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Ulf Lerner


Ulf Lerner

+46 31-342 6534

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Vita stråket su , Göteborg

Department of Internal Medicine at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 317863101
Visiting Address: Vita stråket SU , 413 45 Göteborg

About Ulf Lerner

Professor of Oral Cell Biology at Umeå University since 1991 (currently 50%) and guest professor at Sahlgrenska Academy since 2010 (50%). Priniciple investigator for a group of 8 people in Umeå and 2 people at Sahlgrenska Academy for cell- and molecular studies on differentiation and function of bone forming osteoblasts and bone resorbing osteoclasts.

Main Research Topic

Main research areas are regulation of bone resorption and bone formation by inflammatory processes and by steroid hormones, including effects on the bone cells by pro- and antiinflammatory osteotropic cytokines, kinins, glucocorticoids and retinoids. The studies involve also molecular mechanisms by which these signalling molecules exert their effects intracellularly. A third area is the effect by cysteine proteinase inhibitors on osteoclast differentiation and function.

PhD Students
Fredrik Strålberg
Amir Pirhayati
Ali Kassem

Latest publications

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J. Zheng, W. Maerz, I. Gergei, M. Kleber, C. Drechsler et al.
Journal of Bone and Mineral Research, Journal article 2019
Journal article

Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
E. Persson, P. P. C. Souza, T. Floriano-Marcelino, H. H. Conaway, Petra Henning et al.
Frontiers in Immunology, Journal article 2019
Journal article

The critical interplay between bone resorbing and bone forming cells
Ulf H Lerner, E. Kindstedt, P. Lundberg
Journal of Clinical Periodontology, Journal article 2019
Journal article

Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation
Vikte Lionikaite, Petra Henning, Christina Drevinge, Furqan A. Shah, Anders Palmquist et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2
M. Pekkinen, P. A. Terhal, L. D. Botto, Petra Henning, R. E. Makitie et al.
Jci Insight, Journal article 2019
Journal article

Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva
P. P. C. Souza, P. Lundberg, I. Lundgren, F. A. C. Magalhaes, C. M. Costa-Neto et al.
Scientific Reports, Journal article 2019
Journal article

NOTUM inhibition increases endocortical bone formation and bone strength
Robert Brommage, J. Liu, P. Vogel, F. Mseeh, A. Y. Thompson et al.
Bone Research, Journal article 2019
Journal article

Showing 61 - 70 of 103


Stimulation of IL-6 type of cytokines in gingival fibroblasts by Toll-like 2 receptors
PCC Souza, P Palmqvist, I Lundgren, A Lie, CM Costa-Neto et al.
Journal of dental research, Journal article 2010
Journal article

Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women.
Maria Swanberg, Fiona McGuigan, Kaisa K Ivaska, Paul Gerdhem, Ulf H Lerner et al.
Bone, Journal article 2010
Journal article

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Alexander Rauch, Sebastian Seitz, Ulrike Baschant, Arndt F Schilling, Anett Illing et al.
Cell metabolism, Journal article 2010
Journal article

Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients.
S Crnalic, E Hörnberg, P Wikström, Ulf H Lerner, A Tieva et al.
Endocrine-related cancer, Journal article 2010
Journal article


Retinoids inhibit differentiation of hematopoietic osteoclast progenitors.
H Herschel Conaway, Emma Persson, Marie Halén, Susanne Granholm, Olle Svensson et al.
The FASEB journal, Journal article 2009
Journal article

Establishment and validation of an in vitro co-culture model to study the interactions between bone and prostate cancer cells.
Annika Nordstrand, Jonas Nilsson, Ase Tieva, Pernilla Wikström, Ulf H Lerner et al.
Clinical & experimental metastasis, Journal article 2009
Journal article

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction.
Anders Holmlund, Måns Hedin, Pirkko J Pussinen, Ulf H Lerner, Lars Lind
International journal of cardiology, Journal article 2009
Journal article


IL-1beta and TNF-alpha regulate IL-6-type cytokines in gingival fibroblasts.
P Palmqvist, P Lundberg, I Lundgren, L Hänström, Ulf H Lerner
Journal of dental research, Journal article 2008
Journal article

Kinins and neuro-osteogenic factors
Ulf H Lerner, E Persson, P Lundberg
Principles of bone biology. 3rd edition, San Diego, Acadamic Press, Chapter in book 2008
Chapter in book

Showing 61 - 70 of 103

Page Manager: Karin Allander|Last update: 9/19/2019

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