved Ejection Fraction, Heart Failure Association, European Society of Cardiology.

Main research

Chronic heart failure (HF), which is accompanied by high morbidity and mortality, increases with age. Landmark randomized clinical trials have mainly been conducted in young HF patients (<63 years old) with reduced ejection fraction (HFREF). However, most HF patients are older and nearly half of them have normal systolic function (HF with normal ejection fraction; HFNEF). There are clearly severe limitations in extrapolating the available evidence from younger HF patients to the elderly HF population.

The prevalence of HFNEF is increasing at an alarming rate of ~1% per year, which will transform HFNEF into the most prevalent HF phenotype over the next decade. In recently published heart failure guidelines (European Society of Cardiology, May 2012), there is still a lack of uniform diagnostic criteria for HFNEF. Moreover, in contrast to HFREF, no improvements in outcome have been realized over the past 20 years. No HFNEF clinical trials have demonstrated positive outcomes, which may be partly due to the enrollment of inappropriate study populations because of the absence of a validated diagnostic method.

Elderly patients represent a high-risk cohort with significantly increased mortality and hospitalizations. Most of the current data addressing mortality of elderly HFNEF patients are derived from registry databases and data about hospitalization of this group are limited. Considerable uncertainty exists regarding the prognostic contributions from factors that are characteristic of elderly patients, such as various comorbidities, cognitive dysfunction and impaired mental health, in addition to advanced age.

Our immediate clinical interest in elderly HF patients emerged from the confluence of the following research questions:

  • How can an early and correct diagnosis of HFNEF be achieved?
  • What is the incidence of comorbidity in elderly HF patients?
  • How does comorbidity affect quality of life and prognosis in elderly HF patients?
  • Can optimal care of comorbidities improve quality of life and prognosis in elderly HF patients?

Group members

  • Salim Barywani, MD, PhD, Cardiologist
  • Eric Thunström, MD, PhD, physician
  • Constantinos Ergatoudes, physician, PhD student
  • Silvana Kontogeorgos, physician, PhD student
  • Chen Xiaojing, MD, PhD; postdoctoral fellow
  • Annika Odenstedt, research nurse
  • Sven Eric Hagelind, research nurse


Key Publications

Li S, Barywani S, Fu M.
Prognostic significance of mitral regurgitation in long-term all-cause mortality in patients aged ≥ 80 years with acute coronary syndrome.
Int J Cardiol. 176(2):340-5. (2014)

Jhund PS, Fu M, Bayram E, Chen CH, Negrusz-Kawecka M, Rosenthal A, Desai AS, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, McMurray JJ, Packer M.
Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF.
Eur Heart J. 36(38):2576-84. (2015)

Barywani SB, Ergatoudes C, Schaufelberger M, Petzold M, Fu M.
Does the target dose of neurohormonal blockade matter for outcome in Systolic heart failure in octogenarians?
Int J Cardiol. 187:666-72. (2015)

Bjurman C, Petzold M, Venge P, Farbemo J, Fu M, Hammarsten O.
High-sensitive cardiac troponin, NT-proBNP, hFABP and copeptin levels in relation to glomerular filtration rates and a medical record of cardiovascular disease.
Clin Biochem. 48(4-5):302-7. (2015)

Li S, Barywani S, Fu M.

Prognostic power of lower pulse pressure on long-term all-cause mortality in octogenarians with acute coronary syndrome: a propensity-score-matched cohort study.
J Hypertens. 33(2):279-86. (2015)

Fu M, Zhou J, Thunström E, Almgren T, Grote L, Bollano E, Schaufelberger M, Johansson MC, Petzold M, Swedberg K, Andersson B.

