Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Anna Rudin

Professor/ chief physician

Anna Rudin
Professor/ chief physician , Deputy Head
anna.rudin@microbio.gu.se

Postal Address: Box 428, 40530 Göteborg
Visiting Address: Medicinaregatan 3, plan 5 , 41390 Göteborg


Institute of Medicine (More Information)
Box 428
405 30 Göteborg
www.medicine.gu.se
medicin@gu.se
Fax: +46 31823925
Visiting Address: Medicinaregatan 3, plan 5 , 413 90 Göteborg

About Anna Rudin

Anna Rudin is Deputy Head of Institute of Medicine, full professor in inflammation research and senior consultant in rheumatology.

She combines experimental work on human samples from patients and healthy controls at the Dept of Rheumatology and Inflammation Research with clinical work on patients with rheumatic diseases at the rheumatology clinic, Sahlgrenska University Hospital. She is also associated to IMED/RIA at AstraZeneca, Gothenburg, where she functions as academic and clinical consultant and collaborator since 2014.

Biography

  • MD University of Gothenburg 1985
  • Licensed physician 1990
  • PhD in microbiology and immunology University of Gothenburg 1996
  • Postdoc at Telethon Institute of Child Health research, Perth, Australia 1999
  • Associate professor in immunology 2001
  • Consultant in rheumatology 2009
  • Adjunct professor in inflammation research 2010
  • Senior consultant in rheumatology 2014,
  • Professor in inflammation research University of Gothenburg 2014.
  • Main supervisor of seven PhD students, the first graduated as PhD in 2004 and the last in 2017, and main supervisor of four post docs.

Research

The overall aim of our work is to unravel the immunopathogenesis in the early phases of allergic and rheumatic diseases, exclusively in humans. To reach this goal we study prospective cohorts starting before diagnosis, early after diagnosis or during established disease and collect samples from blood, synovial fluid and synovial biopsies. Our work is translational with close collaboration between experimental and clinical researchers.

We collect birth cohorts to study allergic disease, early rheumatoid arthritis patient cohorts and systemic lupus erythematosus patient cohorts and investigate clinical, immunological and environmental factors in relation to disease development and outcomes. We also study the effect of different treatments in rheumatoid arthritis and the relation of treatment outcomes and immunological biomarkers.

A major recent discovery we have made in the birth cohorts is that increased proportions of circulating transitional/naïve B-cells already at birth predicts allergy development in both infants and children up to 8 years of age. Also, the cytokine BAFF, B-cell activating factor, is found in lower levels at birth in children who develop allergy. Another novel discovery is that human placental stromal cells secrete BAFF in response to interferons, and that children born of mothers exposed to a dairy farm environment during pregnancy have higher BAFF levels in blood at birth.

With regards to early untreated rheumatoid arthritis we have recently reported that the T cell subtype profile in blood is dominated by Th2 and Th17 cells, which points to their importance in the pathogenesis. Th2 cells have previously been poorly studied in early rheumatoid arthritis. Further, we have shown that the interferon-induced chemokine CXCL10 in blood is related to the degree of disease activity in early rheumatoid arthritis, but none of the T-cells subtypes.

Major publications

Allergic disease in 8-year old children is preceded by delayed B-cell maturation.
Anna Strömbeck, Inger Nordström, Kerstin Andersson, Helen Andersson, Susanne Johansen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017

Latest publications

Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study
A. L. Herrick, S. Peytrignet, M. Lunt, X. Pan, R. Hesselstrand et al.
Annals of the Rheumatic Diseases, Journal article 2018
Journal article

Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon et al.
Rheumatology (Oxford, England), Journal article 2018
Journal article

Allergic disease in 8-year old children is preceded by delayed B-cell maturation.
Anna Strömbeck, Inger Nordström, Kerstin Andersson, Helen Andersson, Susanne Johansen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Journal article 2017
Journal article

Major publications

Allergic disease in 8-year old children is preceded by delayed B-cell maturation.
Anna Strömbeck, Inger Nordström, Kerstin Andersson, Helen Andersson, Susanne Johansen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017

Showing 1 - 10 of 51

2018

Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study
A. L. Herrick, S. Peytrignet, M. Lunt, X. Pan, R. Hesselstrand et al.
Annals of the Rheumatic Diseases, Journal article 2018
Journal article

Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon et al.
Rheumatology (Oxford, England), Journal article 2018
Journal article

2017

Allergic disease in 8-year old children is preceded by delayed B-cell maturation.
Anna Strömbeck, Inger Nordström, Kerstin Andersson, Helen Andersson, Susanne Johansen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Journal article 2017
Journal article

Showing 1 - 10 of 51

Page Manager: Karin Allander|Last update: 10/1/2019
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?