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Jan Boren
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Avd för molekylär och klinisk-
Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic
Analysis
Elias Björnson, Martin Adiels, Marja Riitta Taskinen, Stephen Burgess, M. John Chapman, Chris J. Packard, Jan Borén
Journal of the American College of Cardiology - 2024 -
Role of Perilipins in Oxidative Stress-Implications for Cardiovascular
Disease
Mathieu Cinato, Linda Andersson, Azra Miljanovic, Marion Laudette, Oksana Kunduzova, Jan Borén, Malin Levin
ANTIOXIDANTS - 2024 -
ANGPTL3 Downregulation Increases Intracellular Lipids by Reducing Energy
Utilization.
Grazia Pennisi, Samantha Maurotti, Ester Ciociola, Jamialahmadi Oveis, Giorgio Bertolazzi, Angela Mirarchi, Per-Olof Bergh, Francesca Scionti, Rosellina Margherita Mancina, Rocco Spagnuolo, Claudio Tripodo, Jan Borén, Salvatore Petta, Stefano Romeo
Arteriosclerosis, thrombosis, and vascular biology - 2024 -
Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin
therapy
Marja-Riitta Taskinen, Niina Matikainen, Elias Björnson, Sanni Soderlund, Jussi Inkeri, Antti Hakkarainen, Helka Parviainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Borén
DIABETOLOGIA - 2023 -
Cardiomyocytes, sphingolipids and cardio
myotoxicity
Malin Levin, Linda Andersson, Jan Borén
Current Opinion in Lipidology - 2023 -
High levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific
manner
J. M. Assini, J. R. Clark, A. Youssef, C. C. Xing, A. M. Doerfler, S. H. Park, L. Saxena, A. B. Yaseen, Jan Borén, R. Gros, G. Bao, W. R. Lagor, M. B. Boffa, M. L. Koschinsky
Atherosclerosis - 2023 -
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic
activators
H. Yang, X. Y. Li, H. Jin, H. Turkez, G. Ozturk, H. L. Doganay, C. Zhang, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Free Radical Biology and Medicine - 2023 -
Replacing Foods with a High-Glycemic Index and High in Saturated Fat by Alternatives with a Low Glycemic Index and Low Saturated Fat Reduces Hepatic Fat, Even in Isocaloric and Macronutrient Matched
Conditions
J. Basset-Sagarminaga, K. H. M. Roumans, B. Havekes, R. P. Mensink, H. P. F. Peters, P. L. Zock, R. de Mutsert, Jan Borén, L. Lindeboom, P. Schrauwen, V. B. Schrauwen-Hinderling
Nutrients - 2023 -
Serendipitous Identification of a Covalent Activator of Liver Pyruvate
Kinase
Umberto Battisti, Chunxia Gao, Oscar Nilsson, Fady Akladios, A. Lulla, A. Bogucka, Amalyn Nain-Perez, Liliana Håversen, W. Kim, Jan Borén, M. Hyvonen, M. Uhlen, A. Mardinoglu, Morten Grötli
Chembiochem - 2023 -
Cerebrospinal fluid sulfatide isoforms lack diagnostic utility in separating progressive from relapsing-remitting multiple
sclerosis.
Lenka Novakova, Marcus Henricsson, Elias Björnson, Markus Axelsson, Jan Borén, Igal Rosenstein, Jan Lycke, Susanna Cardell, Maria K. Blomqvist
Multiple sclerosis and related disorders - 2023 -
Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart
function.
Marion Laudette, Malin Lindbom, Muhammad Arif, Mathieu Cinato, Mario Ruiz, Stephen Doran, Azra Miljanovic, Mikael Rutberg, Linda Andersson, Martina Klevstig, Marcus Henricsson, Per-Olof Bergh, Entela Bollano, Nay Aung, J. Gustav Smith, Marc Pilon, Tuulia Hyötyläinen, Matej Orešič, Rosie Perkins, Adil Mardinoglu, Malin Levin, Jan Borén
Cardiovascular research - 2023 -
Twenty Years of Cardiovascular Complications and Risk Factors in Patients With Type 2 Diabetes: A Nationwide Swedish Cohort
Study
N. Sattar, J. McMurray, Jan Borén, Araz Rawshani, Elmir Omerovic, Niklas Bergh, Janita Halminen, Kristofer Skoglund, B. Eliasson, H. C. Gerstein, D. K. McGuire, D. Bhatt, Aidin Rawshani
Circulation - 2023 -
The acute effect of different NAD plus precursors included in the combined metabolic
activators
X. Y. Li, H. Yang, H. Jin, H. Turkez, G. Ozturk, H. L. Doganay, C. Zhang, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Free Radical Biology and Medicine - 2023 -
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate
Kinase
Umberto Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, W. Kim, M. Uhlen, Jan Borén, A. Mardinoglu, Morten Grötli
Pharmaceuticals - 2023 -
Tuning liver pyruvate kinase activity up or down with a new class of allosteric
modulators
Amalyn Nain-Perez, Oscar Nilsson, A. Lulla, Liliana Håversen, P. Brear, Sara Liljenberg, M. Hyvonen, Jan Borén, Morten Grötli
European Journal of Medicinal Chemistry - 2023 -
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte
contractility
Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Christina Drevinge, Marion Laudette, Entela Bollano, Marcus Henricsson, Johan Tolö, Marco Bauzá-Thorbrügge, Max Levin, Malin Lindbom, M. Arif, P. Pacher, Linda Andersson, Charlotta S Olofsson, Jan Borén, Malin Levin
Life Science Alliance - 2023 -
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II
trial
B. Yulug, O. Altay, X. Y. Li, L. Hanoglu, S. Cankaya, S. Lam, H. A. Velioglu, H. Yang, E. Coskun, E. Idil, R. Nogaylar, A. Ozsimsek, C. Bayram, I. Bolat, S. Oner, O. O. Tozlu, M. E. Arslan, A. Hacimuftuoglu, S. Yildirim, M. Arif, S. Shoaie, C. Zhang, J. Nielsen, H. Turkez, Jan Borén, M. Uhlen, A. Mardinoglu
Translational Neurodegeneration - 2023 -
Cardiac arrhythmias and conduction abnormalities in patients with type 2
diabetes
Araz Rawshani, D. K. McGuire, Elmir Omerovic, N. Sattar, J. J. V. McMurray, Ulf Smith, Björn Redfors, Lennart Bergfeldt, Björn Eliasson, Jan Borén, D. L. Bhatt, Göran Bergström, Aidin Rawshani
Scientific Reports - 2023 -
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative
diseases
H. Turkez, O. Altay, S. Yildirim, X. Y. Li, H. Yang, C. Bayram, I. Bolat, S. Oner, O. O. Tozlu, M. E. Arslan, M. Arif, B. Yulug, L. Hanoglu, S. Cankaya, S. Lam, H. A. Velioglu, E. Coskun, E. Idil, R. Nogaylar, A. Ozsimsek, A. Hacimuftuoglu, S. Shoaie, C. Zhang, J. Nielsen, Jan Borén, M. Uhlen, A. Mardinoglu
Life Sciences - 2023 -
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate
Kinase
Umberto Battisti, Chunxia Gao, Fady Akladios, W. Kim, H. Yang, C. Bayram, I. Bolat, M. Kiliclioglu, N. Yuksel, O. O. Tozlu, C. Zhang, J. Sebhaoui, S. Iqbal, S. Shoaie, A. Hacimuftuoglu, S. Yildirim, H. Turkez, M. Uhlen, Jan Borén, A. Mardinoglu, Morten Grötli
Nutrients - 2023 -
Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank
study
Elias Björnson, Martin Adiels, M. R. Taskinen, S. Burgess, Aidin Rawshani, Jan Borén, C. J. Packard
European Heart Journal - 2023 -
Role of endogenous incretins in the regulation of postprandial lipoprotein
metabolism
M. R. Taskinen, N. Matikainen, Elias Björnson, S. Soderlund, M. Ainola, A. Hakkarainen, N. Lundbom, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, B. Hartmann, C. F. Deacon, J. J. Holst, C. J. Packard, Jan Borén
European Journal of Endocrinology - 2022 -
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function
mutations
M. R. Taskinen, Elias Björnson, N. Matikainen, S. Soderlund, J. Ramo, M. M. Ainola, A. Hakkarainen, C. Sihlbom, A. Thorsell, Linda Andersson, Per-Olof Bergh, Marcus Henricsson, Stefano Romeo, Martin Adiels, S. Ripatti, M. Laakso, C. J. Packard, Jan Borén
Jci Insight - 2022 -
Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2
Diabetes
Araz Rawshani, N. Sattar, D. K. McGuire, Oskar Wallström, Ulf Smith, Jan Borén, Göran Bergström, Elmir Omerovic, Annika Rosengren, Björn Eliasson, D. L. Bhatt, Aidin Rawshani
Circulation - 2022 -
pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic Binding of Low-Density Lipoproteins to Human Coronary
Arteries
Lars Glise, Mikael Rutberg, Liliana Håversen, Malin Levin, Max Levin, Anders Jeppsson, Jan Borén, Per Fogelstrand
Arteriosclerosis Thrombosis and Vascular Biology - 2022 -
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and
embryogenesis.
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon
Nature communications - 2022 -
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning
approach
X. Li, K. Shong, W. Kim, M. Yuan, H. Yang, Y. Sato, H. Kume, S. Ogawa, H. Turkez, S. Shoaie, Jan Borén, J. Nielsen, M. Uhlen, C. Zhang, A. Mardinoglu
Ebiomedicine - 2022 -
Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic
Steatosis
M. Zeybel, M. Arif, X. Li, O. Altay, H. Yang, M. Shi, M. Akyildiz, B. Saglam, M. G. Gonenli, B. Yigit, B. Ulukan, D. Ural, S. Shoaie, H. Turkez, J. Nielsen, C. Zhang, M. Uhlén, Jan Borén, A. Mardinoglu
Advanced Science - 2022 -
Discovery of therapeutic agents targeting PKLR for NAFLD using drug
repositioning
C. Zhang, M. N. Shi, W. Kim, M. Arif, Martina Klevstig, X. Y. Li, H. Yang, C. Bayram, I. Bolat, O. O. Tozlu, J. Sebhaoui, S. Iqbal, Y. J. Wei, X. J. Shi, J. Nielsen, H. Turkez, M. Uhlen, Jan Borén, A. Mardinoglu, A. Haamuftuoglu, S. Yildtrim
eBioMedicine - 2022 -
The spoils of war and the long-term spoiling of health conditions of entire
nations.
Eliano P Navarese, Klaudyna Grzelakowska, Francesco Mangini, Jacek Kubica, Maciej Banach, Marianne Benn, Christoph J Binder, Jan Borén, Alberico Catapano, Florian Kronenberg, Ziad Mallat, Philippe Moulin, Katariina Öörni, Kausik K Ray, Jeanine E Roeters van Lennep, Stefano Romeo, Lale Tokgozoglu, Arnold von Eckardstein, Alberto Zambon, Paolo Raggi
Atherosclerosis - 2022 -
Metabolism of triglyceride-rich lipoproteins in health and
dyslipidaemia
Jan Borén, M. R. Taskinen, Elias Björnson, C. J. Packard
Nature Reviews Cardiology - 2022 -
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate
kinase
Amalyn Nain-Perez, Anders Füchtbauer, Liliana Håversen, A. Lulla, Chunxia Gao, Josipa Matic, Letitia Monjas, Alexandra Rodriguez, P. Brear, W. Kim, M. Hyvonen, Jan Borén, A. Mardinoglu, M. Uhlen, Morten Grötli
European Journal of Medicinal Chemistry - 2022 -
The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation
analyses
I. Drake, Emanuel Fryk, Lena Strindberg, Annika Lundqvist, Anders H. Rosengren, L. Groop, E. Ahlqvist, Jan Borén, M. Orho-Melander, Per-Anders Jansson
Diabetologia - 2022 -
Effects of pnpla3 i148m on hepatic lipid and very low-density lipoprotein metabolism in
humans.
Jan Borén, Martin Adiels, Elias Björnson, Niina Matikainen, Sanni Söderlund, Joel Rämö, Marcus Ståhlman, Pietari Ripatti, Samuli Ripatti, Aarno Palotie, Rosellina Margherita Mancina, Mari Ainola, Antti Hakkarainen, Stefano Romeo, Chris J Packard, Marja-Riitta Taskinen
Journal of internal medicine - 2022 -
Modified lipid metabolism and cytosolic phospholipase A2 activation in mesangial cells under pro-inflammatory
conditions
Roberto Boi, Kerstin Ebefors, Marcus Henricsson, Jan Borén, Jenny Nyström
Scientific Reports - 2022 -
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor
trafficking.
