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Karin Manhem

Professor/ chief physician

Karin Manhem
Professor/ chief physician
karin.manhem@gu.se

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Medicinkliniken , Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Karin Manhem

Main Research

Cardivascular prevention with focus on hypertension. Registry- and cohortstudies on hypertension and related diseases.

High blood pressure (hypertension), the most significant risk factor for death worldwide according to WHO is the main focus for our research. Despite cost-effective drugs, the majority of individuals with hypertension are still not well-treated.

At present we study hypertension and its complications via two large registers created within the framework of primary health care in Sweden. In the Swedish Primary Care Cardiovascular Database (SPCCD) (n = 74751, mean age 69 +/- 13 years, 56% women) individual clinical patient data from 48 medical centers in patients with high blood pressure (collected from 2001 to 2008 with follow-up to 2013) are linked to the Medical register, National Board of the patient - and the cause of death records and Statistics Sweden's population register. Another large register, QRegPV , (Primary Care in the region of Västra Götaland) has a similar structure with linkage to national registers.

Our scientific questions at present include how cardiovascular morbidity in men and women with hypertension is affected by the type of treatment and achieved blood pressure. In particular we focus on the effect of hypertension and its treatment on fractures, stroke, atrial fibrillation, diabetes and metabolic disturbances. Finally we study patients with severe hypertension (resistant hypertension).

Group Members

  • Kristina Bengtsson Boström, Associated professor, specialist in general practise Närhälsan Billingen vårdcentral och Närhälsan FoU primärvård FoU-centrum Skaraborg
  • Per Hjerpe, PhD, specialist in general practise, Närhälsan Norrmalm Vårdcentral och Närhälsan FoU primärvård FoU-centrum Skaraborg
  • Andersson Björn, Associated professor, specialist in internal medicine, chief physician Omr 6, Medklin, SU/Sahlgrenska
  • Clara Hjalmarsson, PhD, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/ VO Kardiologi
  • Anna-Clara Collén, PhD, specialist in internal medicine, chief physician Med Klin SU/Östra
  • Charlotta Ljungman, PhD,specialist in internal medicine and cardiology, chief physician, Kardiologen Sahlgrenska universitetssjukhuset
  • Lina Holmqvist, PhD, specialist in internal medicine, Sahlgrenska Universitetssjukhuset/Sahlgrenska, Medicinkliniken
  • Georgios Mourtzinis, PhD student, specialist in internal medicine and cardiology, chief physician, Sahlgrenska Universitetssjukhuset/Medicin- och akutverksamhet Mölndal
  • Tove Bokrantz, PhD student, resident in general practise, Carlanderska Sjukhuset

Key Publications

Ljungman C, Kahan T, Schiöler L, Wettermark B, Boström KB, Hasselström J, Hjerpe P, Manhem K.
Non-steroidal anti-inflammatory drugs and blood pressure control in patients treated for hypertension: results from the Swedish primary care cardiovascular database.
Blood Press. 13:1-9. doi: 10.1080/08037051.2017.1290503. [Epub ahead of print] (2017)

Qvarnström M, Kahan T, Kieler H, Brandt L, Hasselström J, Boström KB, Manhem K, Hjerpe P, Wettermark B.
Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD).
Medicine (Baltimore). 95(40):e4908. (2016)

Bokrantz T, Ljungman C, Kahan T, Boström KB, Hasselström J, Hjerpe P, Mellström D, Schiöler L, Manhem K.
Thiazide diuretics and the risk of osteoporotic fractures in hypertensive patients. Results from the Swedish Primary Care Cardiovascular Database.
J Hypertens. 35(1):188-197. (2017)

Holmqvist L, Boström KB, Kahan T, Schiöler L, Hasselström J, Hjerpe P, Wettermark B, Manhem K.
Prevalence of treatment-resistant hypertension and important associated factors-results from the Swedish Primary Care Cardiovascular Database.
J Am Soc Hypertens. 10(11):838-846. doi: 10.1016/j.jash.2016.08.008. (2016)

Thunström E, Manhem K, Yucel-Lindberg T, Rosengren A, Lindberg C, Peker Y.
Neuroendocrine and Inflammatory Responses to Losartan and Continuous Positive Airway Pressure in Patients with Hypertension and Obstructive Sleep Apnea. A Randomized Controlled Trial.
Ann Am Thorac Soc. 13(11):2002-2011. (2016)