Optimizing the Management of Heart Failure With Preserved Ejection Fraction in the Elderly by Targeting Comorbidities (OPTIMIZE-HFPEF).
J Card Fail. 22(7):539-44. (2016)

Li SJ, Sartipy U, Lund LH, Dahlström U, Adiels M, Petzold M, Fu M.
Prognostic Significance of Resting Heart Rate and Use of β-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry.
Circ Heart Fail. 8(5):871-9. (2015)

Ergatoudes C, Thunström E, Rosengren A, Björck L, Bengtsson Boström K, Falk K, Fu M.
Long-term secondary prevention of acute myocardial infarction (SEPAT) - guidelines adherence and outcome.
BMC Cardiovasc Disord. 16(1):226. (2016).

Sigurjonsdottir R, Barywani S, Albertsson P, Fu M.
Long-term major adverse cardiovascular events and quality of life after coronary angiography in elderly patients with acute coronary syndrome.
Int J Cardiol. 1;222:481-5. (2016)

Kontogeorgos S, Thunström E, Johansson MC, Fu M.
Heart failure with preserved ejection fraction has a better long-term prognosis than heart failure with reduced ejection fraction in old patients in a 5-year follow-up retrospective study.
Int J Cardiol. 232:86-92 (2017)

Latest publications

Activation of T Lymphocytes as a Novel Mechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling
Y. Du, X. Li, H. Yu, L. Yan, W. B. Lau et al.
Cardiovascular Drugs and Therapy, Journal article 2019
Journal article

Prognostic impact of right bundle branch block in hospitalized patients with idiopathic dilated cardiomyopathy: a single-center cohort study.
W Fang, Rong Luo, Y Tang, W Hua, Michael Fu et al.
The Journal of international medical research, Journal article 2018
Journal article

The incidence of atrial fibrillation and the added value of thumb ECG for detecting new cases.
Zacharias Mandalenakis, Sandra Tahrodi Lennartsson, Michael Fu, Georgios Lappas, Shijun Li et al.
Scandinavian cardiovascular journal : SCJ, Journal article 2018
Journal article

β2-adrenergic receptor autoantibodies alleviated myocardial damage induced by β1-adrenergic receptor autoantibodies in heart failure.
Ning Cao, Hao Chen, Yan Bai, Xiaochun Yang, Wenli Xu et al.
Cardiovascular research, Journal article 2018
Journal article

Showing 81 - 90 of 199


Hypertension in the elderly: Where are we?
Michael Fu
International journal of cardiology, Review article 2011
Review article

Acute myocarditis -A Trigger of Cardiac Autoimmunity? Expected Insights from
Roland Jahns, Nikolas Neubner, Valerie Biovin, Alida Caforio, Stephan Felix et al.
InTECH open, Chapter in book 2011
Chapter in book


Inflammation increases NT-proBNP and the NT-proBNP/BNP ratio.
Juliana Jensen, Li-Ping Ma, Michael Fu, David Svaninger, Per-Arne Lundberg et al.
Clinical research in cardiology : official journal of the German Cardiac Society, Journal article 2010
Journal article

Increased stromal-cell-derived factor 1 enhances the homing of bone marrow derived mesenchymal stem cells in dilated cardiomyopathy in rats.
Yan-Li Zhou, Hai-Feng Zhang, Xin-Li Li, Ruo-Min DI, Wen-Ming Yao et al.
Chinese medical journal, Journal article 2010
Journal article

Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure.
Barry M Massie, Christopher M O'Connor, Marco Metra, Piotr Ponikowski, John R Teerlink et al.
The New England journal of medicine, Journal article 2010
Journal article

Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction.
Yingying Xu, Tingting Tang, Yingjun Ding, Rui Yao, Jiangjiao Xie et al.
The American journal of the medical sciences, Journal article 2010
Journal article

Growth Factor PDGF-BB Stimulates Cultured Cardiomyocytes to Synthesize the Extracellular Matrix Component Hyaluronan.
Urban Hellman, Linus Malm, Li-Ping Ma, Göran Larsson, Stellan Mörner et al.
PloS one, Journal article 2010
Journal article

Showing 81 - 90 of 199

Page Manager: Karin Allander|Last update: 9/19/2019

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