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Lill Mårtensson-Bopp

Professor

Lill Mårtensson-Bopp
Professor , Avd-/sektionschef, inst
lill.martensson@rheuma.gu.se

Postal Address: Box 480, 40530 Göteborg
Visiting Address: Guldhedsgatan 10 , 41346 Göteborg


Department of Rheumatology a Inflammation Research at Institute of Medicine (More Information)
Box 480
405 30 Göteborg
0313421000
Fax: +46 31823925
Visiting Address: Medicinaregatan 3, plan 5 , 413 90 Göteborg

About Lill Mårtensson-Bopp

Professor in Molecular medicine, Head of the Department of Rheumatology and Inflammation Research.

  • MSc Pharmacy, University of Uppsala, Sweden
  • PhD, University of Uppsala, Sweden
  • Postdoc, Basel Institute for Immunology, Basel, Switzerland
  • Assist Prof, Lund University, Sweden
  • PI, The Babraham Institute (Cambridge), UK

Research

B cells in health and disease
B cells are central to the immune system, for instance in their role as antibody producing cells. Antibodies are found on the surface of B cells (BCR) and in blood. Antibodies protect by binding to unique structures on pathogens, which leads to the formation of immune complexes that are disposed off by the body. Each B cell synthesises a unique antibody due to a process in which antibody gene segments are randomly recombined. However, this can also lead to the synthesis of antibodies that recognise self, autoantibodies, one of the hallmarks of autoimmune disease, where immune complexes appear involved in organ damage and destruction. By contrast, immunodeficiency is characterised by a lack of antibodies and is associated with persistent infections. There are also B-lineage cancers, eg acute lymphocytic leukaemia (ALL). These diseases are complex, including gender, genetic and environmental factors.

Our aim is to better understand the molecular and cellular mechanisms underlying the development of disease. We focus on the pre-BCR and BCR, and the importance of these receptors at the checkpoints indicated in the Figure below (red arrows), during B cell development and differentiation in health and disease. Our research translational; our observations in mouse models are translated to healthy individuals and patients, and vice versa.

In the bone marrow, pro-B cells develop into pre-B cells that express a pre-B cell receptor (pre-BCR) on the cell surface. As these cells leave the cell cycle, they develop into immature B (iB) cells that express a BCR, i.e. membrane bound antibody. iB cells leave the bone marrow and migrate via blood to peripheral lymphoid organs, e.g. spleen. Here, as transitional B (TrB) cells, they mature into naïve B cells. As such, they are ready to take part in immune responses provided their BCR bind cognate antigen. In the context of T cells and other immune cells, the B cells are activated and move into structures termed germinal centres. Here, the B cells undergo clonal expansion and the BCRs are diversified in order to increase their affinity for antigen. When the cells leave these structures, they differentiate into memory B cells (MBC) or antibody-secreting plasma cells. Our results suggest that dysfunctional checkpoints are involved in the development of autoimmune diseases and leukaemia.

Group Members

  • Aranburu, Alaitz
  • Camponeschi, Alessandro
    alessandro.camponeschi@rheuma.gu.se
  • Chen, Dongfeng
    dongfeng.chen@gu.se
  • Gerasimcik, Natalija
    natalija.gerasimcik@rheuma.gu.se
  • Bergqvist, Linda
  • Höök, Nina (Medical student)
  • Grimsholm, Ola

Latest publications

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
E. Sondergaard, A. Rauch, M. Michaut, N. Rapin, M. Rehn et al.
Cell Reports, Journal article 2019
Journal article

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Maugeri Marco, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi et al.
Nature Communications, Journal article 2019
Journal article

Showing 1 - 10 of 25

2019

ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
E. Sondergaard, A. Rauch, M. Michaut, N. Rapin, M. Rehn et al.
Cell Reports, Journal article 2019
Journal article

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Maugeri Marco, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi et al.
Nature Communications, Journal article 2019
Journal article

2018

Showing 1 - 10 of 25

Page Manager: Karin Allander|Last update: 9/19/2019
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