Adamsson Eryd S, Gudbjörnsdottir S, Manhem K, Rosengren A, Svensson AM, Miftaraj M, Franzén S, Björck S.
Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort study.
BMJ. 4;354:i4070. doi: 10.1136/bmj.i4070. (2016) 

Thunström E, Manhem K, Rosengren A, Peker Y.
Blood Pressure Response to Losartan and Continuous Positive Airway Pressure in Hypertension and Obstructive Sleep Apnea.
Am J Respir Crit Care Med. 1;193(3):310-20. doi: 10.1164/rccm.201505-0998OC. (2016)

Collén AC, Johansson MC, Guron CW, Gustafsson H, Manhem K.
Cardiac structure and function is related to current blood pressure rather than to previous hypertensive pregnancy.
J Hum Hypertens. 29(11):702-4. doi: 10.1038/jhh.2015.68. (2015)

Jansson S, Fredén Lindqvist J, Manhem K, Nilsson O, Rosén T, Herlitz H.
Quiz page June 2015: a young woman with hypertension.
Am J Kidney Dis. 65(6):A17-9. doi: 10.1053/j.ajkd.2015.01.027. (2015)

Collén AC, Gustafsson H, Hellgren M, Schiöler L, Bexander L, Manhem K.
Cardiovascular response to stress and perceived stress is not altered 40 years after hypertensive pregnancies.
Hypertens Pregnancy. 34(1):116-24. doi: 10.3109/10641955.2014.988348. (2015)

Ljungman C, Kahan T, Schiöler L, Hjerpe P, Hasselström J, Wettermark B, Boström KB, Manhem K.
Gender differences in antihypertensive drug treatment: results from the Swedish Primary Care Cardiovascular Database (SPCCD).
J Am Soc Hypertens. 8(12):882-90. doi: 10.1016/j.jash.2014.08.015. (2014)

Ljungman C, Kahan T, Schiöler L, Hjerpe P, Wettermark B, Boström KB, Manhem K.
Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD).
J Hum Hypertens. 29(6):385-93. doi: 10.1038/jhh.2014.100. (2015)

Latest publications

Treatment of hypertension in old patients without previous cardiovascular disease.
Johan-Emil Bager, Per Hjerpe, Karin Manhem, Staffan Björck, Stefan Franzén et al.
Journal of hypertension, Journal article 2019
Journal article

Meta-analyses and blood pressure goals
Karin Manhem, Annika Rosengren, Samuel Adamsson Eryd
The Journal of Clinical Hypertension, Editorial letter 2018
Editorial letter

Cardiovascular outcome in treatment-resistant hypertension: results from the Swedish Primary Care Cardiovascular Database (SPCCD).
Lina Holmqvist, Kristina B Boström, Thomas Kahan, Linus Schiöler, Jan Hasselström et al.
Journal of hypertension, Journal article 2018
Journal article

Mortality trends and cause of death in patients with new-onset type 2 diabetes and controls: A 24-year follow-up prospective cohort study.
Tobias Andersson, Per Hjerpe, Axel C Carlsson, Aldina Pivodic, Per Wändell et al.
Diabetes research and clinical practice, Journal article 2018
Journal article

Showing 1 - 10 of 62

2020

2019

Treatment of hypertension in old patients without previous cardiovascular disease.
Johan-Emil Bager, Per Hjerpe, Karin Manhem, Staffan Björck, Stefan Franzén et al.
Journal of hypertension, Journal article 2019
Journal article

2018

Meta-analyses and blood pressure goals
Karin Manhem, Annika Rosengren, Samuel Adamsson Eryd
The Journal of Clinical Hypertension, Editorial letter 2018
Editorial letter

Cardiovascular outcome in treatment-resistant hypertension: results from the Swedish Primary Care Cardiovascular Database (SPCCD).
Lina Holmqvist, Kristina B Boström, Thomas Kahan, Linus Schiöler, Jan Hasselström et al.
Journal of hypertension, Journal article 2018
Journal article

Mortality trends and cause of death in patients with new-onset type 2 diabetes and controls: A 24-year follow-up prospective cohort study.
Tobias Andersson, Per Hjerpe, Axel C Carlsson, Aldina Pivodic, Per Wändell et al.
Diabetes research and clinical practice, Journal article 2018
Journal article

Showing 1 - 10 of 62

Page Manager: Karin Allander|Last update: 9/19/2019
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