Linda Andersson, Mathieu Cinato, Ismena Mardani, Azra Miljanovic, Arif Mohammed, Ara Koh, Malin Lindbom, Marion Laudette, Entela Bollano, Elmir Omerovic, Martina Klevstig, Marcus Henricsson, Per Fogelstrand, Karl Swärd, Matias Ekstrand, Max Levin, Johannes Wikström, Stephen Doran, Tuulia Hyötyläinen, Lisanna Sinisalu, Matej Oresic, Åsa Tivesten, Martin Adiels, Martin O Bergo, Richard Proia, Adil Mardinoglu, Anders Jeppsson, Jan Borén, Malin Levin
European heart journal - 2021 -
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat
Diet
H. Yang, J. Mayneris-Perxachs, N. Boque, J. M. del Bas, L. Arola, M. Yuan, H. Tuerkez, M. Uhlen, Jan Borén, C. Zhang, A. Mardinoglu, A. Caimari
Biomedicines - 2021 -
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease
patients
M. Zeybel, O. Altay, M. Arif, X. Y. Li, H. Yang, C. Fredolini, M. Akyildiz, B. Saglam, M. G. Gonenli, D. Ural, W. Kim, J. M. Schwenk, C. Zhang, S. Shoaie, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Molecular Systems Biology - 2021 -
Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis
Society
H. N. Ginsberg, C. J. Packard, M. J. Chapman, Jan Borén, C. A. Aguilar-Salinas, M. Averna, B. A. Ference, D. Gaudet, R. A. Hegele, S. Kersten, G. F. Lewis, A. H. Lichtenstein, P. Moulin, B. G. Nordestgaard, A. T. Remaley, B. Staels, E. S. G. Stroes, M. R. Taskinen, L. S. Tokgozoglu, A. Tybjaerg-Hansen, J. K. Stock, A. L. Catapano
European Heart Journal - 2021 -
Testosterone reduces metabolic brown fat activity in male
mice
Marta Lantero Rodriguez, M. Schilperoort, Inger Johansson, Elin Svedlund Eriksson, Vilborg Palsdottir, J. Kroon, Marcus Henricsson, S. Kooijman, Mia Ericson, Jan Borén, Claes Ohlsson, John-Olov Jansson, Malin Levin, P. C. N. Rensen, Åsa Tivesten
Journal of Endocrinology - 2021 -
Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver
disease
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, M. Amrutkar, E. Scandalis, S. L. Booten, Marcus Ståhlman, Jan Borén, Hanns-Ulrich Marschall, M. Aghajan, Margit Mahlapuu
FASEB Journal - 2021 -
Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve
stenosis
D. Kocyigit, F. Zimetti, K. M. Gurses, I. Zanotti, C. Marchi, M. Ståhlman, Jan Borén, H. Canpinar, M. F. T. Soyal, D. Guc, T. Hazirolan, N. Ozer, L. Tokgozoglu
Atherosclerosis Plus - 2021 -
A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological
traits
Ranjan Devkota, Delaney Kaper, Rakesh Bodhicharla, Marcus Henricsson, Jan Borén, Marc Pilon
Genetics - 2021 -
Intussusceptive angiogenesis in human metastatic malignant
melanoma.
Ankur Pandita, Matias Ekstrand, Sara Bjursten, Zhiyuan Zhao, Per Fogelstrand, Kristell Le Gal, Lars Ny, Martin O Bergo, Joakim Karlsson, Jonas A Nilsson, Levent Akyürek, Malin Levin, Jan Borén, Andrew J Ewald, Keith E Mostov, Max Levin
The American Journal of Pathology - 2021 -
Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple
myeloma
Lenka Besse, Andrej Besse, Sara C. Stolze, Amin Sobh, Esther A. Zaal, Alwin J.Van Der Ham, Mario Ruiz, Santosh Phuyal, Lorina Buchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J. Thomas Hannich, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Christopher D. Vulpe, Herman S. Overkleeft, Christoph Driessen
Cancer Research - 2021 -
Stratification of patients with clear cell renal cell carcinoma to facilitate drug
repositioning
X. Li, W. Kim, K. Juszczak, M. Arif, Y. Sato, H. Kume, S. Ogawa, H. Turkez, Jan Borén, J. Nielsen, M. Uhlen, C. Zhang, A. Mardinoglu
iScience - 2021 -
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate
COVID-19
O. Altay, M. Arif, X. Li, H. Yang, M. Aydın, G. Alkurt, W. Kim, D. Akyol, C. Zhang, G. Dinler-Doganay, H. Turkez, S. Shoaie, J. Nielsen, Jan Borén, O. Olmuscelik, L. Doganay, M. Uhlén, A. Mardinoglu
Advanced Science - 2021 -
Effects of Evolocumab on the Postprandial Kinetics of Apo (Apolipoprotein) B100- and B48-Containing Lipoproteins in Subjects With Type 2
Diabetes.
Marja-Riitta Taskinen, Elias Björnson, Juhani Kahri, Sanni Söderlund, Niina Matikainen, Kimmo Porthan, Mari Ainola, Antti Hakkarainen, Nina Lundbom, Valentina Fermanelli, Johannes Fuchs, Annika Thorsell, Florian Kronenberg, Linda Andersson, Martin Adiels, Chris J Packard, Jan Borén
Arteriosclerosis, thrombosis, and vascular biology - 2021 -
Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing
AdipoR2
Mario Ruiz, Marcus Henricsson, Jan Borén, Marc Pilon
Lipids in Health and Disease - 2021 -
Multi-omics approaches for revealing the complexity of cardiovascular
disease
S. Doran, M. Arif, S. Lam, A. Bayraktar, H. Turkez, M. Uhlen, Jan Borén, A. Mardinoglu
Briefings in bioinformatics - 2021 -
Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte
lipotoxicity
Marion Laudette, Y. Sainte-Marie, G. Cousin, D. Bergonnier, I. Belhabib, S. Brun, K. Formoso, L. Laib, F. Tortosa, C. Bergoglio, B. Marcheix, Jan Borén, O. Lairez, J. Fauconnier, A. Lucas, J. Mialet-Perez, C. Moro, F. Lezoualc'h
Cell death & disease - 2021 -
Sacubitril/valsartan decreases mortality in the rat model of the isoprenaline-induced takotsubo-like
syndrome
Anwar Ali Gasim Elsied, Björn Redfors, Jessica Alkhoury, Jonatan Oras, Marcus Henricsson, Jan Borén, Elias Björnson, Aaron Shekka Espinosa, Malin Levin, Li-Ming Gan, Elmir Omerovic
ESC Heart Failure - 2021 -
APRIL limits atherosclerosis by binding to heparan sulfate
proteoglycans
D. Tsiantoulas, M. Eslami, G. Obermayer, M. Clement, D. Smeets, F. J. Mayer, M. G. Kiss, L. Enders, J. Weisser, L. Goderle, J. Lambert, F. Frommlet, A. Mueller, T. Hendrikx, M. Ozsvar-Kozma, F. Porsch, L. Willen, T. Afonyushkin, J. E. Murphy, Per Fogelstrand, O. Donze, G. Pasterkamp, M. Hoke, S. Kubicek, H. F. Jorgensen, N. Danchin, T. Simon, H. Scharnagl, W. Marz, Jan Borén, H. Hess, Z. Mallat, P. Schneider, C. J. Binder
Nature - 2021 -
Early rise in brain damage markers and high ICOS expression in CD4+and CD8+T cells during checkpoint inhibitor-induced
encephalomyelitis
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, C. Frojd, Lars Ny, C. Jensen, T. Ullerstam, Henrik Jespersen, Jan Borén, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin
Journal for Immunotherapy of Cancer - 2021 -
STE20-Type Protein Kinase MST4 Controls NAFLD Progression by Regulating Lipid Droplet Dynamics and Metabolic Stress in
Hepatocytes
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Ståhlman, Nagaraj M. Kulkarni, Jan Borén, Hanns-Ulrich Marschall, M. Bluher, Margit Mahlapuu
Hepatology Communications - 2021 -
Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE(-/-)
mice
P. Duner, I. Y. Mattisson, Per Fogelstrand, Lars Glise, S. Ruiz, C. Farina, Jan Borén, J. Nilsson, E. Bengtsson
Scientific Reports - 2021 -
Relationship between de novo lipogenesis and serum sex hormone binding globulin in
humans
Pihg Simons, O. Valkenburg, I. Telgenkamp, K. M. van der Waaij, D. M. de Groot, P. Veeraiah, J. A. P. Bons, M. R. Taskinen, Jan Borén, P. Schrauwen, J. H. W. Rutten, D. Cassiman, C. G. Schalkwijk, C. D. A. Stehouwer, V. B. Schrauwen-Hinderling, L. Hodson, Mcgj Brouwers
Clinical Endocrinology - 2021 -
Effects of liraglutide on the metabolism of triglyceride-rich lipoproteins in type 2
diabetes
M. R. Taskinen, Elias Björnson, N. Matikainen, S. Soderlund, K. H. Pietilainen, M. Ainola, A. Hakkarainen, N. Lundbom, Johannes Fuchs, Annika Thorsell, Linda Andersson, Martin Adiels, C. J. Packard, Jan Borén
Diabetes Obesity & Metabolism - 2021 -
The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated
fats
Ranjan Devkota, Marcus Henricsson, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty
acids
Mario Ruiz, H. Palmgren, Marcus Henricsson, Ranjan Devkota, H. Jaiswal, M. Maresca, M. Bohlooly-Y, X. R. Peng, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Association of dietary and gut microbiota-related metabolites with calcific aortic
stenosis
K. Duygu, L. Tokgozoglu, K. M. Gurses, Marcus Ståhlman, Jan Borén, M. F. T. Soyal, H. Canpinar, D. Guc, A. S. Ayhan, T. Hazirolan, N. Ozer
Acta Cardiologica - 2021 -
Systems biology based drug repositioning for development of cancer
therapy
B. Turanli, O. Altay, Jan Borén, H. Turkez, J. Nielsen, M. Uhlen, K. Y. Arga, A. Mardinoglu
Seminars in Cancer Biology - 2021 -
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic liver
disease
H. Yang, M. Arif, M. Yuan, X. Y. Li, K. Shong, H. Turkez, J. Nielsen, M. Uhlen, Jan Borén, C. Zhang, A. Mardinoglu
Iscience - 2021 -
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial
infarction
M. Arif, Martina Klevstig, R. Benfeitas, S. Doran, H. Turkez, M. Uhlen, M. Clausen, J. Wikstrom, D. Etal, C. Zhang, Malin Levin, A. Mardinoglu, Jan Borén
Elife - 2021 -
Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in
Humans
J. R. Bosley, Elias Björnson, C. Zhang, H. Turkez, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Frontiers in Pharmacology - 2021 -
Addressing the heterogeneity in liver diseases using biological
networks
S. Lam, S. Doran, H. H. Yuksel, O. Altay, H. Turkez, J. Nielsen, Jan Borén, M. Uhlen, A. Mardinoglu
Briefings in Bioinformatics - 2021 -
Discovery of Functional Alternatively Spliced PKM Transcripts in Human
Cancers
X. Y. Li, W. Kim, M. Arif, Chunxia Gao, A. Hober, D. Kotol, L. Strandberg, B. Forsstrom, A. Sivertsson, P. Oksvold, H. Turkez, Morten Grötli, Y. Sato, H. Kume, S. Ogawa, Jan Borén, J. Nielsen, M. Uhlen, C. Zhang, A. Mardinoglu
Cancers - 2021 -
Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and
EFLM
M. R. Langlois, Bø G. Nordestgaard, A. Langsted, M. J. Chapman, K. M. Aakre, H. Baum, Jan Borén, E. Bruckert, A. Catapano, C. Cobbaert, P. Collinson, O. S. Descamps, C. J. Duff, A. Von Eckardstein, A. Hammerer-Lercher, P. R. Kamstrup, G. Kolovou, F. Kronenberg, S. Mora, K. Pulkki, A. T. Remaley, N. Rifai, E. Ros, S. Stankovic, A. Stavljenic-Rukavina, G. Sypniewska, G. F. Watts, Olov Wiklund, P. Laitinen
Clinical Chemistry and Laboratory Medicine - 2020 -
Multimodal MALDI Imaging Mass Spectrometry Reveals Spatially Correlated Lipid and Protein Changes in Mouse Heart with Acute Myocardial
Infarction
Ibrahim Kaya, Sanna Sämfors, Malin Levin, Jan Borén, John S. Fletcher
Journal of the American Society for Mass Spectrometry - 2020 -
Classification of clear cell renal cell carcinoma based on PKM alternative
splicing
X. Y. Li, B. Turanli, K. Juszczak, W. Kim, M. Arif, Y. Sato, S. Ogawa, H. Turkez, J. Nielsen, Jan Borén, M. Uhlen, C. Zhang, A. Mardinoglu
Heliyon - 2020 -
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR
proteins
Kiran Busayavalasa, Mario Ruiz, Ranjan Devkota, Marcus Ståhlman, Rakesh Bodhicharla, Emma Svensk, N. O. Hermansson, Jan Borén, Marc Pilon
Plos Genetics - 2020 -
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug
Repositioning
E. Mohammadi, R. Benfeitas, H. Turkez, Jan Borén, M. Uhlen, A. Mardinoglu
Cancers - 2020 -
Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus
statement
R. A. Hegele, Jan Borén, H. N. Ginsberg, M. Arca, M. Averna, C. J. Binder, L. Calabresi, M. J. Chapman, M. Cuchel, A. von Eckardstein, R. Frikke-Schmidt, D. Gaudet, G. K. Hovingh, F. Kronenberg, D. Lutjohann, K. G. Parhofer, F. J. Raal, K. K. Ray, A. T. Remaley, J. K. Stock, E. S. Stroes, L. Tokgozoglu, A. L. Catapano
Lancet Diabetes & Endocrinology - 2020 -
A 7-day high-fat, high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal
muscle
K. L. Whytock, S. A. Parry, M. C. Turner, R. M. Woods, L. J. James, R. A. Ferguson, Marcus Ståhlman, Jan Borén, J. A. Strauss, M. Cocks, A. J. M. Wagenmakers, C. J. Hulston, S. O. Shepherd
Journal of Physiology-London - 2020 -
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver
disease.
