Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Huamei Forsman

Researcher

Huamei Forsman
Researcher
huamei.forsman@rheuma.gu.se

Postal Address: Box 480, 40530 Göteborg
Visiting Address: Guldhedsgatan 10A, plan 2 , 41346 Göteborg


Department of Rheumatology a Inflammation Research at Institute of Medicine (More Information)
Box 480
405 30 Göteborg
0313421000
Fax: +46 31823925
Visiting Address: Medicinaregatan 3, plan 5 , 413 90 Göteborg

About Huamei Forsman

Research

The overall goal with my research is to understand G-protein Coupled Receptors (GPCR) activation and signaling in health and disease. The receptor specific ligands identified in combination with the mechanistic insights obtained should help us design GPCR-based therapeutics to modulate inflammation in disease situations.

Phagocyte function and inflammatory process are highly regulated by a large group of seven transmembrane GPCRs. These include the ones recognize microbial patterns as well as ”danger signals”, formyl peptides (FPRs), free fatty acids (FFARs), and the ATP receptor (P2Y2R) as well as classic chemoattractant receptors such as platelet activating factor receptor (PAFR), complement fragment 5 receptor (C5aR) and interleukin 8 receptor (CXCR1/2). Many GPCRs in particular the FPRs have been suggested to be of major importance for the initiation and resolution of inflammation, despite this, the precise mechanism of GPCR regulation in inflammation is still not yet understood.

To approach GPCRs in health and disease, we focus on the following three specific projects:

1. GPCR ligand recognition in phagocytes. We have during the last 10 year period identified and characterized a number of different GPCR ligands (agonists, antagonists, and allosteric modulators) belonging to different chemical classes ranging from small compounds, pepducins to the proteolytic stable peptidomimetics. The screening work is still ongoing and the identified receptor specific ligands are subjected for further mechanistic study, structure-activity relationship study, and medicinal chemistry optimization for improved potency as well as bioactivity.

2. GPCR biased signaling and functional selectivity. Biased signaling is an emerging concept in the GPCR field. We focus on the biased signaling regulated by the actin cytoskeleton, G-protein, as well as beta arrestin downstream neutrophil GPCRs. The identified biased agonism and their downstream signaling pathway leading to a selective functional response in phagocytes will be studied.

3.GPCR-mediated phagocyte function in health and disease. These studies are performed on both blood and tissue phagocytes obtained from patients suffering from various inflammatory disorders and patients with primary immunodeficiency diseases with well-defined genetic defects. The GPCR- and phagocyte-based assay platform is applied to monitor cell signaling and functions.

Group members

Claes Dahlgren – Senior Professor
Martina Sundqvist – Postdoc
Lena Björkman – MD, Postdoc
Michael Gabl – PhD student
Jonas Mårtensson – MD, PhD student
Felix Klose – PhD student
André Holdfeldt – Project assistent
Simon Lind – PhD student
Linda Bergqvist – Lab manager

Latest publications

Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Neutrophil recruitment to inflamed joints can occur without cellular priming.
Lena Björkman, Karin Christenson, Lisa Davidsson, Jonas Mårtensson, Firoozeh Amirbeagi et al.
Journal of leukocyte biology, Journal article 2019
Journal article

Showing 1 - 10 of 75

2019

Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Neutrophil recruitment to inflamed joints can occur without cellular priming.
Lena Björkman, Karin Christenson, Lisa Davidsson, Jonas Mårtensson, Firoozeh Amirbeagi et al.
Journal of leukocyte biology, Journal article 2019
Journal article

2018

Showing 1 - 10 of 75

Page Manager: Karin Allander|Last update: 9/19/2019
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?