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- Huamei Forsman
Huamei Forsman
Professor, adjungerad
Avdelningen förOm Huamei Forsman
Huamei Forsman disputerade inom ämnesområdet "naturlig immunitet" 2004 och gjorde därefter en "postdoc" på Dana-Farber Cancer Institute, Boston hos Professor Koichi Kobayashi. År 2013 erhöll jag ett anslag från Vetenskapsrådet och jag har sedan dess arbetat med att etablera en egen forskningsgrupp. Gruppens målsättning är förstå hur inflammationsprocessen regleras och vilken roll så kallade G-protein kopplade receptorer har i den regleringen, såväl när den fungerar som när balansen ibland störs och leder till inflammatoriska sjukdomstillstånd.
Inflammationsprocessen är central för vår hälsa genom att den effektivt försvarar oss mot invaderande mikroorganismer. Samtidigt kan denna process också orsaka skada och sjukdom. Det är alltså oerhört viktigt att inflammationsprocessen kontrolleras och balanseras på ett effektivt sätt.
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Larixol is not an inhibitor of Gα<inf>i</inf> containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide
receptors
Lena Björkman, Huamei Forsman, Linda Bergqvist, Claes Dahlgren, Martina Sundqvist
Biochemical Pharmacology - 2024 -
The characterization of CD8+ T-cell responses in
COVID-19
Yuanting Yang, Heather Miller, Maria G. Byazrova, Fabio Cndotti, Kamel Benlagha, Niels Olsen Saraiva Camara, Junming Shi, Huamei Forsman, Pamela Lee, Lu Yang, Alexander Filatov, Zhimin Zhai, Chaohong Liu
EMERGING MICROBES & INFECTIONS - 2024 -
Ultra-high static magnetic fields cause immunosuppression through disrupting B-cell peripheral differentiation and negatively regulating BCR
signaling
H. Gu, Y. F. Fu, B. Yu, L. Luo, D. Q. Kang, M. M. Xie, Y. K. Jing, Q. Y. Chen, X. Zhang, J. Lai, F. Guan, Huamei Forsman, J. M. Shi, L. Yang, J. H. Lei, X. R. Du, X. Zhang, C. H. Liu
Medcomm - 2023 -
The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil
GPCRs
Simon Lind, K. L. Granberg, Huamei Forsman, Claes Dahlgren
Plos One - 2023 -
Function and regulation of GPR84 in human
neutrophils
Huamei Forsman, Claes Dahlgren, Jonas Mårtensson, Lena Björkman, Martina Sundqvist
British Journal of Pharmacology - 2023 -
The ketone body acetoacetate activates human neutrophils through
FFAR2.
Jonas Mårtensson, Lena Björkman, Simon Lind, Moa Viklund, Linjie Zhang, Saray Gutierrez, Claes Dahlgren, Martina Sundqvist, Xin Xie, Huamei Forsman
Journal of leukocyte biology - 2023 -
An increase in the cytosolic concentration of free calcium ions activates the neutrophil NADPH-oxidase provided that the free fatty acid receptor 2 has been allosterically
modulated.
Simon Lind, Yanling Wu, Martina Sundqvist, Huamei Forsman, Claes Dahlgren
Cellular signalling - 2023 -
AZ2158 is a more potent formyl peptide receptor 1 inhibitor than the commonly used peptide antagonists in abolishing neutrophil
chemotaxis.
Huamei Forsman, Yanling Wu, Jonas Mårtensson, Lena Björkman, Kenneth L Granberg, Claes Dahlgren, Martina Sundqvist
Biochemical pharmacology - 2023 -
Structural Determinants in the Staphylococcus aureus-Derived Phenol-Soluble Modulin α2 Peptide Required for Neutrophil Formyl Peptide Receptor
Activation
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind, H. Franzyk, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Journal of Immunology - 2022 -
G protein coupled pattern recognition receptors expressed in neutrophils: Recognition, activation/modulation, signaling and receptor regulated
functions.
Claes Dahlgren, Simon Lind, Jonas Mårtensson, Lena Björkman, Yanling Wu, Martina Sundqvist, Huamei Forsman
Immunological reviews - 2022 -
Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B
cells.
