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Hanns-Ulrich Marschall

Professor/ chief physician

Hanns-Ulrich Marschall
Professor/ chief physician
hanns-ulrich.marschall@gu.se

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Magtarmlab , Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Hanns-Ulrich Marschall

Hanns-Ulrich Marschall, MD, PhD, MSc, is since 2010 Professor of Clinical Hepatology at Gothenburg University. He was Professor of Medical Gastroentology and Hepatology at the Karolinska Institute in Stockholm 2007-2010. He is a leading expert in bile acid metabolism and his research involves animal and human studies with focus on the interaction between bile acids and the gut microbiota at the Wallenberg Laboratory. He is also actively involved in a large number of sponsored and investigator-initiated clinical trials focusing on the development of new treatment options for non-alcoholic fatty liver disease/steatohepatitis and cholestatic liver diseases such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and in particular, intrahepatic cholestasis of pregnancy (ICP).

Main research

The farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and feedback-regulates bile acid and lipid metabolism. Extensive research over the past decade has placed specific FXR activation at the center of promising novel treatment options for cholestatic liver disorders and metabolic diseases such as type 2 diabetes, atherosclerosis and, in particular, non-alcoholic steatohepatitis.

To date, FXR activation studies have been conducted in animal models of cholestatic and fatty liver diseases and only subsequently translated into models of human relevance, mainly ex vivo/in vitro human cell systems. However, this strategy might miss important mechanistic insights since bile acid species (i.e. potential FXR ligands) differ profoundly between humans and mice. Moreover, bile acids activate several other FXR-independent metabolic signaling pathways and some might even act as FXR antagonists. Furthermore, the gut microbiota regulates species-specific secondary bile acid metabolism. Thus, changes in FXR-activated feedback loops might be differently translated between humans and rodents and depend on specific gut microbiota.

We aim to improve the translation of animal model studies on FXR activation to human diseases by identifying specific differences in FXR-dependent regulatory pathways between mice and humans and by comparing global DNA binding sites of FXR in mouse and human liver genomes. Our ultimate goal is to develop new treatment options for human cholestatic and fatty liver diseases.

Group Members

  • Annika Wahlström, PhD, Researcher
  • Johan Waern, MD, PhD, Postdoctoral Fellow
  • Samer Al-Dury, MD, PhD student
  • Niclas Björnfot, Registered Study Nurse
  • Olivia Jungstrand, Administrator

Key publications

Krones E, Eller K, Pollheimer MJ, Racedo S, Kirsch AH, Frauscher B, Wahlström A, Ståhlman M, Trauner M, Grahammer F, Huber TB, Wagner K, Rosenkranz AR, Marschall HU, Fickert P.
NorUrsodeoxycholic acid ameliorates cholemic nephropathy in bile duct ligated mice.
J Hepatol doi: 10.1016/j.jhep.2017.02.019 (2017).

Wahlström A, Kovatcheva-Datchary P, Ståhlman M, Khan MT, Bäckhed F, Marschall HU.
Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota.
J Lipid Res. 58:412-419 (2017).

Fuchs CD, Paumgartner G, Wahlström A, Schwabl P, Reiberger T, Leditznig N, Stojakovic T, Rohr-Udilova N, Chiba P, Marschall HU, Trauner M.
Metabolic preconditioning protects BSEP/ABCB11(-/-) mice against cholestatic liver injury.
J Hepatol. 66:95-101 (2017).

Nevens F, Andreone P, Mazzella G, Strasser SI, Bowlus C, Invernizzi P, Drenth JP, Pockros PJ, Regula J, Beuers U, Trauner M, Jones DE, Floreani A, Hohenester S, Luketic V, Shiffman M, van Erpecum KJ, Vargas V, Vincent C, Hirschfield GM, Shah H, Hansen B, Lindor KD, Marschall HU, Kowdley KV, Hooshmand-Rad R, Marmon T, Sheeron S, Pencek R, MacConell L, Pruzanski M, Shapiro D; POISE Study Group.
A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.
N Engl J Med. 375:631-43 (2016).

Wahlström A, Sayin SI, Marschall HU, Bäckhed F.
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism.
Cell Metab. 24:41-50 (2016).

Kummen M, Holm K, Anmarkrud JA, Nygård S, Vesterhus M, Høivik ML, Trøseid M, Marschall HU, Schrumpf E, Moum B, Røsjø H, Aukrust P, Karlsen TH, Hov JR.
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls.
Gut. doi: 10.1136/gutjnl-2015-310500 (2016).

Baghdasaryan A, Fuchs CD, Österreicher CH, Lemberger UJ, Halilbasic E, Påhlman I, Graffner H, Krones E, Fickert P, Wahlström A, Ståhlman M, Paumgartner G, Marschall HU, Trauner M.
Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis.
J Hepatol. 64:674-81 (2016).

