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Martin Bergö

Professor

Martin Bergö
Professor
martin.bergo@gu.se
+46 31 786 6731
0733-122224

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: SAK Medicinareg 1G, vån 5 , 41390 Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Martin Bergö

Main research

Our goal is to define the biochemical and medical importance of the posttranslational processing of CAAX proteins—including K-RAS and prelamin A—and to define the suitability of the CAAX protein processing enzymes as therapeutic targets for the treatment of cancer and other diseases.

The CAAX proteins undergo three posttranslational processing steps: prenylation, endoproteolysis, and methylation. These processing steps are mediated by five different enzymes (FTase, GGTase-I, RCE1, ZMPSTE24, ICMT) and render the carboxyl terminus of CAAX proteins hydrophobic stimulating interactions with membranes and effector proteins.

Mutations in the RAS proteins deregulate cell growth and are involved in the pathogenesis of cancer, such as lung-, colon, and pancreatic cancer and myeloid leukemia. Mutations in prelamin A causes Hutchinson-Gilford progeria syndrome – a pediatric syndrome associated with misshaped cell nuclei and a host of aging-like disease phenotypes. One strategy to render the mutant K-RAS and prelamin A less harmful is to interfere with their ability to bind to membrane surfaces (e.g., plasma membrane and nuclear envelope). This could be accomplished by inhibiting the enzymes that modify the CAAX motif.

We use genetic strategies in mice to understand the importance of the CAAX protein processing enzymes for cellular transformation and the development of solid and hematopoietic tumors induced by mutations in RAS and RAF proteins and the neurofibromatosis 1 gene (NF1), and for the development of progeria induced by prelamin A accumulation. We also attempt to define the biochemical consequences of CAAX protein processing for protein–protein interactions, membrane association, and protein stability.

Research tools and resources

We use a range of molecular and cellular biology techniques in mouse and human cells and mouse models and genetic strategies to define mechanisms and treatment of human diseases using conditional and conventional knockout and transgenic mice.

Group members

  • Martin Bergö, PhD, Professor
  • Christin Karlsson, PhD
  • Jaroslaw Cisowski, PhD
  • Clotilde Wiel, PhD

Read more about Martin Bergö and Sahlgrenska Cancer Center here.

Key Publications

(IF = impact factor)

Cisowski J, Sayin VI, Liu M, Karlsson C, and Bergo MO. (2015) Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF. Oncogene (In press) IF8.6

Staffas A, Staffas A, Karlsson C, Persson M, Palmqvist P, and Bergo MO. (2015) Wild-type KRAS inhibits oncogenic KRAS-induced T-ALL in mice. Leukemia (In press) IF10

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, and Bergo MO. (2014) Antioxidants accelerate lung cancer progression in mice. Science Transl. Med. 6: 221ra15. IF14

Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, and Bergo MO. (2013) Targeting isoprenylcysteine methylation improves disease phenotypes in a mouse model of accelerated aging. Science 340: 1330–1333. IF31

Khan O, Krishna M, Akula MK, Skalen K, Karlsson C, Ståhlman M, Young SG, Borén J, and Bergo MO. (2013) Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation 127: 782–790. IF15

Latest publications

Targeting filamin A reduces macrophage activity and atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand et al.
Circulation, Journal article 2019
Journal article

Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin alpha 4 beta 7 and Development of Colitis in Mice
R. Lopez-Posadas, P. Fastancz, L. D. Martinez-Sanchez, J. Panteleev-Ivlev, V. Thonn et al.
Gastroenterology, Journal article 2019
Journal article

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Murali K Akula, Mohamed X Ibrahim, Emil G. Ivarsson, O. M. Khan, Israiel T. Kumar et al.
Nature Communications, Journal article 2019
Journal article

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
Clotilde Wiel, Kristell Le Gal, M. X. Ibrahim, C. A. Jahangir, M. Kashif et al.
Cell, Journal article 2019
Journal article

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
M. Balaz, A. S. Becker, L. Balazova, L. Straub, J. Muller et al.
Cell Metabolism, Journal article 2019
Journal article

Massive parallel sequencing questions the pathogenic role of missense variants in dilated cardiomyopathy.
Martin Dalin, P. Engström, Emil G. Ivarsson, Per Unneberg, Sara Light et al.
International journal of cardiology, Journal article 2017
Journal article

Role of the C-terminal basic amino acids and the lipid anchor of the G gamma(2) protein in membrane interactions and cell localization
M. A. Noguera-Salva, F. Guardiola-Serrano, M. L. Martin, A. Marcilla-Etxenike, Martin Bergö et al.
Biochimica Et Biophysica Acta-Biomembranes, Journal article 2017
Journal article

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut
Anna Nilton, Volkan I. Sayin, Zhiyuan V. Zou, Sama I. Sayin, Cecilia Bondjers et al.
OncoTarget, Journal article 2016
Journal article

Control of the innate immune response by the mevalonate pathway
Murali K Akula, M. Shi, Z. Z. Jiang, C. E. Foster, D. Miao et al.
Nature Immunology, Journal article 2016
Journal article

Showing 1 - 10 of 56

2019

Targeting filamin A reduces macrophage activity and atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand et al.
Circulation, Journal article 2019
Journal article

Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin alpha 4 beta 7 and Development of Colitis in Mice
R. Lopez-Posadas, P. Fastancz, L. D. Martinez-Sanchez, J. Panteleev-Ivlev, V. Thonn et al.
Gastroenterology, Journal article 2019
Journal article

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Murali K Akula, Mohamed X Ibrahim, Emil G. Ivarsson, O. M. Khan, Israiel T. Kumar et al.
Nature Communications, Journal article 2019
Journal article

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
Clotilde Wiel, Kristell Le Gal, M. X. Ibrahim, C. A. Jahangir, M. Kashif et al.
Cell, Journal article 2019
Journal article

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
M. Balaz, A. S. Becker, L. Balazova, L. Straub, J. Muller et al.
Cell Metabolism, Journal article 2019
Journal article

2017

Massive parallel sequencing questions the pathogenic role of missense variants in dilated cardiomyopathy.
Martin Dalin, P. Engström, Emil G. Ivarsson, Per Unneberg, Sara Light et al.
International journal of cardiology, Journal article 2017
Journal article

Role of the C-terminal basic amino acids and the lipid anchor of the G gamma(2) protein in membrane interactions and cell localization
M. A. Noguera-Salva, F. Guardiola-Serrano, M. L. Martin, A. Marcilla-Etxenike, Martin Bergö et al.
Biochimica Et Biophysica Acta-Biomembranes, Journal article 2017
Journal article

2016

Targeting Zfp148 activates p53 and reduces tumor initiation in the gut
Anna Nilton, Volkan I. Sayin, Zhiyuan V. Zou, Sama I. Sayin, Cecilia Bondjers et al.
OncoTarget, Journal article 2016
Journal article

Control of the innate immune response by the mevalonate pathway
Murali K Akula, M. Shi, Z. Z. Jiang, C. E. Foster, D. Miao et al.
Nature Immunology, Journal article 2016
Journal article

Showing 1 - 10 of 56

Page Manager: Karin Allander|Last update: 9/19/2019
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