Alessandro Camponeschi, Kathrin Kläsener, Timothy Sundell, Christina Lundqvist, Paul T Manna, Negar Ayoubzadeh, Martina Sundqvist, Katrin Thorarinsdottir, Mariele Gatto, Marcella Visentini, Karin Önnheim, Alaitz Aranburu, Huamei Forsman, Olov Ekwall, Linda Fogelstrand, Inger Gjertsson, Michael Reth, Inga-Lill Mårtensson
The Journal of experimental medicine - 2022 -
Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic
arthritis.
Zhicheng Hu, Pradeep Kumar Kopparapu, Patrick Ebner, Majd Mohammad, Simon Lind, Anders Jarneborn, Claes Dahlgren, Michelle Schultz, Megshree Deshmukh, Rille Pullerits, Mulugeta Nega, Minh-Thu Nguyen, Ying Fei, Huamei Forsman, Friedrich Götz, Tao Jin
Communications biology - 2022 -
GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by beta-arrestin recruiting GPR84
agonists
Johanna Fredriksson, André Holdfeldt, Jonas Mårtensson, Lena Björkman, T. C. Moller, E. Mullers, Claes Dahlgren, Martina Sundqvist, Huamei Forsman
Biochimica Et Biophysica Acta-Molecular Cell Research - 2022 -
The Two Formyl Peptide Receptors Differently Regulate GPR84-Mediated Neutrophil NADPH Oxidase
Activity
Jonas Mårtensson, Martina Sundqvist, A. Manandhar, L. Leremias, L. J. Zhang, T. Ulven, X. Xie, Lena Björkman, Huamei Forsman
Journal of Innate Immunity - 2021 -
Allosteric receptor modulation uncovers an FFA2R antagonist as a positive orthosteric modulator/agonist in
disguise.
Simon Lind, Dagny Olofsson Hoffmann, Huamei Forsman, Claes Dahlgren
Cellular signalling - 2021 -
Porphyromonas gingivalis Produce Neutrophil Specific Chemoattractants Including Short Chain Fatty
Acids.
Agnes Dahlstrand Rudin, Arsham Khamzeh, Vignes Venkatakrishnan, Tishana Persson, Michael Gabl, Otto Savolainen, Huamei Forsman, Claes Dahlgren, Karin Christenson, Johan Bylund
Frontiers in cellular and infection microbiology - 2021 -
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation
patterns.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Kenneth L Granberg, Huamei Forsman, Claes Dahlgren
Biochemical pharmacology - 2021 -
Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated
Functions
Claes Dahlgren, André Holdfeldt, Simon Lind, Jonas Mårtensson, Michael Gabl, Lena Björkman, Martina Sundqvist, Huamei Forsman
ACS Pharmacology and Translational Science - 2020 -
The PAR4-derived pepducin P4Pal10 lacks effect on neutrophil GPCRs that couple to Gαq for signaling but distinctly modulates function of the Gαi-coupled FPR2 and
FFAR2
André Holdfeldt, Simon Lind, Camilla Hesse, Claes Dahlgren, Huamei Forsman
Biochemical Pharmacology - 2020 -
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor
endocytosis
Martina Sundqvist, André Holdfeldt, S. C. Wright, T. C. Moller, Esther Siaw, K. Jennbacken, H. Franzyk, M. Bouvier, Claes Dahlgren, Huamei Forsman
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in
neutrophils
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Biochimica Et Biophysica Acta-Molecular Cell Research - 2020 -
Data showing effects of a PI3K-delta inhibitor on neutrophil superoxide production during FPR2 activation and
reactivation
André Holdfeldt, Martina Sundqvist, Claes Dahlgren, Huamei Forsman
Data in Brief - 2020 -
Data describing expression of formyl peptide receptor 2 in human articular
chondrocytes
Alexander Strid Holmertz, Charlotte A Jonsson, Maziar Mohaddes, Christina Lundqvist, Huamei Forsman, Inger Gjertsson, Karin Önnheim
Data in Brief - 2020 -
Functional selective ATP receptor signaling controlled by the free fatty acid receptor 2 through a novel allosteric modulation
mechanism.