Graffner H, Gillberg PG, Rikner L, Marschall HU.
The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation.
Aliment Pharmacol Ther. 43:303-10 (2016).

Wikström Shemer EA, Stephansson O, Thuresson M, Thorsell M, Ludvigsson JF, Marschall HU.
Intrahepatic cholestasis of pregnancy and cancer, immune-mediated
and cardiovascular diseases: A population-based cohort study.

J Hepatol. 63:456-61 (2016).

Marschall HU, Wikström Shemer E, Ludvigsson JF, Stephansson O.
Intrahepatic cholestasis of pregnancy and associated hepatobiliary disease: a population-based cohort study.
Hepatology. 58:1385-91 (2013).

Latest publications

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis
E. Bellafante, S. McIlvride, V. Nikolova, H. M. Fan, L. B. Manna et al.
Scientific Reports, Journal article 2020
Journal article

Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia.
Vanessa Pataia, Saraid McIlvride, Georgia Papacleovoulou, Caroline Ovadia, Julie A K McDonald et al.
American journal of physiology. Gastrointestinal and liver physiology, Journal article 2020
Journal article

Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy.
Luiza Borges Manna, Georgia Papacleovoulou, Flavia Flaviani, Vanessa Pataia, Asaad Qadri et al.
Scientific reports, Journal article 2020
Journal article

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
James E D Thaventhiran, Hana Lango Allen, Oliver S Burren, William Rae, Daniel Greene et al.
Nature, Journal article 2020
Journal article

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Cheng Zhang, Elias Bjornson, Muhammad Arif, Abdellah Tebani, Alen Lovric et al.
Molecular systems biology, Journal article 2020
Journal article

Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis.
C R H Hedin, G Sado, N Ndegwa, E Lytvyak, A Mason et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Journal article 2020
Journal article

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis.
Katrin Panzitt, Emilian Jungwirth, Elisabeth Krones, Jae Man Lee, Marion Pollheimer et al.
Journal of hepatology, Journal article 2020
Journal article

Whole-genome sequencing of patients with rare diseases in a national health system.
Ernest Turro, William J Astle, Karyn Megy, Stefan Gräf, Daniel Greene et al.
Nature, Journal article 2020
Journal article

Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
C. Ovadia, A. Perdones-Montero, H. M. Fan, B. H. Mullish, J. A. K. McDonald et al.
Scientific Reports, Journal article 2020
Journal article

Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice
C. D. Fuchs, S. Krivanec, D. Steinacher, V. Mlitz, Annika Wahlström et al.
Liver International, Journal article 2020
Journal article

Showing 1 - 10 of 119

2020

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis
E. Bellafante, S. McIlvride, V. Nikolova, H. M. Fan, L. B. Manna et al.
Scientific Reports, Journal article 2020
Journal article

Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia.
Vanessa Pataia, Saraid McIlvride, Georgia Papacleovoulou, Caroline Ovadia, Julie A K McDonald et al.
American journal of physiology. Gastrointestinal and liver physiology, Journal article 2020
Journal article

Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy.
Luiza Borges Manna, Georgia Papacleovoulou, Flavia Flaviani, Vanessa Pataia, Asaad Qadri et al.
Scientific reports, Journal article 2020
Journal article

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
James E D Thaventhiran, Hana Lango Allen, Oliver S Burren, William Rae, Daniel Greene et al.
Nature, Journal article 2020
Journal article

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Cheng Zhang, Elias Bjornson, Muhammad Arif, Abdellah Tebani, Alen Lovric et al.
Molecular systems biology, Journal article 2020
Journal article

Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis.
C R H Hedin, G Sado, N Ndegwa, E Lytvyak, A Mason et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Journal article 2020
Journal article

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis.
Katrin Panzitt, Emilian Jungwirth, Elisabeth Krones, Jae Man Lee, Marion Pollheimer et al.
Journal of hepatology, Journal article 2020
Journal article

Whole-genome sequencing of patients with rare diseases in a national health system.
Ernest Turro, William J Astle, Karyn Megy, Stefan Gräf, Daniel Greene et al.
Nature, Journal article 2020
Journal article

Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
C. Ovadia, A. Perdones-Montero, H. M. Fan, B. H. Mullish, J. A. K. McDonald et al.
Scientific Reports, Journal article 2020
Journal article

Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice
C. D. Fuchs, S. Krivanec, D. Steinacher, V. Mlitz, Annika Wahlström et al.
Liver International, Journal article 2020
Journal article

Showing 1 - 10 of 119

Page Manager: Karin Allander|Last update: 9/19/2019
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