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Ulf Lerner

Anställd

Ulf Lerner

ulf.lerner@gu.se
+46 31-342 6534

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Vita stråket su , Göteborg


Department of Internal Medicine and Clinical Nutrition at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
0313421000
Fax: +46 317863101
Visiting Address: Vita stråket SU , 413 45 Göteborg

About Ulf Lerner

Professor of Oral Cell Biology at Umeå University since 1991 (currently 50%) and guest professor at Sahlgrenska Academy since 2010 (50%). Priniciple investigator for a group of 8 people in Umeå and 2 people at Sahlgrenska Academy for cell- and molecular studies on differentiation and function of bone forming osteoblasts and bone resorbing osteoclasts.

Main Research Topic

Main research areas are regulation of bone resorption and bone formation by inflammatory processes and by steroid hormones, including effects on the bone cells by pro- and antiinflammatory osteotropic cytokines, kinins, glucocorticoids and retinoids. The studies involve also molecular mechanisms by which these signalling molecules exert their effects intracellularly. A third area is the effect by cysteine proteinase inhibitors on osteoclast differentiation and function.

PhD Students
Fredrik Strålberg
Amir Pirhayati
Ali Kassem

Latest publications

High Plasma Erythropoietin Predicts Incident Fractures in Elderly Men with Normal Renal Function: The MrOS Sweden Cohort.
Hallgerdur Lind Kristjansdottir, Catharina Lewerin, Ulf H Lerner, Hans Herlitz, Peter Johansson et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Journal article 2020
Journal article

Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.
H Herschel Conaway, Petra Henning, Antia Lie, Jan Tuckermann, Ulf H Lerner
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Osteoclasts in Health and Disease.
Ulf H Lerner
Pediatric endocrinology reviews : PER, Journal article 2019
Journal article

The critical interplay between bone resorbing and bone forming cells
Ulf H Lerner, E. Kindstedt, P. Lundberg
Journal of Clinical Periodontology, Journal article 2019
Journal article

Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva
P. P. C. Souza, P. Lundberg, I. Lundgren, F. A. C. Magalhaes, C. M. Costa-Neto et al.
Scientific Reports, Journal article 2019
Journal article

NOTUM inhibition increases endocortical bone formation and bone strength
Robert Brommage, J. Liu, P. Vogel, F. Mseeh, A. Y. Thompson et al.
Bone Research, Journal article 2019
Journal article

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J. Zheng, W. Maerz, I. Gergei, M. Kleber, C. Drechsler et al.
Journal of Bone and Mineral Research, Journal article 2019
Journal article

Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
E. Persson, P. P. C. Souza, T. Floriano-Marcelino, H. H. Conaway, Petra Henning et al.
Frontiers in Immunology, Journal article 2019
Journal article

Showing 41 - 50 of 107

2015

2014

Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden.
Catharina Lewerin, Herman Nilsson-Ehle, Stefan Jacobsson, Helena Johansson, Valter Sundh et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Journal article 2014
Journal article

2013

The role of cytokines in inflammatory bone loss.
Pedro P C Souza, Ulf H Lerner
Immunological investigations, Journal article 2013
Journal article

Cysteine proteinase inhibitors regulate human and mouse osteoclastogenesis by interfering with RANK signaling.
Fredrik Strålberg, Petra Henning, Inger Gjertsson, Bert Kindlund, Pedro P C Souza et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2013
Journal article

Inhibition of the insulin-like growth factor-1 receptor enhances effects of simvastatin on prostate cancer cells in co-culture with bone.
Annika Nordstrand, Marie Lundholm, Andreas Larsson, Ulf H Lerner, Anders Widmark et al.
Cancer microenvironment : official journal of the International Cancer Microenvironment Society, Journal article 2013
Journal article

IL-4 and IL-13 inhibit IL-1 beta and TNF-alpha induced kinin B-1 and B-2 receptors through a STAT6-dependent mechanism
P. P. C. Souza, A. B. Brechter, R. I. Reis, C. A. S. Costa, P. Lundberg et al.
British Journal of Pharmacology, Journal article 2013
Journal article

Showing 41 - 50 of 107

Page Manager: Karin Allander|Last update: 9/19/2019
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