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Lena Björkman, Huamei Forsman, Claes Dahlgren
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome
b.
Simon Lind, Michael Gabl, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology (Baltimore, Md. : 1950) - 2019 -
Functional characteristics of circulating granulocytes in severe congenital neutropenia caused by ELANE
mutations
Q. Liu, Martina Sundqvist, W. Y. Li, André Holdfeldt, L. Zhang, Lena Björkman, Johan Bylund, Claes Dahlgren, C. Wang, X. D. Zhao, Huamei Forsman
Bmc Pediatrics - 2019 -
Functional and signaling characterization of the neutrophil FPR2 selective agonist
Act-389949
Simon Lind, Martina Sundqvist, R. Holmdahl, Claes Dahlgren, Huamei Forsman, P. Olofsson
Biochemical Pharmacology - 2019 -
Neutrophil recruitment to inflamed joints can occur without cellular
priming.
Lena Björkman, Karin Christenson, Lisa Davidsson, Jonas Mårtensson, Firoozeh Amirbeagi, Amanda Welin, Huamei Forsman, Anna Karlsson, Claes Dahlgren, Johan Bylund
Journal of leukocyte biology - 2019 -
Staphylococcus aureus-Derived PSMα Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate β-Arrestin Recruitment and
Chemotaxis.
Martina Sundqvist, Karin Christenson, André Holdfeldt, Karin Jennbacken, Thor C Møller, Claes Dahlgren, Huamei Forsman
Journal of immunology - 2019 -
Formyl peptide receptor 2 orchestrates mucosal protection against Citrobacter rodentium
infection
Sinan Sharba, Vignes Venkatakrishnan, Médea Padra, Malene Winther, Michael Gabl, Martina Sundqvist, J. Wang, Huamei Forsman, Sara K. Lindén
Virulence - 2019 -
Structure-Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect
Function
André Holdfeldt, S. L. Skovbakke, Michael Gabl, C. Nielsen, Claes Dahlgren, H. Franzyk, Huamei Forsman
ACS Omega - 2019 -
Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating
NADPH-oxidase
Jonas Mårtensson, André Holdfeldt, Martina Sundqvist, Michael Gabl, T. P. Kenakin, Lena Björkman, Huamei Forsman, Claes Dahlgren
Journal of leukocyte biology - 2018 -
Lack of Receptor for Advanced Glycation End products leads to less severe staphylococcal skin infection but more skin abscesses and prolonged wound
healing.
Manli Na, Majd Mohammad, Ying Fei, Wanzhong Wang, André Holdfeldt, Huamei Forsman, Abukar Ali, Rille Pullerits, Tao Jin
The Journal of infectious diseases - 2018 -
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling
Properties.
Michael Gabl, Martina Sundqvist, André Holdfeldt, Simon Lind, Jonas Mårtensson, Karin Christenson, Takayuki Marutani, Claes Dahlgren, Hidehito Mukai, Huamei Forsman
Journal of immunology - 2018 -
The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and
Peptidomimetics
S. L. Skovbakke, André Holdfeldt, Huamei Forsman, Johan Bylund, H. Franzyk
Current Pharmaceutical Design - 2018 -
Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating
Lipopeptides.
Malene Winther, Claes Dahlgren, Huamei Forsman
Basic & clinical pharmacology & toxicology - 2018 -
Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor
FFA2R.
Martina Sundqvist, Karin Christenson, André Holdfeldt, Michael Gabl, Jonas Mårtensson, Lena Björkman, Regis Dieckmann, Claes Dahlgren, Huamei Forsman
Biochimica et biophysica acta - 2018 -
FPR2 signaling without β-arrestin recruitment alters the functional repertoire of
neutrophils.
Michael Gabl, André Holdfeldt, Martina Sundqvist, Jalal Lomei, Claes Dahlgren, Huamei Forsman
Biochemical pharmacology - 2017 -
Phenol-Soluble Modulin α Peptide Toxins from Aggressive Staphylococcus aureus Induce Rapid Formation of Neutrophil Extracellular Traps through a Reactive Oxygen Species-Independent
Pathway.
