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Ulf Lerner

Anställd

Ulf Lerner

ulf.lerner@gu.se
+46 31-342 6534

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Vita stråket su , Göteborg


Department of Internal Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
0313421000
Fax: +46 317863101
Visiting Address: Vita stråket SU , 413 45 Göteborg

About Ulf Lerner

Professor of Oral Cell Biology at Umeå University since 1991 (currently 50%) and guest professor at Sahlgrenska Academy since 2010 (50%). Priniciple investigator for a group of 8 people in Umeå and 2 people at Sahlgrenska Academy for cell- and molecular studies on differentiation and function of bone forming osteoblasts and bone resorbing osteoclasts.

Main Research Topic

Main research areas are regulation of bone resorption and bone formation by inflammatory processes and by steroid hormones, including effects on the bone cells by pro- and antiinflammatory osteotropic cytokines, kinins, glucocorticoids and retinoids. The studies involve also molecular mechanisms by which these signalling molecules exert their effects intracellularly. A third area is the effect by cysteine proteinase inhibitors on osteoclast differentiation and function.

PhD Students
Fredrik Strålberg
Amir Pirhayati
Ali Kassem

Latest publications

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J. Zheng, W. Maerz, I. Gergei, M. Kleber, C. Drechsler et al.
Journal of Bone and Mineral Research, Journal article 2019
Journal article

Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
E. Persson, P. P. C. Souza, T. Floriano-Marcelino, H. H. Conaway, Petra Henning et al.
Frontiers in Immunology, Journal article 2019
Journal article

The critical interplay between bone resorbing and bone forming cells
Ulf H Lerner, E. Kindstedt, P. Lundberg
Journal of Clinical Periodontology, Journal article 2019
Journal article

Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation
Vikte Lionikaite, Petra Henning, Christina Drevinge, Furqan A. Shah, Anders Palmquist et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
M. Pekkinen, P. A. Terhal, L. D. Botto, Petra Henning, R. E. Makitie et al.
Jci Insight, Journal article 2019
Journal article

Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva
P. P. C. Souza, P. Lundberg, I. Lundgren, F. A. C. Magalhaes, C. M. Costa-Neto et al.
Scientific Reports, Journal article 2019
Journal article

NOTUM inhibition increases endocortical bone formation and bone strength
Robert Brommage, J. Liu, P. Vogel, F. Mseeh, A. Y. Thompson et al.
Bone Research, Journal article 2019
Journal article

Showing 51 - 60 of 103

2012

High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden.
Helena Johansson, Anders Odén, Ulf H Lerner, Hans Jutberger, Mattias Lorentzon et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Journal article 2012
Journal article

Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts.
Pedro P C Souza, Py Palmqvist, Pernilla Lundberg, Inger Lundgren, Lennart Hänström et al.
Molecular immunology, Journal article 2012
Journal article

2011

Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor.
H Herschel Conaway, Amir Pirhayati, Emma Persson, Ulrika Pettersson, Olle Svensson et al.
The Journal of biological chemistry, Journal article 2011
Journal article

2010

Cytokine responses against periodontal infection: protective and destructive roles.
Yen-Chun G Liu, Ulf H Lerner, Yen-Tung A Teng
Periodontology 2000, Journal article 2010
Journal article

Development of a novel poly bisphosphonate conjugate for treatment of skeletal metastasis and osteoporosis.
Anders R Holmberg, Ulf H Lerner, Ayodele A Alayia, Mai Al-Mohanna, Chaker Adra et al.
International journal of oncology, Journal article 2010
Journal article

Showing 51 - 60 of 103

Page Manager: Karin Allander|Last update: 9/19/2019
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