Cheng Zhang, Elias Björnson, Muhammad Arif, Abdellah Tebani, Alen Lovric, Rui Benfeitas, Mehmet Ozcan, Kajetan Juszczak, Woonghee Kim, Jung Tae Kim, Gholamreza Bidkhori, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Hasan Turkez, Marja-Riitta Taskinen, Jim Bosley, Hanns-Ulrich Marschall, Jens Nielsen, Mathias Uhlén, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2020 -
Lack of RAC1 in macrophages protects against
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O. Bergö, Levent Akyürek
PLoS One - 2020 -
Causes and Consequences of
Hypertriglyceridemia
C. J. Packard, Jan Borén, M. R. Taskinen
Frontiers in Endocrinology - 2020 -
Impact of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab on the postprandial responses of triglyceride-rich lipoproteins in type II diabetic
subjects
M. R. Taskinen, Elias Björnson, Linda Andersson, J. Kahri, K. Porthan, N. Matikainen, S. Soderlund, K. Pietilainen, A. Hakkarainen, N. Lundbom, R. Nilsson, Marcus Ståhlman, Martin Adiels, P. Parini, C. Packard, Jan Borén
Journal of Clinical Lipidology - 2020 -
Effects of TM6SF2 E167K on hepatic lipid and very low-density lipoprotein metabolism in
humans.
Jan Borén, Martin Adiels, Elias Björnson, Nina Matikainen, Sanni Söderlund, Joel T Rämo, Marcus Ståhlman, Puetaru Ripatti, Samuli Ripatti, Aarno Palotie, Rosellina Margherita Mancina, Antti Hakkarainen, Stefano Romeo, Chris j Packard, Marja-Riitta Taskinen
JCI insight - 2020 -
Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney
disease.
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W Howell, Margit Mahlapuu
JCI insight - 2020 -
Lipid profiling of human diabetic myocardium reveals differences in triglyceride fatty acyl chain length and degree of
saturation.
Elias Björnson, Ylva Östlund, Marcus Ståhlman, Martin Adiels, Elmir Omerovic, Anders Jeppsson, Jan Borén, Malin Levin
International journal of cardiology - 2020 -
Suppressed Vascular Leakage and Myocardial Edema Improve Outcome From Myocardial
Infarction.
Xiujuan Li, Björn Redfors, Miguel Sáinz-Jaspeado, Shujing Shi, Pernilla Martinsson, Narendra Padhan, Margareta Scharin Täng, Jan Borén, Malin Levin, Lena Claesson-Welsh
Frontiers in physiology - 2020 -
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine
Approach
M. Ozcan, O. Altay, S. Lam, H. Turkez, Y. Aksoy, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Advanced Biosystems - 2020 -
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus
Panel.
Jan Borén, M John Chapman, Ronald M Krauss, Chris J Packard, Jacob F Bentzon, Christoph J Binder, Mat J Daemen, Linda L Demer, Robert A Hegele, Stephen J Nicholls, Borge G Nordenstgaard, Gerald F Watts, Eric Bruckert, Sergio Fazio, Brian A Ference, Ian Graham, Jay D Horton, Ulf Landmesser, Ulrich Laufs, Luis Masana, Gerard Pasterkamp, Frederick J Raal, Kausik K Ray, Heribert Schunkert, Marja-Riitta Taskinen, Bart van de Sluis, Olov Wiklund, Lale Tokgozoglu, Alberico L Catapano, Henry N Ginsberg
European heart journal - 2020 -
The Roles of ApoC-III on the Metabolism of Triglyceride-Rich Lipoproteins in
Humans
Jan Borén, C. J. Packard, M. R. Taskinen
Frontiers in Endocrinology - 2020 -
Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative
Diseases
D. Rosario, Jan Borén, M. Uhlen, G. Proctor, D. Aarsland, A. Mardinoglu, S. Shoaie
Frontiers in Neuroscience - 2020 -
A systems biology approach for studying neurodegenerative
diseases
S. Lam, A. Bayraktar, C. Zhang, H. Turkez, J. Nielsen, Jan Borén, S. Shoaie, M. Uhlen, A. Mardinoglu
Drug Discovery Today - 2020 -
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin
resistance
K. H. M. Roumans, L. Lindeboom, P. Veeraiah, C. M. E. Remie, E. Phielix, B. Havekes, Y. M. H. Bruls, Mcgj Brouwers, Marcus Ståhlman, M. Alssema, H. P. F. Peters, R. de Mutsert, B. Staels, M. R. Taskinen, Jan Borén, P. Schrauwen, V. B. Schrauwen-Hinderling
Nature Communications - 2020 -
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic
liver
Annika Nerstedt, Yeshwant Kurhe, Emmelie Cansby, Mara Caputo, Lei Gao, Egor Vorontsov, Marcus Ståhlman, Esther Nuñez Durán, Jan Borén, Hanns-Ulrich Marschall, Douglas G. Mashek, D. N. Saunders, Carina Sihlbom, A. J. Hoy, Margit Mahlapuu
Journal of Lipid Research - 2020 -
Apolipoprotein B48 metabolism in chylomicrons and very low-density lipoproteins and its role in triglyceride transport in normo- and hypertriglyceridemic human
subjects
Elias Björnson, C. J. Packard, Martin Adiels, Linda Andersson, N. Matikainen, S. Soderlund, J. Kahri, A. Hakkarainen, N. Lundbom, J. Lundbom, Carina Sihlbom, Annika Thorsell, H. Zhou, M. R. Taskinen, Jan Borén
Journal of Internal Medicine - 2020 -
Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and
EFLM
B. G. Nordestgaard, M. R. Langlois, A. Langsted, M. J. Chapman, K. M. Aakre, H. Baum, Jan Borén, E. Bruckert, A. Catapano, C. Cobbaert, P. Collinson, O. S. Descamps, C. J. Duff, A. von Eckardstein, A. Hammerer-Lercher, P. R. Kamstrup, G. Kolovou, F. Kronenberg, S. Mora, K. Pulkki, A. T. Remaley, N. Rifai, E. Ros, S. Stankovic, A. Stavljenic-Rukavina, G. Sypniewska, G. F. Watts, Olov Wiklund, P. Laitinen, Soc European Atherosclerosis, Chem European Federation Clinical
Atherosclerosis - 2020 -
Current Status of COVID-19 Therapies and Drug Repositioning
Applications
O. Altay, E. Mohammadi, S. Lam, H. Turkez, Jan Borén, J. Nielsen, M. Uhlen, A. Mardinoglu
Iscience - 2020 -
Investigation of human apoB48 metabolism using a new, integrated non-steady-state model of apoB48 and apoB100
kinetics
Elias Björnson, C. J. Packard, Martin Adiels, Linda Andersson, N. Matikainen, S. Soderlund, J. Kahri, Carina Sihlbom, Annika Thorsell, H. Zhou, M. R. Taskinen, Jan Borén
Journal of Internal Medicine - 2019 -
Endothelial repair is dependent on CD11c(+) leukocytes to establish regrowing endothelial sheets with high cellular
density
Ulf Yrlid, Maricris Holm, Malin Levin, Samuel Alsén, Malin Lindbom, Lars Glise, Niklas Bergh, Jan Borén, Per Fogelstrand
Journal of Leukocyte Biology - 2019 -
Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in
humans.
Emmelie Cansby, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Annika Nerstedt, Marcus Ståhlman, Carina Sihlbom, Hanns-Ulrich Marschall, Jan Borén, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2019 -
Vimentin is required for normal accumulation of body
fat
Ulrika Wilhelmsson, Pia Stillemark-Billton, Jan Borén, Milos Pekny
Biological Chemistry - 2019 -
Role of apolipoprotein C-III overproduction in diabetic
dyslipidaemia
Martin Adiels, M. R. Taskinen, Elias Björnson, Linda Andersson, N. Matikainen, S. Söderlund, J. Kahri, A. Hakkarainen, N. Lundbom, Carina Sihlbom, Annika Thorsell, H. Zhou, K. H. Pietiläinen, C. Packard, Jan Borén
Diabetes, obesity and metabolism - 2019 -
Human adipose tissue microvascular endothelial cells secrete PPARγ ligands and regulate adipose tissue lipid
uptake.
Silvia Gogg, Annika Nerstedt, Jan Borén, Ulf Smith
JCI insight - 2019 -
Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and
fluidity
Mario Ruiz, Rakesh Bodhicharla, Marcus Ståhlman, Emma Svensk, Kiran Busayavalasa, H. Palmgren, H. Ruhanen, Jan Borén, Marc Pilon
Elife - 2019 -
Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and
autophagy
P. Saliba-Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, S. Pourteymour, D. Baldassarre, E. Tremoli, F. Veglia, R. Rauramaa, A. J. Smit, P. Giral, S. Kurl, M. Pirro, U. de Faire, S. E. Humphries, A. Hamsten, I. Goncalves, M. Orho-Melander, A. Franco-Cereceda, Jan Borén, P. Eriksson, J. Magne, P. Parini, E. Ehrenborg, C. R. Sirtori, S. Castelnuovo, M. Amato, B. Frigerio, A. Ravani, D. Sansaro, C. Tedesco, F. Bovis, A. Discacciati, M. Ahl, G. Blomgren, M. J. Eriksson, P. Fahlstadius, M. Heinonen, L. Nilson, J. Cooper, J. Acharya, K. Huttunen, E. Rauramaa, H. Pekkarinen, I. M. Penttila, J. Torronen, A. I. van Gessel, A. M. van Roon, G. C. Teune, W. D. Kuipers, M. Bruin, A. Nicolai, P. Haarsma-Jorritsma, D. J. Mulder, H. J. G. Bilo, G. H. Smeets, J. L. Beaudeux, J. F. Kahn, V. Carreau, A. Kontush, J. Karppi, T. Nurmi, K. Nyyssonen, R. Salonen, T. P. Tuomainen, J. Tuomainen, J. Kauhanen, G. Vaudo, A. Alaeddin, D. Siepi, G. Lupattelli, G. Schillaci
Journal of Internal Medicine - 2019 -
Systems biology perspective for studying the gut microbiota in human physiology and liver
diseases
O. Altay, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Ebiomedicine - 2019 -
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during
ischemia
Martina Klevstig, M. Arif, M. Mannila, S. Svedlund, Ismena Mardani, Marcus Ståhlman, Linda Andersson, Malin Lindbom, Azra Miljanovic, A. Franco-Cereceda, P. Eriksson, Anders Jeppsson, Li-Ming Gan, Malin Levin, A. Mardinoglu, E. Ehrenborg, Jan Borén
Journal of Molecular and Cellular Cardiology - 2019 -
AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of
adiponectin
Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
Journal of Lipid Research - 2019 -
Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the
heart.
Ismena Mardani, Dalen Knut Tomas, Christina Drevinge, Azra Miljanovic, Marcus Ståhlman, Martina Klevstig, Margareta Scharin Täng, Per Fogelstrand, Max Levin, Matias Ekstrand, Syam Nair, Björn Redfors, Elmir Omerovic, Linda Andersson, Kimmel Alan R, Jan Borén, Malin Levin
Scientific reports - 2019 -
Disturbed Laminar Blood Flow Causes Impaired Fibrinolysis and Endothelial Fibrin Deposition In
Vivo.