Halla Björnsdottir, Agnes Dahlstrand Rudin, Felix P Klose, Jonas Elmwall, Amanda Welin, Marios Stylianou, Karin Christenson, Constantin F Urban, Huamei Forsman, Claes Dahlgren, Anna Karlsson, Johan Bylund
Frontiers in immunology - 2017 -
Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in
question
Malene Winther, André Holdfeldt, Martina Sundqvist, Zahra Rajabkhani, Michael Gabl, Johan Bylund, Claes Dahlgren, Huamei Forsman
Plos One - 2017 -
Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic
Antagonists.
Sarah Line Skovbakke, André Holdfeldt, Christina Nielsen, Anna Mette Hansen, Iris Perez-Gassol, Claes Dahlgren, Huamei Forsman, Henrik Franzyk
Journal of medicinal chemistry - 2017 -
Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor
receptor.
André Holdfeldt, Agnes Dahlstrand Rudin, Michael Gabl, Zahra Rajabkhani, Gabriele M König, Evi Kostenis, Claes Dahlgren, Huamei Forsman
Journal of Leukocyte Biology - 2017 -
Data on the NADPH-oxidase activity induced by WKYMVm and galectin-3 in bone marrow derived and exudated neutrophils isolated from four different mouse
strains.
Lena Björkman, Huamei Forsman, Karin Önnheim
Data in brief - 2017 -
Formylated MHC Class lb Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor
1
Malene Winther, André Holdfeldt, Michael Gabl, J. M. Wang, Huamei Forsman, Claes Dahlgren
PLoS ONE - 2016 -
The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue
Recruitment
Lena Björkman, Jonas Martensson, Malene Winther, Michael Gabl, André Holdfeldt, Martin Uhrbom, Johan Bylund, A. H. Hansen, S. K. Pandey, T. Ulven, Huamei Forsman, Claes Dahlgren
Molecular and Cellular Biology - 2016 -
The lipidated peptidomimetic Lau-[(S)-Aoc]-(Lys-βNphe)6-NH2 is a novel formyl peptide receptor 2 agonist that activates both human and mouse neutrophil
NADPH-oxidase.
André Holdfeldt, Sarah Line Skovbakke, Malene Winther, Michael Gabl, Christina Nielsen, Iris Perez-Gassol, Camilla Josephine Larsen, Ji Ming Wang, Anna Karlsson, Claes Dahlgren, Huamei Forsman, Henrik Franzyk
The Journal of biological chemistry - 2016 -
A pepducin designed to modulate P2Y2R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk
mechanism.
Michael Gabl, André Holdfeldt, Malene Winther, Tudor I Oprea, Johan Bylund, Claes Dahlgren, Huamei Forsman
Biochimica et biophysica acta - 2016 -
The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse
neutrophils.
Sarah Line Skovbakke, Malene Winther, Michael Gabl, André Holdfeldt, Sara K. Lindén, Ji Ming Wang, Claes Dahlgren, Henrik Franzyk, Huamei Forsman
Biochemical pharmacology - 2016 -
Data on human neutrophil activation induced by pepducins with amino acid sequences derived from β2AR and
CXCR4.
André Holdfeldt, Malene Winther, Michael Gabl, Claes Dahlgren, Huamei Forsman
Data in brief - 2016 -
Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and
mitochondria.
Claes Dahlgren, Michael Gabl, André Holdfeldt, Malene Winther, Huamei Forsman
Biochemical pharmacology - 2016 -
P2Y2 receptor signaling in neutrophils Is regulated from inside by a novel cytoskeleton-dependent
mechanism.
Michael Gabl, Malene Winther, Amanda Welin, Anna Karlsson, Tudor I Oprea, Johan Bylund, Claes Dahlgren, Huamei Forsman
Experimental cell research - 2015 -
The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor
2.
