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Ulf Lerner


Ulf Lerner

+46 31-342 6534

Postal Address: Su sahlgrenska, 41345 Göteborg
Visiting Address: Vita stråket su , Göteborg

Department of Internal Medicine and Clinical Nutrition at Institute of Medicine (More Information)
SU Sahlgrenska
413 45 Göteborg
Fax: +46 317863101
Visiting Address: Vita stråket SU , 413 45 Göteborg

About Ulf Lerner

Professor of Oral Cell Biology at Umeå University since 1991 (currently 50%) and guest professor at Sahlgrenska Academy since 2010 (50%). Priniciple investigator for a group of 8 people in Umeå and 2 people at Sahlgrenska Academy for cell- and molecular studies on differentiation and function of bone forming osteoblasts and bone resorbing osteoclasts.

Main Research Topic

Main research areas are regulation of bone resorption and bone formation by inflammatory processes and by steroid hormones, including effects on the bone cells by pro- and antiinflammatory osteotropic cytokines, kinins, glucocorticoids and retinoids. The studies involve also molecular mechanisms by which these signalling molecules exert their effects intracellularly. A third area is the effect by cysteine proteinase inhibitors on osteoclast differentiation and function.

PhD Students
Fredrik Strålberg
Amir Pirhayati
Ali Kassem

Latest publications

High Plasma Erythropoietin Predicts Incident Fractures in Elderly Men with Normal Renal Function: The MrOS Sweden Cohort.
Hallgerdur Lind Kristjansdottir, Catharina Lewerin, Ulf H Lerner, Hans Herlitz, Peter Johansson et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Journal article 2020
Journal article

Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis.
H Herschel Conaway, Petra Henning, Antia Lie, Jan Tuckermann, Ulf H Lerner
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Journal article 2019
Journal article

Osteoclasts in Health and Disease.
Ulf H Lerner
Pediatric endocrinology reviews : PER, Journal article 2019
Journal article

The critical interplay between bone resorbing and bone forming cells
Ulf H Lerner, E. Kindstedt, P. Lundberg
Journal of Clinical Periodontology, Journal article 2019
Journal article

Activation of Toll-like receptor 2 induces B1 and B2 kinin receptors in human gingival fibroblasts and in mouse gingiva
P. P. C. Souza, P. Lundberg, I. Lundgren, F. A. C. Magalhaes, C. M. Costa-Neto et al.
Scientific Reports, Journal article 2019
Journal article

NOTUM inhibition increases endocortical bone formation and bone strength
Robert Brommage, J. Liu, P. Vogel, F. Mseeh, A. Y. Thompson et al.
Bone Research, Journal article 2019
Journal article

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J. Zheng, W. Maerz, I. Gergei, M. Kleber, C. Drechsler et al.
Journal of Bone and Mineral Research, Journal article 2019
Journal article

Activation of Shc1 allows oncostatin M to induce RANKL and osteoclast formation more effectively than leukemia inhibitory factor
E. Persson, P. P. C. Souza, T. Floriano-Marcelino, H. H. Conaway, Petra Henning et al.
Frontiers in Immunology, Journal article 2019
Journal article

Showing 61 - 70 of 107



Cytokine responses against periodontal infection: protective and destructive roles.
Yen-Chun G Liu, Ulf H Lerner, Yen-Tung A Teng
Periodontology 2000, Journal article 2010
Journal article

Development of a novel poly bisphosphonate conjugate for treatment of skeletal metastasis and osteoporosis.
Anders R Holmberg, Ulf H Lerner, Ayodele A Alayia, Mai Al-Mohanna, Chaker Adra et al.
International journal of oncology, Journal article 2010
Journal article

Stimulation of IL-6 type of cytokines in gingival fibroblasts by Toll-like 2 receptors
PCC Souza, P Palmqvist, I Lundgren, A Lie, CM Costa-Neto et al.
Journal of dental research, Journal article 2010
Journal article

Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women.
Maria Swanberg, Fiona McGuigan, Kaisa K Ivaska, Paul Gerdhem, Ulf H Lerner et al.
Bone, Journal article 2010
Journal article

Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
Alexander Rauch, Sebastian Seitz, Ulrike Baschant, Arndt F Schilling, Anett Illing et al.
Cell metabolism, Journal article 2010
Journal article

Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients.
S Crnalic, E Hörnberg, P Wikström, Ulf H Lerner, A Tieva et al.
Endocrine-related cancer, Journal article 2010
Journal article


Retinoids inhibit differentiation of hematopoietic osteoclast progenitors.
H Herschel Conaway, Emma Persson, Marie Halén, Susanne Granholm, Olle Svensson et al.
The FASEB journal, Journal article 2009
Journal article

Establishment and validation of an in vitro co-culture model to study the interactions between bone and prostate cancer cells.
Annika Nordstrand, Jonas Nilsson, Ase Tieva, Pernilla Wikström, Ulf H Lerner et al.
Clinical & experimental metastasis, Journal article 2009
Journal article

Showing 61 - 70 of 107

Page Manager: Karin Allander|Last update: 9/19/2019

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