Lars Glise, Pia Larsson, Sverker Jern, Jan Borén, Malin Levin, Tor Ny, Per Fogelstrand, Niklas Bergh
Thrombosis and haemostasis - 2019 -
In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse
model
A. Carreras, L. S. Pane, R. Nitsch, K. Madeyski-Bengtson, M. Porritt, P. Akcakaya, A. Taheri-Ghahfarokhi, E. Ericson, M. Bjursell, M. Perez-Alcazar, F. Seeliger, M. Althage, R. Knoll, R. Hicks, L. M. Mayr, Rosie Perkins, D. Linden, Jan Borén, M. Bohlooly-Y, M. Maresca
Bmc Biology - 2019 -
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial
function
Z. T. Liu, C. Zhang, S. Lee, W. Kim, Martina Klevstig, A. M. Harzandi, N. Sikanic, M. Arif, Marcus Ståhlman, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Metabolic Engineering - 2019 -
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network
analysis
R. Benfeitas, G. Bidkhori, B. Mukhopadhyay, Martina Klevstig, M. Arif, C. Zhang, S. Lee, R. Cinar, J. Nielsen, M. Uhlen, Jan Borén, G. Kunos, A. Mardinoglu
Ebiomedicine - 2019 -
Crosstalk between nonalcoholic fatty liver disease and cardiometabolic
syndrome
S. Lim, M. R. Taskinen, Jan Borén
Obesity Reviews - 2019 -
Localised lipid accumulation detected in infarcted mouse heart tissue using
ToF-SIMS
S. Samfors, Marcus Ståhlman, Martina Klevstig, Jan Borén, John S. Fletcher
International Journal of Mass Spectrometry - 2019 -
Dietary Fructose and the Metabolic
Syndrome
M. R. Taskinen, C. J. Packard, Jan Borén
Nutrients - 2019 -
The Potential Use of Metabolic Cofactors in Treatment of
NAFLD
A. Mardinoglu, D. Ural, M. Zeybel, H. H. Yuksel, M. Uhlen, Jan Borén
Nutrients - 2019 -
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic
Fatty Liver Disease.
Emmelie Cansby, Esther Nuñez Durán, Elin Magnusson, Manoj Amrutkar, Sheri L Booten, Nagaraj M. Kulkarni, L Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Cellular and molecular gastroenterology and hepatology - 2019 -
Liraglutide treatment improves postprandial lipid metabolism and cardiometabolic risk factors in humans with adequately controlled type 2 diabetes: A single-centre randomized controlled
study
N. Matikainen, S. Soderlund, Elias Björnson, K. Pietilainen, A. Hakkarainen, N. Lundbom, M. R. Taskinen, Jan Borén
Diabetes Obesity & Metabolism - 2019 -
Overeating Saturated Fat Promotes Fatty Liver and Ceramides Compared With Polyunsaturated Fat: A Randomized
Trial
F. Rosqvist, J. Kullberg, Marcus Ståhlman, J. Cedernaes, Kerstin Heurling, H. E. Johansson, D. Iggman, H. Wilking, A. Larsson, O. Eriksson, L. Johansson, S. Straniero, M. Rudling, G. Antoni, M. Lubberink, M. Orho-Melander, Jan Borén, H. Ahlström, U. Risérus
The Journal of clinical endocrinology and metabolism - 2019 -
Targeting filamin A reduces macrophage activity and
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand, Sravani Devarakonda, Joakim Karlsson, Jimmy Van den Eynden, Göran Bergström, Max Levin, Jan Borén, Martin O. Bergö, Levent Akyürek
Circulation - 2019 -
Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network
analysis
Martin Adiels, M. J. Chapman, P. Robillard, M. Krempf, M. Laville, Jan Borén, Grp Niacin Study
Journal of Clinical Lipidology - 2018 -
Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe(-/-)
Mice
Annika Lindskog Jonsson, Robert Caesar, Rozita Akrami, Christopher Reinhardt, Frida Fåk, Jan Borén, Fredrik Bäckhed
Arteriosclerosis Thrombosis and Vascular Biology - 2018 -
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of
Hypercholesterolemia
Emmelie Cansby, Elin Magnusson, Esther Nuñez Durán, M. Amrutkar, M. Pedrelli, P. Parini, Jenny M Hoffmann, Marcus Ståhlman, B. W. Howell, Hanns-Ulrich Marschall, Jan Borén, Margit Mahlapuu
Arteriosclerosis Thrombosis and Vascular Biology - 2018 -
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in
mice
Liliana Håversen, J. P. Sundelin, A. Mardinoglu, Mikael Rutberg, Marcus Ståhlman, Ulrika Wilhelmsson, Lillemor Mattsson Hultén, Milos Pekny, Per Fogelstrand, J. F. Bentzon, Malin Levin, Jan Borén
Scientific Reports - 2018 -
Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in
Life.
Jennifer G Robinson, Kevin Jon Williams, Samuel Gidding, Jan Borén, Ira Tabas, Edward A Fisher, Chris Packard, Michael Pencina, Zahi A Fayad, Venkatesh Mani, Kerry Anne Rye, Børge G Nordestgaard, Anne Tybjærg-Hansen, Pamela S Douglas, Stephen J Nicholls, Neha Pagidipati, Allan Sniderman
Journal of the American Heart Association - 2018 -
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and
metabolome
A. Lovric, M. Graner, E. Bjornson, M. Arif, R. Benfeitas, K. Nyman, Marcus Ståhlman, M. O. Pentikainen, J. Lundborn, A. Hakkarainen, R. Siren, M. S. Nieminen, N. Lundborns, K. Lauermas, M. R. Taskinen, A. Mardinoglu, Jan Borén
Scientific Reports - 2018 -
Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in
silico
E. Mobarak, Liliana Håversen, M. Manna, Mikael Rutberg, Malin Levin, Rosie Perkins, T. Rog, I. Vattulainen, Jan Borén
Scientific Reports - 2018 -
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in
mice.
Esther Nuñez Durán, Mariam Aghajan, Manoj Amrutkar, Silva Sütt, Emmelie Cansby, Sheri L Booten, Andrew Watt, Marcus Ståhlman, Norbert Stefan, Hans-Ulrich Häring, Harald Staiger, Jan Borén, Hanns-Ulrich Marschall, Margit Mahlapuu
Hepatology communications - 2018 -
New prospects for PCSK9
inhibition?
Jan Borén, Olov Wiklund
European heart journal - 2018 -
Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting
MS
Lenka Novakova, Avadhesh Kumar Singh, Markus Axelsson, Marcus Ståhlman, Martin Adiels, Clas Malmeström, Henrik Zetterberg, Jan Borén, Jan Lycke, Susanna Cardell, Maria K. Blomqvist
Journal of Neurochemistry - 2018 -
Drug Repositioning for Effective Prostate Cancer
Treatment
B. Turanli, Morten Grötli, Jan Borén, J. Nielsen, M. Uhlen, K. Y. Arga, A. Mardinoglu
Frontiers in Physiology - 2018 -
Systems biology in hepatology: approaches and
applications
A. Mardinoglu, Jan Borén, Ulf Smith, M. Uhlen, J. Nielsen
Nature Reviews Gastroenterology & Hepatology - 2018 -
2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic cardiovascular disease or in familial
hypercholesterolaemia.
Ulf Landmesser, M John Chapman, Jane K Stock, Pierre Amarenco, Jill J F Belch, Jan Borén, Michel Farnier, Brian A Ference, Stephan Gielen, Ian Graham, Diederick E Grobbee, G Kees Hovingh, Thomas F Lüscher, Massimo F Piepoli, Kausik K Ray, Erik S Stroes, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano, Fausto Pinto, Lale Tokgözoglu, Jeroen J Bax, Alberico L Catapano
European heart journal - 2018 -
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in
Humans
A. Mardinoglu, Hao Wu, Elias Björnson, C. Zhang, A. Hakkarainen, S. M. Rasanen, S. Lee, Rosellina Margherita Mancina, Mattias Bergentall, K. H. Pietilainen, S. Soderlund, N. Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, B. D. Piening, M. Graner, N. Lundbom, Kevin Jon Williams, Stefano Romeo, J. Nielsen, M. Snyder, M. Uhlen, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, M. R. Taskinen, Jan Borén
Cell Metabolism - 2018 -
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2
Diabetes
A. Mardinoglu, Silvia Gogg, L. A. Lotta, A. Stancakova, Annika Nerstedt, Jan Borén, M. Bluher, E. Ferrannini, C. Langenberg, N. J. Wareham, M. Laakso, Ulf Smith
Ebiomedicine - 2018 -
Membrane fluidity is regulated by the C-elegans transmembrane protein FLD-1 and its human homologs
TLCD1/2
Mario Ruiz, Rakesh Bodhicharla, Emma Svensk, Ranjan Devkota, Kiran Busayavalasa, Henrik Palmgren, Marcus Ståhlman, Jan Borén, Marc Pilon
eLife - 2018 -
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor
subtypes
G. Bidkhori, R. Benfeitas, Martina Klevstig, C. Zhang, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Proceedings of the National Academy of Sciences of the United States of America - 2018 -
TCSBN: a database of tissue and cancer specific biological
networks
S. Lee, C. Zhang, M. Arif, Z. T. Liu, R. Benfeitas, G. Bidkhori, S. Deshmukh, M. Al Shobky, A. Lovric, Jan Borén, J. Nielsen, M. Uhlen, A. Mardinoglu
Nucleic Acids Research - 2018 -
Characterisation of patients with familial chylomicronaemia syndrome (FCS) and multifactorial chylomicronaemia syndrome (MCS): Establishment of an FCS clinical diagnostic
score
P. Moulin, R. Dufour, M. Averna, M. Arca, A. B. Cefalù, D. Noto, L. D'Erasmo, A. Di Costanzo, C. Marçais, L. A. A. S. Walther, M. Banach, Jan Borén, R. Cramb, I. Gouni-Berthold, E. Hughes, C. Johnson, X. Pintó, Z. Reiner, J. R. van Lennep, H. Soran, C. Stefanutti, E. Stroes, E. Bruckert
Data in Brief - 2018 -
Identification and diagnosis of patients with familial chylomicronaemia syndrome (FCS): Expert panel recommendations and proposal of an “FCS
score”
P. Moulin, R. Dufour, M. Averna, M. Arca, A. B. Cefalù, D. Noto, L. D'Erasmo, A. Di Costanzo, C. Marçais, L. A. Alvarez-Sala Walther, M. Banach, Jan Borén, R. Cramb, I. Gouni-Berthold, E. Hughes, C. Johnson, X. Pintó, Ž Reiner, J. R. van Lennep, H. Soran, C. Stefanutti, E. Stroes, E. Bruckert
Atherosclerosis - 2018 -
Improving the economics of NASH/NAFLD treatment through the use of systems
biology
J. Bosley, C. Boren, S. Lee, Morten Grötli, J. Nielsen, M. Uhlen, Jan Borén, A. Mardinoglu
Drug Discovery Today - 2017 -
High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and
UPLC-MS/MS
Maria K. Blomqvist, Jan Borén, Henrik Zetterberg, Kaj Blennow, Jan-Eric Månsson, Marcus Ståhlman
Journal of Lipid Research - 2017 -
Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian
family
E. Nikkola, A. Ko, M. Alvarez, R. M. Cantor, K. Garske, E. Kim, S. Gee, A. Rodriguez, R. Muxel, N. Matikainen, S. Soderlund, M. M. Motazacker, Jan Borén, C. Lamina, F. Kronenberg, W. J. Schneider, A. Palotie, M. Laakso, M. R. Taskinen, P. Pajukanta
Atherosclerosis - 2017 -
The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty
acids.
Ranjan Devkota, Emma Svensk, Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
PLoS genetics - 2017 -
Network analyses identify liver-specific targets for treating liver
diseases.
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Borén, Adil Mardinoglu
Molecular systems biology - 2017 -
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse
hearts.
Linda Andersson, Christina Drevinge, Ismena Mardani, Knut T Dalen, Marcus Ståhlman, Martina Klevstig, Annika Lundqvist, Fred Haugen, Martin Adiels, Per Fogelstrand, Jorge Asin-Cayuela, Lillemor Mattsson Hultén, Max Levin, Ewa Ehrenborg, Yun K Lee, Alan R Kimmel, Jan Borén, Malin Levin
The international journal of biochemistry & cell biology - 2017 -
Intimal hyperplasia induced by vascular intervention causes lipoprotein retention and accelerated
atherosclerosis
Siavash Kijani, A. M. Vazquez, Malin Levin, Jan Borén, Per Fogelstrand
Physiological Reports - 2017 -
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular
Disease.