Sarah Line Skovbakke, Peter M H Heegaard, Camilla J Larsen, Henrik Franzyk, Huamei Forsman, Claes Dahlgren
Biochemical pharmacology - 2015 -
IL-4 Protects the Mitochondria Against TNF alpha and IFN gamma Induced Insult During Clearance of Infection with Citrobacter rodentium and Escherichia
coli
Arpan K. Maiti, Sinan Sharba, Nazanin Navabi, Huamei Forsman, Harvey Robert Fernandez, Sara K. Lindén
Scientific Reports - 2015 -
A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2
instead
Malene Winther, Michael Gabl, Amanda Welin, Claes Dahlgren, Huamei Forsman
Febs Letters - 2015 -
CFP-10 from Mycobacterium tuberculosis Selectively Activates Human Neutrophils through a Pertussis Toxin-Sensitive Chemotactic
Receptor.
Amanda Welin, Halla Björnsdottir, Malene Winther, Karin Christenson, Tudor I Oprea, Anna Karlsson, Huamei Forsman, Claes Dahlgren, Johan Bylund
Infection and immunity - 2015 -
Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl
group.
Huamei Forsman, Malene Winther, Michael Gabl, Sarah Line Skovbakke, Francois Boulay, Marie-Josèphe Rabiet, Claes Dahlgren
Biochimica et biophysica acta - 2015 -
Turning Chemoattractant Receptors On and Off with Conventional Ligands and Allosteric Modulators: Recent advances in formyl peptide receptor signaling and
regulation
Johan Bylund, Michael Gabl, Malene Winther, Karin Önnheim, Claes Dahlgren, Huamei Forsman
Inflammation and cell signaling - 2014 -
Antibacterial activity of pepducins, allosterical modulators of formyl Peptide receptor
signaling.
Malene Winther, Michael Gabl, Tudor I Oprea, Bodil Jönsson, Francois Boulay, Johan Bylund, Claes Dahlgren, Huamei Forsman
Antimicrobial agents and chemotherapy - 2014 -
A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of
FPR2
Michael Gabl, Malene Winther, Sarah Line Skovbakke, Johan Bylund, Claes Dahlgren, Huamei Forsman
Plos One - 2014 -
The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on
arthritis.
Cecilia Engdahl, Anna E Börjesson, Huamei Forsman, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist
Arthritis research & therapy - 2014 -
A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce
superoxide.
Karin Önnheim, Karin Christenson, Michael Gabl, Joachim C Burbiel, Christa E Müller, Tudor I Oprea, Johan Bylund, Claes Dahlgren, Huamei Forsman
Experimental cell research - 2014 -
The Subcellular Localization of the Receptor for Platelet-Activating Factor in Neutrophils Affects Signaling and Activation
Characteristics
Emil Andréasson, Karin Önnheim, Huamei Forsman
Clinical & Developmental Immunology - 2013 -
The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor
loop.
Huamei Forsman, Johan Bylund, Tudor I Oprea, Anna Karlsson, Francois Boulay, Marie-Josephe Rabiet, Claes Dahlgren
Biochimica et biophysica acta - 2013 -
The Human Neutrophil Subsets Defined by the Presence or Absence of OLFM4 Both Transmigrate into Tissue In Vivo and Give Rise to Distinct NETs In
Vitro.
Amanda Welin, Firoozeh Amirbeagi, Karin Christenson, Lena Björkman, Halla Björnsdottir, Huamei Forsman, Claes Dahlgren, Anna Karlsson, Johan Bylund
PloS one - 2013 -
Reactivation of Desensitized Formyl Peptide Receptors by Platelet Activating Factor: A Novel Receptor Cross Talk Mechanism Regulating Neutrophil Superoxide Anion
Production
Huamei Forsman, Karin Önnheim, Emil Andréasson, Karin Christenson, Anna Karlsson, Johan Bylund, Claes Dahlgren
Plos One - 2013 -
A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR
1.
Hülya Çevik Aras, Christina Kalderén, Annika Jenmalm Jensen, Tudor I Oprea, Claes Dahlgren, Huamei Forsman
Biochemical pharmacology - 2012 -
Receptor-Dependent and -Independent Immunomodulatory Effects of Phenol-Soluble Modulin Peptides from Staphylococcus aureus on Human Neutrophils Are Abrogated through Peptide Inactivation by Reactive Oxygen
Species
Huamei Forsman, Karin Christenson, Johan Bylund, Claes Dahlgren
Infection and Immunity - 2012 -
Structural Characterization and Inhibitory Profile of Formyl Peptide Receptor 2 Selective Peptides Descending from a PIP2-Binding Domain of
Gelsolin.
