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Åsa Tivesten

Professor/ chief physician

Åsa Tivesten
Professor/ chief physician
asa.tivesten@medic.gu.se
+46 31-342 1000

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Blå stråket 5 b wallenberglab/su , 41345 Göteborg


Department of Molecular and Clinical Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 31823762
Visiting Address: Blå stråket 5 B Wallenberglab/SU , 413 45 Göteborg

About Åsa Tivesten

Dr Åsa Tivesten is professor at the Wallenberg Laboratory for Cardiovascular Research at the Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. She received her MD in 1994 and her PhD in 2003. She has a board certificate as physician in Internal Medicine (2003) and has worked as a senior consultant since 2013.

Dr Tivesten’s research focuses on the cardiovascular actions of sex hormones, particularly on atherosclerosis. In her research, she combines experimentation on animals with epidemiological methods.

Main research

Cardiovascular disease (CVD) is the leading cause of death in Sweden and globally. Atherosclerosis is the most important underlying mechanism for ischemic heart disease, the major form of CVD. A smaller, but clinically important, type of CVD is abdominal aortic aneurysms (AAAs).

An AAA is a pathological widening of the abdominal aorta, which in many cases remains asymptomatic but may result in a life-threatening sudden rupture of the aortic wall. Although certain risk factors are shared between atherosclerotic cardiovascular disease and AAAs, these clearly represent two distinct vascular diseases.

Since a few years back, all Swedish men, but not women, are offered an ultrasound screening for AAA at 65 years of age. There is a strong male preponderance in both atherosclerosis-based CVD and AAAs, but the actions of sex steroids in these diseases are poorly defined.

The overall aim of our research is to determine the role of androgens (“male” sex steroids, e.g. testosterone) in atherosclerotic CVD and AAAs. In our research, we combine epidemiology with studies in genetically manipulated mice to answer questions concerning the cardiovascular actions of sex steroids.

Group members

  • Inger Johansson, Staff Scientist
  • Yvonne Björk, PhD Student
  • Marta Lantero Rodriguez, PhD Student
  • Elin Svedlund, PhD Student
  • Annelie Carlsson, Research Associate
  • Catharina Olivius (MD, PhD)

Funding

  • Swedish Research Council
  • Swedish Heart-Lung Foundation
  • Novo Nordisk Foundation
  • ALF Göteborg

Key Publications

Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å.
Testosterone is an endogenous regulator of BAFF and splenic B cell number.
Nature Communications 2018 May 25;9(1):2067.

Wilhelmson AS, Lantero Rodriguez M, Svedlund Eriksson E, Johansson I, Fogelstrand P, Stubelius A, Lindgren S, Fagman JB, Hansson GK, Carlsten H, Karlsson MCI, Ekwall O, Tivesten Å.
Testosterone protects against atherosclerosis in male mice by targeting thymic epithelial cells.
Arteriosclerosis, Thrombosis, and Vascular Biology 2018 Jul;38(7):1519-1527.

Wilhelmson AS, Fagman JB, Johansson I, Zou ZV, Andersson AG, Svedlund Eriksson E, Johansson ME, Lindahl P, Fogelstrand P, Tivesten Å.
Increased Intimal Hyperplasia After Vascular Injury in Male Androgen Receptor-Deficient Mice.
Endocrinology. 157(10):3915-3923. Epub 2016 Aug 17. (2016)

Fagman JB, Wilhelmson AS, Motta BM, Pirazzi C, Alexanderson C, De Gendt K, Verhoeven G, Holmäng A, Anesten F, Jansson JO, Levin M, Borén J, Ohlsson C, Krettek A, Romeo S, Tivesten Å.
The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice.
FASEB J. 29(4):1540-50. (2015)

Tivesten Å, Nilsson M, Carlzon D, Vandenput L, Karlsson MK, Ljunggren Ö, Barrett-Connor E, Mellström D, Ohlsson C.
Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men.
J Am Coll Cardiol. 64(17):1801-10. (2014)

Ohlsson C, Barrett-Connor E, Bhasin S, Orwoll E, Labrie F, Karlsson MK, Ljunggren O, Vandenput L, Mellström D, Tivesten Å.
High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden.
J Am Coll of Cardiol. 58(16):1674-81. (2011)

Latest publications

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2019

2018

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2016

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Page Manager: Karin Allander|Last update: 9/19/2019
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