Adil Mardinoglu, Alena Stančáková, Luca A Lotta, Johanna Kuusisto, Jan Borén, Matthias Blüher, Nicholas J Wareham, Ele Ferrannini, Per Henrik Groop, Markku Laakso, Claudia Langenberg, Ulf Smith
Cell metabolism - 2017 -
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in
NAFLD
A. Mardinoglu, Elias Björnson, C. Zhang, Martina Klevstig, S. Soderlund, Marcus Ståhlman, Martin Adiels, A. Hakkarainen, N. Lundbom, M. Kilicarslan, B. M. Hallstrom, J. Lundbom, B. Verges, P. H. R. Barrett, G. F. Watts, M. J. Serlie, J. Nielsen, M. Uhlen, Ulf Smith, Hanns-Ulrich Marschall, M. R. Taskinen, Jan Borén
Molecular Systems Biology - 2017 -
Kinetics of plasma triglycerides in abdominal
obesity.
Elias Björnson, Martin Adiels, Marja-Riitta Taskinen, Jan Borén
Current opinion in lipidology - 2017 -
Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus
Panel.
Jan Borén, Olov Wiklund
European heart journal - 2017 -
Depletion of ATP and glucose in advanced human atherosclerotic
plaques
Matias Ekstrand, Emma Widell, Anna Hammar, Levent Akyürek, Martin Johansson, Björn Fagerberg, Göran Bergström, Malin Levin, Per Fogelstrand, Jan Borén, Max Levin
PLoS One - 2017 -
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal
muscle.
Urszula Chursa, Esther Nuñez Durán, Emmelie Cansby, Manoj Amrutkar, Silva Sütt, Marcus Ståhlman, Britt-Marie Olsson, Jan Borén, Maria Johansson, Fredrik Bäckhed, Bengt R Johansson, Carina Sihlbom, Margit Mahlapuu
Diabetologia - 2017 -
Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal
obesity
M. R. Taskinen, S. Söderlund, L. H. Bogl, A. Hakkarainen, N. Matikainen, K. H. Pietiläinen, S. Räsänen, N. Lundbom, Elias Björnson, Björn Eliasson, Rosellina Margherita Mancina, Stefano Romeo, N. Alméras, G. D. Pepa, C. Vetrani, A. Prinster, G. Annuzzi, A. Rivellese, J. P. Després, Jan Borén
Journal of Internal Medicine - 2017 -
Dietary Omega-3 Fatty Acids Increase Survival and Decrease Bacterial Load in Mice Subjected to Staphylococcus aureus-Induced
Sepsis
Sara L Svahn, Marcus A Ulleryd, Louise Grahnemo, Marcus Ståhlman, Jan Borén, Staffan Nilsson, John-Olov Jansson, Maria E Johansson
Infection and Immunity - 2016 -
Catch and Release: NG2-Coated Vascular Smooth Muscle Cells Capture Lipoproteins for
Macrophages
Per Fogelstrand, Jan Borén
Arteriosclerosis, Thrombosis, and Vascular Biology - 2016 -
The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of
simplicity
Jan Borén, Kevin Jon Williams
Current Opinion in Lipidology - 2016 -
ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal
Obesity.
Bruno Vergès, Martin Adiels, Jan Borén, Peter Hugh Barrett, Gerald F Watts, Dick Chan, Laurence Duvillard, Sanni Söderlund, Niina Matikainen, Juhani Kahri, Nina Lundbom, Jesper Lundbom, Antti Hakkarainen, Serge Aho, Isabelle Simoneau-Robin, Marja-Riitta Taskinen
The Journal of clinical endocrinology and metabolism - 2016 -
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin
Resistance
S. Lee, C. Zhang, M. Kilicarslan, B. D. Piening, Elias Björnson, B. M. Hallstrom, A. K. Groen, E. Ferrannini, M. Laakso, M. Snyder, M. Bluher, M. Uhlen, Jens B. Nielsen, Ulf Smith, M. J. Serlie, Jan Borén, Adil Mardinoglu
Cell Metabolism - 2016 -
Cerebrospinal fluid-induced retardation of amyloid beta aggregation correlates with Alzheimer's disease and the APOE epsilon 4
allele
Eden R. Padayachee, Henrik Zetterberg, Erik Portelius, Jan Borén, J. L. Molinuevo, N. Andreasen, R. Cukalevski, S. Linse, Kaj Blennow, Ulf Andreasson
Brain Research - 2016 -
STK25 is a critical determinant in nonalcoholic
steatohepatitis.
Manoj Amrutkar, Urszula Chursa, Matthias Kern, Esther Nuñez Durán, Marcus Ståhlman, Silva Sütt, Jan Borén, Bengt R Johansson, Hanns-Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2016 -
Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular
Disease?
M. R. Taskinen, Jan Borén
Current Atherosclerosis Reports - 2016 -
Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and
apoC-III
E. M. Ooi, D. C. Chan, L. Hodson, Martin Adiels, Jan Borén, F. Karpe, B. A. Fielding, G. F. Watts, P. H. R. Barrett
European Journal of Clinical Investigation - 2016 -
Perilipin 5 is protective in the ischemic
heart
Christina Drevinge, K. T. Dalen, M. N. Mannila, Margareta Scharin Täng, Marcus Ståhlman, Martina Klevstig, Annika Lundqvist, Ismena Mardani, F. Haugen, Per Fogelstrand, Martin Adiels, Jorge Asin-Cayuela, C. Ekestam, J. R. Gadin, Y. K. Lee, H. Nebb, Sara Svedlund, Bengt R Johansson, Lillemor Mattsson Hultén, Stefano Romeo, Björn Redfors, Elmir Omerovic, Max Levin, Li-Ming Gan, P. Eriksson, Linda Andersson, E. Ehrenborg, A. R. Kimmel, Jan Borén, Malin Levin
International Journal of Cardiology - 2016 -
Triglyceride-Rich Lipoproteins and Remnants: Targets for
Therapy?
G. M. Dallinga-Thie, J. Kroon, Jan Borén, M. J. Chapman
Current Cardiology Reports - 2016 -
Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes
patients
Emanuel Fryk, Jeanna Perman Sundelin, Lena Strindberg, Maria J Pereira, M. Federici, N. Marx, Helena Filipsson Nyström, M. Schmelz, Per-Arne Svensson, Jan W Eriksson, Jan Borén, Per-Anders Jansson
Metabolism-Clinical and Experimental - 2016 -
Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary
metabolites.
Claudia Vetrani, Angela A Rivellese, Giovanni Annuzzi, Martin Adiels, Jan Borén, Ismo Mattila, Matej Orešič, Anna-Marja Aura
The Journal of nutritional biochemistry - 2016 -
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European
Descent.
Rosellina Margherita Mancina, Paola Dongiovanni, Salvatore Petta, Piero Pingitore, Marica Meroni, Raffaela Rametta, Jan Borén, Tiziana Montalcini, Arturo Pujia, Olov Wiklund, George Hindy, Rocco Spagnuolo, Benedetta Maria Motta, Rosaria Maria Pipitone, Antonio Craxì, Silvia Fargion, Valerio Nobili, Pirjo Käkelä, Vesa Kärjä, Ville Männistö, Jussi Pihlajamäki, Dermot F Reilly, Jose Castro-Perez, Julia Kozlitina, Luca Valenti, Stefano Romeo
Gastroenterology - 2016 -
Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic
heart
Martina Klevstig, Marcus Ståhlman, Annika Lundqvist, Margareta Scharin Täng, Per Fogelstrand, Martin Adiels, Linda Andersson, R. Kolesnick, Anders Jeppsson, Jan Borén, Malin Levin
Journal of Molecular and Cellular Cardiology - 2016 -
A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty
acids.
Tejia Zhang, Shili Chen, Ismail Syed, Marcus Ståhlman, Matthew J Kolar, Edwin A Homan, Qian Chu, Ulf Smith, Jan Borén, Barbara B Kahn, Alan Saghatelian
Nature Protocols - 2016 -
Biomarkers and prediction of myocardial triglyceride content in non-diabetic
men
Marit Granér, Sara Gustavsson, Kristofer Nyman, Reijo Siren, Markku Pentikäinen, Jesse Lundbom, Antti Hakkarainen, Kirsi Lauerma, Nina Lundbom, Jan Borén, Markku Nieminen, Marja-Riitta Taskinen
NMCD. Nutrition Metabolism and Cardiovascular Diseases - 2016 -
Confounding effects of metformin on the human gut microbiome in Type 2
diabetes
Adil Mardinoglu, Jan Borén, Ulf Smith
Cell Metabolism - 2016 -
Minor contribution of endogenous GLP-1 and GLP-2 to postprandial lipemia in obese
men
N. Matikainen, Elias Björnson, S. Söderlund, Christofer Borén, Björn Eliasson, K. H. Pietiläinen, L. H. Bogl, A. Hakkarainen, N. Lundbom, A. Rivellese, G. Riccardi, J. P. Després, N. Alméras, J. J. Holst, C. F. Deacon, Jan Borén, M. R. Taskinen
PLoS ONE - 2016 -
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in
humans
Manoj Amrutkar, M. Kern, Esther Nuñez Durán, Marcus Ståhlman, Emmelie Cansby, Urszula Chursa, Elin Stenfeldt, Jan Borén, M. Bluher, Margit Mahlapuu
Diabetologia - 2016 -
Liver receptor homolog-1 is a critical determinant of methyl-pool
metabolism
M. Wagner, S. Choi, K. Panzitt, J. L. Mamrosh, J. M. Lee, A. Zaufel, R. Xiao, R. Wooton-Kee, Marcus Ståhlman, C. B. Newgard, Jan Borén, D. D. Moore
Hepatology - 2016 -
Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth
factor-I.
Johan Svensson, Klara Sjögren, Malin Levin, Jan Borén, Åsa Tivesten, Claes Ohlsson
Endocrine - 2016 -
Caenorhabditis elegans PAQR-2 and IGLR-2 protect against glucose toxicity by modulating membrane lipid
composition
Emma Svensk, Ranjan Devkota, Marcus Ståhlman, Parmida Ranji, Manish Rauthan, Fredrik Magnusson, Sofia Hammarsten, Maja Johansson, Jan Borén, Marc Pilon
PLoS Genetics - 2016 -
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid
metabolism
Aditi Chaudhari, Liliana Håversen, Reza Mobini, Linda Andersson, Marcus Ståhlman, Emma Lu, Mikael Rutberg, Per Fogelstrand, Kim Ekroos, Adil Mardinoglu, Malin Levin, Rosie Perkins, Jan Borén
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids - 2016 -
Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory
Medicine.
Børge G Nordestgaard, Anne Langsted, Samia Mora, Genovefa Kolovou, Hannsjörg Baum, Eric Bruckert, Gerald F Watts, Grazyna Sypniewska, Olov Wiklund, Jan Borén, M John Chapman, Christa Cobbaert, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Kari Pulkki, Florian Kronenberg, Alan T Remaley, Nader Rifai, Emilio Ros, Michel Langlois
European heart journal - 2016 -
Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints-A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory
Medicine.
Børge G Nordestgaard, Anne Langsted, Samia Mora, Genovefa Kolovou, Hannsjörg Baum, Eric Bruckert, Gerald F Watts, Grazyna Sypniewska, Olov Wiklund, Jan Borén, M John Chapman, Christa Cobbaert, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Kari Pulkki, Florian Kronenberg, Alan T Remaley, Nader Rifai, Emilio Ros, Michel Langlois
Clinical chemistry - 2016 -
p110alpha hot spot mutations E545K and H1047R exert metabolic reprogramming independently of p110alpha kinase
activity
Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent Akyürek, Sashidar Bandaru, Kristina Skålen, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, Victoria Rotter Sopasakis
Molecular and Cellular Biology - 2015 -
Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or
Atorvastatin
Matias Ekstrand, Maria Gustafsson Trajkovska, Jeanna Perman Sundelin, Per Fogelstrand, Martin Adiels, M. Johansson, Lillemor Mattsson Hultén, Jan Borén, Max Levin
Plos One - 2015 -
De novo lipogenesis in metabolic homeostasis: More friend than
foe?
Giovanni Solinas, Jan Borén, A. G. Dulloo
Molecular Metabolism - 2015 -
The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female
mice.
Johan Bourghardt Fagman, Anna S K Wilhelmson, Benedetta Maria Motta, Carlo Pirazzi, Camilla Alexanderson, Karel De Gendt, Guido Verhoeven, Agneta Holmäng, Fredrik Anesten, John-Olov Jansson, Malin Levin, Jan Borén, Claes Ohlsson, Alexandra Krettek, Stefano Romeo, Åsa Tivesten
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2015 -
Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in
Humans.