Huamei Forsman, Emil Andréasson, Jennie Karlsson, Francois Boulay, Marie-Josèphe Rabiet, Claes Dahlgren
Journal of immunology (Baltimore, Md. : 1950) - 2012 -
Response to Letter by X. Li, Q. Y. Zhou, F. L. Yuan. Galectin-3 as a novel therapeutic target in rheumatoid arthritis: comment on the article by Forsman et
al
Huamei Forsman, Ulrika Islander, Anna Karlsson
Arthritis and Rheumatism - 2011 -
Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the
intestine.
Amlan Biswas, Jeanette Wilmanski, Huamei Forsman, Tomas Hrncir, Liming Hao, Helena Tlaskalova-Hogenova, Koichi S Kobayashi
European journal of immunology - 2011 -
WHAT FORMYL PEPTIDE RECEPTORS, IF ANY, ARE TRIGGERED BY COMPOUND 43 AND LIPOXIN A(4)
?
Huamei Forsman, Karin Önnheim, Emil Andreasson, Claes Dahlgren
Scandinavian journal of immunology - 2011 -
Galectin-3 aggravates joint inflammation and destruction in antigen-induced
arthritis.
Huamei Forsman, Ulrika Islander, Emil Andréasson, Annica Andersson, Karin Önnheim, Alexandra Karlström, Karin Sävman, Mattias Magnusson, Kelly Brown, Anna Karlsson
Arthritis and rheumatism - 2011 -
Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound
library.
Huamei Forsman, Christina Kalderén, Anna Nordin, Erik Nordling, Annika Jernmalm Jensen, Claes Dahlgren
Biochemical pharmacology - 2011 -
The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor
1.
Fredrik Bergh Thorén, Jennie Karlsson, Claes Dahlgren, Huamei Forsman
Biochemical pharmacology - 2010 -
A methodological approach to studies of desensitization of the formyl peptide receptor: Role of the read out system, reactive oxygen species and the specific agonist used to trigger
neutrophils.
Jennie Karlsson, Johan Bylund, Charlotta Movitz, Lena Björkman, Huamei Forsman, Claes Dahlgren
Journal of immunological methods - 2010 -
The FPR2-induced rise in cytosolic calcium in human neutrophils relies on an emptying of intracellular calcium stores and is inhibited by a gelsolin-derived PIP2-binding
peptide.
Huamei Forsman, Claes Dahlgren
BMC cell biology - 2010 -
The host defense peptide LL-37 selectively permeabilizes apoptotic
leukocytes.
Åse Björstad, Galia Askarieh, Kelly Brown, Karin Christenson, Huamei Forsman, Karin Önnheim, Hsin-Ni Li, Susann Teneberg, Olaf Maier, Dick Hoekstra, Claes Dahlgren, Donald J Davidson, Johan Bylund
Antimicrobial agents and chemotherapy - 2009 -
Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide
receptors.
Huamei Forsman, Claes Dahlgren
Scandinavian journal of immunology - 2009 -
The FPR2-specific ligand MMK-1 activates the neutrophil NADPH-oxidase, but triggers no unique pathway for opening of plasma membrane calcium
channels.