Martin Adiels, Adil Mardinoglu, Marja-Riitta Taskinen, Jan Borén
Frontiers in Physiology - 2015 -
Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in
Women
L. Hodson, R. Banerjee, B. Rial, W. Arlt, Martin Adiels, Jan Borén, K. Marinou, C. Fisher, I. L. Mostad, I. M. Stratton, P. H. R. Barrett, D. C. Chan, G. F. Watts, K. Harnden, F. Karpe, B. A. Fielding
Journal of the American Heart Association - 2015 -
C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic
Lesions
Alex-Xianghua Zhou, X. B. Wang, C. S. Lin, J. Han, J. Yong, M. J. Nadolski, Jan Borén, R. J. Kaufman, I. Tabas
Circulation Research - 2015 -
Atrial fibrillation in patients admitted to coronary care units in western Sweden - focus on obesity and
lipotoxicity.
Sigfus Gizurarson, Marcus Ståhlman, Anders Jeppsson, Yangzhen Shao, Björn Redfors, Lennart Bergfeldt, Jan Borén, Elmir Omerovic
Journal of electrocardiology - 2015 -
The small leucine-rich repeat proteoglycans in tissue repair and
atherosclerosis
A. Hultgardh-Nilsson, Jan Borén, S. Chakravarti
Journal of Internal Medicine - 2015 -
Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects
Models
Martin Berglund, Martin Adiels, M. R. Taskinen, Jan Borén, Bernt Wennberg
PLoS ONE - 2015 -
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial
ischemia
Linda Andersson, Margareta Scharin Täng, Annika Lundqvist, Malin Lindbom, Ismena Mardani, Per Fogelstrand, Puja Shahrouki, Björn Redfors, Elmir Omerovic, Max Levin, Jan Borén, Malin Levin
Cardiovascular Research - 2015 -
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and
treatment.
Albert Wiegman, Samuel S Gidding, Gerald F Watts, M John Chapman, Henry N Ginsberg, Marina Cuchel, Leiv Ose, Maurizio Averna, Catherine Boileau, Jan Borén, Eric Bruckert, Alberico L Catapano, Joep C Defesche, Olivier S Descamps, Robert A Hegele, G Kees Hovingh, Steve E Humphries, Petri T Kovanen, Jan Albert Kuivenhoven, Luis Masana, Børge G Nordestgaard, Päivi Pajukanta, Klaus G Parhofer, Frederick J Raal, Kausik K Ray, Raul D Santos, Anton F H Stalenhoef, Elisabeth Steinhagen-Thiessen, Erik S Stroes, Marja-Riitta Taskinen, Anne Tybjærg-Hansen, Olov Wiklund
European heart journal - 2015 -
Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity Multicenter Tracer Kinetic
Study
Jan Borén, G. F. Watts, Martin Adiels, S. Soderlund, D. C. Chan, A. Hakkarainen, N. Lundbom, N. Matikainen, J. Kahri, B. Verges, P. H. R. Barrett, M. R. Taskinen
Arteriosclerosis Thrombosis and Vascular Biology - 2015 -
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes
Model
Manoj Amrutkar, Emmelie Cansby, Urszula Chursa, Esther Nuñez Durán, Belén Chanclón, Marcus Ståhlman, Vincent Fridén, Louise Mannerås Holm, Anna Wickman, Ulf Smith, Fredrik Bäckhed, Jan Borén, B. W. Howell, Margit Mahlapuu
Diabetes - 2015 -
Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence
Variant
Rosellina Margherita Mancina, N. Matikainen, Cristina Maglio, S. Soderlund, N. Lundbom, A. Hakkarainen, R. Rametta, E. Mozzi, S. Fargion, L. Valenti, Stefano Romeo, M. R. Taskinen, Jan Borén
Journal of Clinical Endocrinology & Metabolism - 2015 -
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and
NASH
Manoj Amrutkar, Emmelie Cansby, Esther Nuñez Durán, Carlo Pirazzi, Marcus Ståhlman, Elin Stenfeldt, Ulf Smith, Jan Borén, Margit Mahlapuu
Faseb Journal - 2015 -
Filter-Dense Multicolor
Microscopy
Siavash Kijani, Ulf Yrlid, Maria Heyden, Malin Levin, Jan Borén, Per Fogelstrand
Plos One - 2015 -
New insights into the pathophysiology of dyslipidemia in type 2
diabetes
M. R. Taskinen, Jan Borén
Atherosclerosis - 2015 -
Transmembrane 6 Superfamily Member 2 Gene Variant Disentangles Nonalcoholic Steatohepatitis From Cardiovascular
Disease
P. Dongiovanni, S. Petta, Cristina Maglio, A. L. Fracanzani, R. Pipitone, E. Mozzi, Benedetta Maria Motta, D. Kaminska, R. Rametta, S. Grimaudo, S. Pelusi, T. Montalcini, A. Alisi, M. Maggioni, V. Karja, Jan Borén, P. Kakela, V. Di Marco, C. Xing, V. Nobili, B. Dallapiccola, A. Craxi, J. Pihlajamaki, S. Fargion, Lars Sjöström, Lena M S Carlsson, Stefano Romeo, L. Valenti
Hepatology - 2015 -
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and
management
R. A. Hegele, H. N. Ginsberg, M. J. Chapman, B. G. Nordestgaard, J. A. Kuivenhoven, M. Averna, Jan Borén, E. Bruckert, A. L. Catapano, O. S. Descamps, G. K. Hovingh, S. E. Humphries, P. T. Kovanen, L. Masana, P. Pajukanta, K. G. Parhofer, F. J. Raal, K. K. Ray, R. D. Santos, A. F. H. Stalenhoef, E. Stroes, M. R. Taskinen, A. Tybjrg-Hansen, G. F. Watts, Olov Wiklund
Lancet Diabetes & Endocrinology - 2014 -
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis
Society
M. Cuchel, E. Bruckert, H. N. Ginsberg, F. J. Raal, R. D. Santos, R. A. Hegele, J. A. Kuivenhoven, B. G. Nordestgaard, O. S. Descamps, E. Steinhagen-Thiessen, A. Tybjrg-Hansen, G. F. Watts, M. Averna, C. Boileau, Jan Borén, A. L. Catapano, J. C. Defesche, G. K. Hovingh, S. E. Humphries, P. T. Kovanen, L. Masana, P. Pajukanta, K. G. Parhofer, K. K. Ray, A. F. H. Stalenhoef, E. Stroes, M. R. Taskinen, A. Wiegman, Olov Wiklund, M. J. Chapman
European Heart Journal - 2014 -
Lipid metabolism in metabolic
syndrome
Jan Borén, Martin Adiels
A Systems Biology Approach to Study Metabolic Syndrome - 2014 -
Interrelationships Between the Kinetics of VLDL Subspecies and HDL Catabolism in Abdominal Obesity: A Multicenter Tracer Kinetic
Study
B. Verges, Martin Adiels, Jan Borén, P. H. Barrett, G. F. Watts, D. Chan, L. Duvillard, S. Soderlund, N. Matikainen, J. Kahri, I. Robin, M. R. Taskinen
Journal of Clinical Endocrinology & Metabolism - 2014 -
Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular
disease
H. Gylling, J. Plat, S. Turley, H. N. Ginsberg, Lars Ellegård, W. Jessup, P. J. Jones, D. Lütjohann, W. Maerz, L. Masana, G. Silbernagel, B. Staels, Jan Borén, A. L. Catapano, G. De Backer, J. Deanfield, O. S. Descamps, P. T. Kovanen, G. Riccardi, L. Tokgözoglu, M. J. Chapman
Atherosclerosis - 2014 -
Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating
p53
Volkan I. Sayin, Omar M. Khan, Lara Pehlivanoglu, Anna Staffas, Mohamed X Ibrahim, Annika Asplund, Pia Ågren, Anna Nilton, Göran Bergström, Martin Bergö, Jan Borén, Per Lindahl
Circulation Research - 2014 -
Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic
mice
Maria E Johansson, X. Y. Zhang, K. Edfeldt, A. M. Lundberg, Malin Levin, Jan Borén, W. Li, X. M. Yuan, L. Folkersen, P. Eriksson, U. Hedin, H. Low, D. Sviridov, F. J. Rios, G. K. Hansson, Z. Q. Yan
European Journal of Immunology - 2014 -
Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in
vivo
A. Akhmedov, I. Rozenberg, F. Paneni, G. G. Camici, Y. Shi, C. Doerries, A. Sledzinska, P. Mocharla, A. Breitenstein, C. Lohmann, S. Stein, T. von Lukowicz, M. O. Kurrer, Jan Borén, B. Becher, F. C. Tanner, U. Landmesser, C. M. Matter, T. F. Luscher
European Heart Journal - 2014 -
Genetic diagnosis of familial hypercholesterolaemia by targeted next-generation
sequencing.
Cristina Maglio, Rosellina Margherita Mancina, Benedetta Maria Motta, Marianne Stef, Carlo Pirazzi, Lourdes Palacios, Narwan Askaryar, Jan Borén, Olov Wiklund, Stefano Romeo
Journal of internal medicine - 2014 -
Hepatic Lipogenesis and a Marker of Hepatic Lipid Oxidation, Predict Postprandial Responses of Triglyceride-rich
Lipoproteins
N. Matikainen, Martin Adiels, S. Soderlund, S. Stennabb, T. Ahola, A. Hakkarainen, Jan Borén, M. R. Taskinen
Obesity - 2014 -
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate
cells
Carlo Pirazzi, L. Valenti, Benedetta Maria Motta, Piero Pingitore, Kristina Hedfalk, Rosellina Margherita Mancina, Maria Antonella Burza, C. Indiveri, Y. Ferro, T. Montalcini, Cristina Maglio, P. Dongiovanni, S. Fargion, R. Rametta, A. Pujia, Linda Andersson, Saswati Ghosal, Malin Levin, Olov Wiklund, M. Iacovino, Jan Borén, Stefano Romeo
Human Molecular Genetics - 2014 -
Adipose Tissue-Derived Human Serum Amyloid A Does Not Affect Atherosclerotic Lesion Area in hSAA(+/) (-/)ApoE(-/-)
Mice
Sofie Ahlin, Maja Olsson, Anna S K Wilhelmson, Kristina Skålen, Jan Borén, Lena M S Carlsson, Per-Arne Svensson, Kajsa Sjöholm
Plos One - 2014 -
Postprandial hypertriglyceridemia as a coronary risk
factor.
Jan Borén, Niina Matikainen, Martin Adiels, Marja-Riitta Taskinen
Clinica chimica acta; international journal of clinical chemistry - 2014 -
Hypoxia-induced and calpain-dependent cleavage of filamin-A regulates the hypoxic
response.
Xiaowei Zheng, Alex-Xianghua Zhou, Pegah Rouhi, Hidetaka Uramoto, Jan Borén, Yihai Cao, Teresa Pereira, Levent Akyürek, Lorenz Poellinger
Proceedings of the National Academy of Science of the United States of America - 2014 -
Ceramides are associated with inflammatory processes in human mediastinal adipose
tissue
J. Gertow, S. Kjellqvist, Marcus Ståhlman, L. Cheung, Johan Gottfries, O. Werngren, Jan Borén, A. Franco-Cereceda, P. Eriksson, R. M. Fisher
NMCD. Nutrition Metabolism and Cardiovascular Diseases - 2014 -
Clinical impact of direct HDLc and LDLc method bias in hypertriglyceridemia. A simulation study of the EAS-EFLM Collaborative Project
Group.
Michel R Langlois, Olivier S Descamps, Arnoud van der Laarse, Cas Weykamp, Hannsjörg Baum, Kari Pulkki, Arnold von Eckardstein, Dirk De Bacquer, Jan Borén, Olov Wiklund, Païvi Laitinen, Wytze P Oosterhuis, Christa Cobbaert
Atherosclerosis - 2014 -
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat
diet.
Emmelie Cansby, Manoj Amrutkar, Louise Mannerås Holm, Annika Nerstedt, Azadeh Reyahi, Elin Stenfeldt, Jan Borén, Peter Carlsson, Ulf Smith, Juleen R Zierath, Margit Mahlapuu
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2013 -
COBLL1 rs7607980 genetic variant and insulin resistance in overweight and obese
children.
Rosellina Margherita Mancina, Maria Antonella Burza, Cristina Maglio, Carlo Pirazzi, Federica Sentinelli, Michela Incani, Tiziana Montalcini, Arturo Pujia, Tiziana Congiu, Sandro Loche, Sabrina Pilia, Olov Wiklund, Jan Borén, Stefano Romeo, Marco Giorgio Baroni
Diabetes/metabolism research and reviews - 2013 -
The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese
Individuals.
Cristina Maglio, Ulrika Ericson, Maria Antonella Burza, Rosellina Margherita Mancina, Carlo Pirazzi, Johanna C. Andersson-Assarsson, Kajsa Sjöholm, Marco Giorgio Baroni, Per-Arne Svensson, Tiziana Montalcini, Arturo Pujia, Lars Sjöström, Olov Wiklund, Lena M S Carlsson, Jan Borén, Marju Orho-Melander, Stefano Romeo
The Journal of clinical endocrinology and metabolism - 2013 -
Genetic Variation in SULF2 Is Associated with Postprandial Clearance of Triglyceride-Rich Remnant Particles and Triglyceride Levels in Healthy
Subjects.
Niina Matikainen, Maria Antonella Burza, Stefano Romeo, Antti Hakkarainen, Martin Adiels, Lasse Folkersen, Per Eriksson, Nina Lundbom, Ewa Ehrenborg, Marju Orho-Melander, Marja-Riitta Taskinen, Jan Borén
PloS one - 2013 -
Rapid Quantification of Yeast Lipid using Microwave-Assisted Total Lipid Extraction and
HPLC-CAD
Sakda Khoomrung, Pramote Chumnanpuen, Suwanee Jansa-Ard, Marcus Ståhlman, Intawat Nookaew, Jan Borén, Jens B. Nielsen
Analytical Chemistry - 2013 -
Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in
Mice
Omar M. Khan, Murali K Akula, Kristina Skålen, Christin Karlsson, Marcus Ståhlman, S. G. Young, Jan Borén, Martin Bergö
Circulation - 2013 -
Cadmium exposure, intercellular adhesion molecule-1 and peripheral artery disease: a cohort and an experimental
study.
Björn Fagerberg, Göran Bergström, Jan Borén, Lars Barregård
BMJ open - 2013 -
The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an alpha-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in
humans
J. Magne, A. Aminoff, Jeanna Perman Sundelin, M. N. Mannila, P. Gustafsson, K. Hultenby, A. Wernerson, G. Bauer, L. Listenberger, M. J. Neville, F. Karpe, Jan Borén, E. Ehrenborg
Faseb Journal - 2013 -
Macrophage Gene Expression in Adipose Tissue is Associated with Insulin Sensitivity and Serum Lipid Levels Independent of
Obesity.
Sofie Ahlin, Kajsa Sjöholm, Peter Jacobson, Johanna C. Andersson-Assarsson, A Walley, J Tordjman, C Poitou, E Prifti, Per-Anders Jansson, Jan Borén, Lars Sjöström, P Froguel, R N Bergman, Lena M S Carlsson, Bob Olsson, Per-Arne Svensson
Obesity (Silver Spring, Md.) - 2013 -
Treatment of hyaluronan accumulation ameliorates high-fat diet-induced insulin resistance in
mice.
Per Fogelstrand, Jan Borén
Diabetes - 2013 -
Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein e deficient
mice.
Anna Lindgren, Malin Levin, Sandra Rodrigo Blomqvist, Johannes Wikström, Andrea Ahnmark, Christina Mogensen, Gerhard Böttcher, Mohammad Bohlooly-Y, Jan Borén, Li-Ming Gan, Daniel Lindén
PloS one - 2013 -
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis
Society.
Børge G Nordestgaard, M John Chapman, Steve E Humphries, Henry N Ginsberg, Luis Masana, Olivier S Descamps, Olov Wiklund, Robert A Hegele, Frederick J Raal, Joep C Defesche, Albert Wiegman, Raul D Santos, Gerald F Watts, Klaus G Parhofer, G Kees Hovingh, Petri T Kovanen, Catherine Boileau, Maurizio Averna, Jan Borén, Eric Bruckert, Alberico L Catapano, Jan Albert Kuivenhoven, Päivi Pajukanta, Kausik Ray, Anton F H Stalenhoef, Erik Stroes, Marja-Riitta Taskinen, Anne Tybjærg-Hansen
European heart journal - 2013 -
Cholesteryl Esters Accumulate in the Heart in a Porcine Model of Ischemia and
Reperfusion
Christina Drevinge, Lars O Karlsson, Marcus Ståhlman, Thomas Larsson, Jeanna Perman Sundelin, Lars Grip, Linda Andersson, Jan Borén, Malin Levin
Plos One - 2013 -
Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: Impact on small HDL
particles
Marcus Ståhlman, Björn Fagerberg, Martin Adiels, K. Ekroos, J. M. Chapman, A. Kontush, Jan Borén
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2013 -
PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C.
elegans
Emma Svensk, Marcus Ståhlman, Carl-Henrik Andersson, Maja Johansson, Jan Borén, Marc Pilon
Plos Genetics - 2013 -
Novel rat model reveals important roles of β-adrenoreceptors in stress-induced
cardiomyopathy.
Yangzhen Shao, Björn Redfors, Margareta Scharin Täng, Helge Möllmann, Christian Troidl, Sebastian Szardien, Christian Hamm, Holger Nef, Jan Borén, Elmir Omerovic
International journal of cardiology - 2013 -
Hypoxia-induced regulation of the very low density lipoprotein
receptor
Jeanna Perman Sundelin, Ulf Lidberg, Ali Moussavi Nik, Peter Carlsson, Jan Borén
Biochemical and Biophysical Research Communications - 2013 -
Ectopic lipid storage and insulin resistance: a harmful
relationship
Jan Borén, M. R. Taskinen, Sven-Olof Olofsson, Malin Levin
Journal of Internal Medicine - 2013 -
ARF6 Regulates Neuron Differentiation through Glucosylceramide
Synthase
Lu Li, Marcus Ståhlman, Mikael Rutberg, Liliana Håversen, Per Fogelstrand, Linda Andersson, Malin Levin, Jan Borén
Plos One - 2013 -
A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced
cardiomyopathy.
Yangzhen Shao, Björn Redfors, Marcus Ståhlman, Margareta Scharin Täng, Azra Miljanovic, Helge Möllmann, Christian Troidl, Sebastian Szardien, Christian Hamm, Holger Nef, Jan Borén, Elmir Omerovic
European journal of heart failure - 2013 -
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in
vitro
Carlo Pirazzi, Martin Adiels, Maria Antonella Burza, Rosellina Margherita Mancina, Malin Levin, Marcus Ståhlman, M. R. Taskinen, M. Orho-Melander, Jeanna Perman, A. Pujia, Linda Andersson, Cristina Maglio, T. Montalcini, Olov Wiklund, Jan Borén, Stefano Romeo
Journal of Hepatology - 2012 -
Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in
Atherosclerosis
Lisa U. Magnusson, Annika Lundqvist, Merja Nurkkala Karlsson, Kristina Skålen, Max Levin, Olov Wiklund, Jan Borén, Lillemor Mattsson Hultén
Plos One - 2012 -
Effects of doxorubicin on myocardial expression of
apolipoprotein-B.
Björn Redfors, Yangzhen Shao, Truls Råmunddal, Malin Lindbom, Margareta Scharin Täng, Pia Stillemark-Billton, Jan Borén, Elmir Omerovic
Scandinavian Cardiovascular Journal - 2012 -
Kinetic Studies to Investigate Lipoprotein
Metabolism.
Jan Borén, Marja-Riitta Taskinen, Martin Adiels
Journal of internal medicine - 2012 -
Effects of doxorubicin on myocardial expression of
apolipoprotein-B.
Björn Redfors, Yangzhen Shao, Truls Råmunddal, Malin Lindbom, Margareta Scharin Täng, Pia Stillemark-Billton, Jan Borén, Elmir Omerovic
Scandinavian Cardiovascular Journal - 2012 -
Apolipoprotein B Secretory Regulation by
Degradation
Sven-Olof Olofsson, Jan Borén
Arteriosclerosis Thrombosis and Vascular Biology - 2012 -
Evaluation of macrophage-specific promoters using lentiviral delivery in
mice.
Malin Levin, Ulf Lidberg, Pernilla Jirholt, Martin Adiels, Anna Wramstedt, K Gustafsson, D R Greaves, S Li, S Fazio, M F Linton, Sven-Olof Olofsson, Jan Borén, Inger Gjertsson
Gene therapy - 2012 -
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese
individuals
Maria Antonella Burza, Carlo Pirazzi, Cristina Maglio, Kajsa Sjöholm, Rosellina Margherita Mancina, Per-Arne Svensson, Peter Jacobson, Martin Adiels, M. G. Baroni, Jan Borén, S. G. Corradini, T. Montalcini, Lars Sjöström, Lena M S Carlsson, Stefano Romeo
Digestive and Liver Disease - 2012 -
Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M
Variant
C. N. A. Palmer, Cristina Maglio, Carlo Pirazzi, Maria Antonella Burza, Martin Adiels, L. Burch, L. A. Donnelly, H. Colhoun, A. S. Doney, J. F. Dillon, E. R. Pearson, M. McCarthy, A. T. Hattersley, T. Frayling, A. D. Morris, Markku Peltonen, Per-Arne Svensson, Peter Jacobson, Jan Borén, Lars Sjöström, Lena M S Carlsson, Stefano Romeo
PLoS ONE - 2012 -
Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance
capacity.
Martin Adiels, Niina Matikainen, Jukka Westerbacka, Sanni Söderlund, Thomas Larsson, Sven-Olof Olofsson, Jan Borén, Marja-Riitta Taskinen
Atherosclerosis - 2012 -
Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2
diabetes.
Marcus Ståhlman, H T Pham, Martin Adiels, T W Mitchell, S J Blanksby, Björn Fagerberg, Kim Ekroos, Jan Borén
Diabetologia - 2012 -
Increased Expression of the Very Low-Density Lipoprotein Receptor Mediates Lipid Accumulation in Clear-Cell Renal Cell
Carcinoma
Jeanna Perman Sundelin, Marcus Ståhlman, Annika Lundqvist, Max Levin, P. Parini, Martin Johansson, Jan Borén
Plos One - 2012 -
Cadmium exposure is accompanied by increased prevalence and future growth of atherosclerotic plaques in 64-year-old
women
Björn Fagerberg, Göran Bergström, Jan Borén, Lars Barregård
Journal of Internal Medicine - 2012 -
Overexpression of apolipoprotein B attenuates pathologic cardiac remodeling and hypertrophy in response to catecholamines and after myocardial infarction in
mice.
Truls Råmunddal, Malin Lindbom, Margareta Scharin Täng, Yangzhen Shao, Jan Borén, Elmir Omerovic
Scandinavian Journal of Clinical & Laboratory Investigation - 2012 -
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in
mice
Rajesh K. Nallapalli, Mohamed X Ibrahim, Xianghua Zhou, Sashidar Bandaru, Sai Naresh Sunkara, Björn Redfors, David Pazooki, Yin Zhang, Jan Borén, Yihai Cao, Martin Bergö, Levent Akyürek
Molecular Cancer - 2012 -
The Importance of GLUT3 for De Novo Lipogenesis in Hypoxia-Induced Lipid Loading of Human
Macrophages
Lu Li, Bo Liu, Liliana Håversen, Emma Lu, Lisa U. Magnusson, Marcus Ståhlman, Jan Borén, Göran Bergström, Malin Levin, Lillemor Mattsson Hultén
Plos One - 2012 -
Electrophysiological Effects of Lysophosphatidylcholine on HL-1 Cardiomyocytes Assessed with a Microelectrode Array
System
Sigfus Gizurarson, Yangzhen Shao, Azra Miljanovic, Truls Råmunddal, Jan Borén, Lennart Bergfeldt, Elmir Omerovic
Cellular Physiology and Biochemistry - 2012 -
Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium
dynamics
Karin Åström-Olsson, Lizhen Li, Charlotta S Olofsson, Jan Borén, H. Ohlin, Lars Grip
Biochemical and Biophysical Research Communications - 2012 -
Retention of atherogenic lipoproteins in the artery wall and its role in
atherogenesis.
Per Fogelstrand, Jan Borén
Nutrition, Metabolism and Cardiovascular Diseases: NMCD - 2012 -
Rip2 deficiency leads to increased atherosclerosis despite decreased
inflammation.
Malin Levin, Pernilla Jirholt, Anna Wramstedt, Maria E Johansson, Anna M Lundberg, Maria Gustafsson Trajkovska, Marcus Ståhlman, Per Fogelstrand, Mikael Brisslert, Linda Fogelstrand, Zhong-Qun Yan, Göran K Hansson, Harry Björkbacka, Sven-Olof Olofsson, Jan Borén
Circulation research - 2011 -
Filamin A mediates HGF/c-MET signaling in tumor cell
migration.
Xianghua Zhou, Asli Toylu, Rajesh K. Nallapalli, Gisela M A Nilsson, Nese Atabey, Carl-Henrik Heldin, Jan Borén, Martin Bergö, Levent Akyürek
International journal of cancer. Journal international du cancer - 2011 -
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial
infarction.