Jennie Karlsson, Anna-Lena Stenfeldt, Marie-Josèphe Rabiet, Johan Bylund, Huamei Forsman, Claes Dahlgren
Cell calcium - 2009 -
The beta-galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the
agonist
Huamei Forsman, E. Salomonsson, Karin Önnheim, Jennie Karlsson, Åse Björstad, H. Leffler, Johan Bylund, Anna Karlsson, Claes Dahlgren
Glycobiology - 2008 -
Tumour necrosis factor (TNF)-alpha primes murine neutrophils when triggered via formyl peptide receptor-related sequence 2, the murine orthologue of human formyl peptide receptor-like 1, through a process involving the type I TNF receptor and subcellular granule
mobilization
Karin Önnheim, Johan Bylund, F. Boulay, Claes Dahlgren, Huamei Forsman
Immunology - 2008 -
Changes in the ratio between FPR and FPRL1 triggered superoxide production in human neutrophils-a tool in analysing receptor specific
events
Huamei Fu, Jennie Karlsson, Lena Björkman, Anna-Lena Stenfeldt, Anna Karlsson, Johan Bylund, Claes Dahlgren
Journal of Immunological Methods - 2008 -
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor
like-1
Lena Björkman, Jennie Karlsson, Anna Karlsson, M. J. Rabiet, F. Boulay, Huamei Fu, Johan Bylund, Claes Dahlgren
Journal of Leukocyte Biology - 2008 -
Antimicrobial host defence peptides of human neutrophils – roles in innate
immunity
Åse Björstad, Kelly Brown, Huamei Fu, Claes Dahlgren, Anna Karlsson, Johan Bylund
Anti-Infective Agents in Medicinal Chemistry - 2008 -
The non-steroidal anti-inflammatory drug piroxicam blocks ligand binding to the formyl peptide receptor but not the formyl peptide receptor like
1
Anna-Lena Stenfeldt, Jennie Karlsson, Christine Wennerås, Johan Bylund, Huamei Fu, Claes Dahlgren
Biochem Pharmacol - 2007 -
Cyclosporin H, Boc-MLF and Boc-FLFLF are Antagonists that Preferentially Inhibit Activity Triggered Through the Formyl Peptide
Receptor
Anna-Lena Stenfeldt, Jennie Karlsson, Christine Wennerås, Johan Bylund, Huamei Fu, Claes Dahlgren
Inflammation - 2007 -
A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor
Family.
Lars Bellner, Jennie Karlsson, Huamei Fu, François Boulay, Claes Dahlgren, Kristina Eriksson, Anna Karlsson
Journal of immunology (Baltimore, Md. : 1950) - 2007 -
Ligand recognition and activation of formyl peptide receptors in
neutrophils
Huamei Fu, Jenny Karlsson, Johan Bylund, Charlotta Movitz, Anna Karlsson, Claes Dahlgren
J Leukoc Biol - 2006 -
The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptide receptor like 1 is blocked. A receptor switch with implications for signal transduction studies with inhibitors and receptor
antagonists
Jennie Karlsson, Huamei Fu, F. Boulay, Johan Bylund, Claes Dahlgren
Biochemical pharmacology - 2006 -
Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family
receptors
Jennie Karlsson, Huamei Fu, F. Boulay, Claes Dahlgren, Kristoffer Hellstrand, Charlotta Movitz
Journal of leukocyte biology - 2005 -
Interleukin-8-derived peptide has antibacterial
activity
Åse Björstad, Huamei Fu, Anna Karlsson, Claes Dahlgren, Johan Bylund
Antimicrobial agents and chemotherapy - 2005 -
Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed
neutrophils
Johan Bylund, Sara Pellmé, Huamei Fu, Ulf-Henrik Mellqvist, Kristoffer Hellstrand, Anna Karlsson, Claes Dahlgren
BMC cell biology - 2004 -
Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the
cytoskeleton
Huamei Fu
2004 -
The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding
peptide
Huamei Fu, Lena Björkman, P. Janmey, Anna Karlsson, Jennie Karlsson, Charlotta Movitz, Claes Dahlgren
BMC cell biology - 2004 -
A bactericidal cecropin-A peptide with a stabilized alpha-helical structure possess an increased killing capacity but no proinflammatory
activity
Huamei Fu, Åse Björstad, Claes Dahlgren, Johan Bylund
Inflammation - 2004 -
The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for
interleukin-8
Huamei Fu, Johan Bylund, Anna Karlsson, Sara Pellmé, Claes Dahlgren
Immunology - 2004 -
Outer membrane protein A deficient Escherichia coli activates neutrophils to produce superoxide and shows increased susceptibility to antibacterial
peptides
Huamei Fu, A. A. Belaaouaj, Claes Dahlgren, Johan Bylund
Microbes Infect - 2003 -
Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial
chemotherapy
Huamei Fu, Claes Dahlgren, Johan Bylund
Antimicrob Agents Chemother - 2003