Jeanna Perman, Pontus Boström, Malin Lindbom, Ulf Lidberg, Marcus Ståhlman, Daniel Hägg, Henrik Lindskog, Margareta Scharin Täng, Elmir Omerovic, Lillemor Mattsson Hultén, Anders Jeppsson, Petur Petursson, Johan Herlitz, Gunilla Olivecrona, Dudley K Strickland, Kim Ekroos, Sven-Olof Olofsson, Jan Borén
The Journal of clinical investigation - 2011 -
The formation of lipid droplets: possible role in the development of insulin resistance/type 2
diabetes.
Sven-Olof Olofsson, Linda Andersson, Liliana Håversen, Kristina Olsson, Susanna Myhre, Mikael Rutberg, Reza Mobini, Lu Li, Emma Lu, Jan Borén, Pontus Boström
Prostaglandins, leukotrienes, and essential fatty acids - 2011 -
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for
management
MJ Chapman, HN Ginsberg, P Amarenco, F Andreotti, Jan Borén, AL Catapano, OS Descamps, E Fisher, PT Kovanen, JA Kuivenhoven, P Lesnik, L Masana, BG Nordestgaard, KK Ray, Z Reiner, MR Taskinen, L Tokgozoglu, A Tybjaerg-Hansen, GF Watts
EUROPEAN HEART JOURNAL - 2011 -
Dietary alpha-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven
inflammation
S Winnik, C Lohmann, EK Richter, N Schafer, WL Song, F Leiber, P Mocharla, J Hofmann, R Klingenberg, Jan Borén, B Becher, GA FitzGerald, TF Luscher, CM Matter, JH Beer
EUROPEAN HEART JOURNAL - 2011 -
Deletion of L-Selectin Increases Atherosclerosis Development in ApoE(-/-)
Mice
I Rozenberg, SHM Sluka, P Mocharla, A Hallenberg, P Rotzius, Jan Borén, N Krankel, U Landmesser, L Borsig, TF Luscher, EE Eriksson, FC Tanner
PLOS ONE - 2011 -
Postnatal essential fatty acid deficiency in mice affects lipoproteins, hepatic lipids, fatty acids and mRNA
expression
Vilborg Palsdottir, Bob Olsson, Jan Borén, Birgitta Strandvik, Britt G. Gabrielsson
Prostaglandins, Leukotrienes and Essential Fatty Acids - 2011 -
LDL-associated apolipoprotein J and lysozyme are associated with atherogenic properties of LDL found in type 2 diabetes and the metabolic
syndrome.
Camilla Pettersson, H Karlsson, Marcus Ståhlman, Thomas Larsson, Björn Fagerberg, Mats Lindahl, Olov Wiklund, Jan Borén, Linda Fogelstrand
Journal of internal medicine - 2011 -
Dual metabolic defects are required to produce hypertriglyceridemia in obese
subjects.
Marja-Riitta Taskinen, Martin Adiels, Jukka Westerbacka, Sanni Söderlund, Juhani Kahri, Nina Lundbom, Jesper Lundbom, Antti Hakkarainen, Sven-Olof Olofsson, Marju Orho-Melander, Jan Borén
Arteriosclerosis, thrombosis, and vascular biology - 2011 -
Establishment of a transgenic mouse model specifically expressing human serum amyloid a in adipose
tissue.
Maja Olsson, Sofie Ahlin, Bob Olsson, Per-Arne Svensson, Marcus Ståhlman, Jan Borén, Lena M S Carlsson, Kajsa Sjöholm
PloS one - 2011 -
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in
vitro.
Fei Tian, Xianghua Zhou, Anke M Smits, Erik Larsson, Marie-José Goumans, Carl-Henrik Heldin, Jan Borén, Levent Akyürek
Biochemical and Biophysical Research Communications - 2010 -
Allele-specific regulation of MTTP expression influences the risk of ischemic heart
disease.
A Aminoff, H Ledmyr, P Thulin, K Lundell, Leyla Nunez, Elisabeth Strandhagen, C Murphy, Ulf Lidberg, Jukka Westerbacka, A Franco-Cereceda, J Liska, LB Nielsen, M Gåfvels, M Nastase Mannila, Anders Hamsten, Hannele Yki-Järvinen, Dag Thelle, Per Eriksson, Jan Borén, E Ehrenborg
Journal of lipid research - 2010 -
Lipoprotein(a) as a Cardiovascular Risk Factor: Current
Status
B. G. Nordestgaard, MJ Chapman, K Ray, Jan Borén, F Andreotti, GF Watts, Mark H Ginsberg, P Amarenco, OS Descamps, E Fisher, PT Kovanen, JA Kuivenhoven, P Lesnik, L Masana, Z Reiner, Marja-Riitta Taskinen, Lale Tokgözoglu, A. Tybjaerg-Hansen
European Heart Journal - 2010 -
SIRT1 decreases Lox-1-mediated foam cell formation in
atherogenesis.
Stein Stein, Christine Lohmann, Nicola Schäfer, Janin Hofmann, Lucia Rohrer, Christian Besler, Karin M Rothgiesser, Burkhard Becher, Michael O Hottiger, Jan Borén, Michael W McBurney, Ulf Landmesser, Thomas F Lüscher, Christian M Matter
European heart journal - 2010 -
Levosimendan neither improves nor worsens mortality in patients with cardiogenic shock due to ST-elevation myocardial
infarction.
Elmir Omerovic, Truls Råmunddal, Per Albertsson, Mikael Holmberg, Per Hallgren, Jan Borén, Lars Grip, Göran Matejka
Vascular health and risk management - 2010 -
15-Lipoxygenase-2 is expressed in macrophages in human carotid plaques and regulated by hypoxia-inducible factor-1
alpha
Lillemor Mattsson Hultén, Fredrik J. Olson, Hanna Åberg, Jonas Carlsson, Lars Karlström, Jan Borén, Björn Fagerberg, Olov Wiklund
European Journal of Clinical Investigation - 2010 -
The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2
diabetes.
Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, M.K Svensson, Rickard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Diabetes - 2010 -
Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density
lipoproteins.
I. Rozenberg, Susanna H M Sluka, Lucia Rohrer, Janin Hofmann, B. Becher, A. Akhmedov, Jorge Soliz, Pavani Mocharla, Jan Borén, Pål Johansen, Jan Steffel, Takeshi Watanabe, Thomas F Lüscher, Felix C Tanner
Arteriosclerosis, thrombosis, and vascular biology - 2010 -
Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density
lipoproteins.
Martin Adiels, Thomas Larsson, Pauline Sutton, Marja-Riitta Taskinen, Jan Borén, Barbara A Fielding
Rapid communications in mass spectrometry : RCM - 2010 -
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced
obesity.
Damir Zadravec, Annelie Brolinson, Rachel M Fisher, Claes Carneheim, Robert I Csikasz, Justine Bertrand-Michel, Jan Borén, Hervé Guillou, Mats Rudling, Anders Jacobsson
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2010 -
ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced
atherosclerosis.
Sokrates Stein, Christine Lohmann, Christoph Handschin, Elin Stenfeldt, Jan Borén, Thomas F Lüscher, Christian M Matter
PloS one - 2010 -
The gut microbiota modulates host energy and lipid metabolism in
mice
Vidya R. Velagapudi, Rahil Hezaveh, Christopher S. Reigstad, Peddinti V. Gopalacharyulu, Laxman Yetukuri, Sama Islam, Jenny Felin, Rosie Perkins, Jan Borén, Matej Oresic, Fredrik Bäckhed
Journal of Lipid Research - 2009 -
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in
angiogenesis.
Fei Tian, Xianghua Zhou, Johannes Wikström, Helen Karlsson, Helen Sjöland, Li-Ming Gan, Jan Borén, Levent Akyürek
American Journal of Physiology. Heart and Circulatory Physiology - 2009 -
CD44-deficiency on hematopoietic cells limits T-cell number but does not protect against atherogenesis in LDL receptor-deficient
mice.
Sara Sjöberg, EE Eriksson, Åsa Tivesten, Annelie Carlsson, A Klasson, Max Levin, Jan Borén, Alexandra Krettek
Atherosclerosis - 2009 -
A brief review of lipoprotein
metabolism
Martin Adiels, Sven-Olof Olofsson, Marja-Riitta Taskinen, Jan Borén
Evidence-Based Management of Lipid Disorders - 2009 -
High-throughput shotgun lipidomics by quadrupole time-of-flight mass
spectrometry.
Marcus Ståhlman, CS Ejsing, K Tarasov, Jeanna Perman, Jan Borén, K Ekroos
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences - 2009 -
Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic
islets.
C Lohmann, N Schäfer, Tobias von Lukowicz, MA Sokrates Stein, Jan Borén, S Rütti, W Wahli, MY Donath, TF Lüscher, CM Matter
Atherosclerosis - 2009 -
Overexpression of apolipoprotein-B improves cardiac function and increases survival in mice with myocardial
infarction.
Truls Råmunddal, Malin Lindbom, Margareta Scharin Täng, Pia Stillemark-Billton, Jan Borén, Elmir Omerovic
Biochemical and biophysical research communications - 2009 -
ApoCIII-Enriched LDL in Type 2 Diabetes Displays Altered Lipid Composition, Increased Susceptibility for Sphingomyelinase and Increased binding to
Biglycan.
A Hiukka, Marcus Ståhlman, Camilla Pettersson, Malin Levin, Martin Adiels, Susann Teneberg, ES Leinonen, Lillemor Mattsson Hultén, Olov Wiklund, M Oresic, Sven-Olof Olofsson, MR Taskinen, K Ekroos, Jan Borén
Diabetes - 2009 -
The Lipid Droplet: a Dynamic Organelle, not only Involved in the Storage and Turnover of
Lipids
Sven-Olof Olofsson, Pontus Boström, Jens O. Lagerstedt, Linda Andersson, Martin Adiels, Jeanna Perman, Mikael Rutberg, Lu Li, Jan Borén
Cellular Lipid Metabolism - 2009 -
Rekrytering av medicinare till forskning kräver tidigt engagemang. Amanuensprogram visar att tidig forskningsstart ger bättre
resultat.
Jan Borén, Martin Adiels, Ylva Wickström, Sven-Olof Olofsson, Pontus Boström
Läkartidningen - 2009 -
BASELINE apoB-100 AND TRIGLYCERIDE KINETICS PREDICTS POSTPRANDIAL TRIGLYCERIDE AND apoB-48 ACCUMULATION IN CHYLOMICRON, VLDL1 AND VLDL2
FRACTIONS
Martin Adiels, Niina Matikainen, Jukka Westerbacka, S Soderlund, Jan Borén, Marja-Riitta Taskinen
XV International Symposium on Atherosclerosis - 2009 -
The assembly of lipid droplets and its relation to cellular insulin
sensitivity.
Pontus Boström, Linda Andersson, Lu Li, Rosie Perkins, Kurt Højlund, Jan Borén, Sven-Olof Olofsson
Biochemical Society transactions - 2009 -
c-Jun N-terminal kinase 2 deficiency protects against hypercholesterolemia-induced endothelial dysfunction and oxidative
stress
E. Osto, C. M. Matter, A. Kouroedov, T. Malinski, M. Bachschmid, G.G. Camici, U. Kilic, T. Stallmach, Jan Borén, S. Iliceto, T.F. Lüscher, F. Cosentino
Circulation - 2008 -
Fatty liver, insulin resistance, and
dyslipidemia.
Martin Adiels, Marja-Riitta Taskinen, Jan Borén
Current diabetes reports - 2008 -
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell
migration.
Kristina Danielsson Norén, Ellen Rydberg Knutsen, Madeleine Ingelsten, Levent Akyürek, Pernilla Jirholt, Christina Ullström, Gun-Britt Forsberg, Jan Borén, Olov Wiklund, Lillemor Mattsson Hultén
Atherosclerosis - 2008 -
ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition and increased susceptibility for
sphingomyelinase
Anne Hiukka, Marcus Ståhlman, Camilla Pettersson, Malin Levin, Martin Adiels, Susann Teneberg, Olov Wiklund, Matej Oresic, Sven-Olof Olofsson, Marja-Riitta Taskinen, Kim Ekroos, Jan Borén
CHEMISTRY AND PHYSICS OF LIPIDS - 2008 -
Triglyceride containing lipid droplets and lipid droplet-associated
proteins.
Sven-Olof Olofsson, Pontus Boström, Linda Andersson, Mikael Rutberg, Malin Levin, Jeanna Perman, Jan Borén
Current opinion in lipidology - 2008 -
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive
population.
Anna Benrick, Pernilla Jirholt, Ingrid Wernstedt, Maria Gustafsson, Juergen Scheller, Anna-Lena Eriksson, Jan Borén, Thomas Hedner, Claes Ohlsson, Torleif Härd, Stefan Rose-John, John-Olov Jansson
Regulatory peptides - 2008 -
Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell
proliferation.
Karin Tran-Lundmark, Phan-Kiet Tran, Gabrielle Paulsson-Berne, Vincent Fridén, Raija Soininen, Karl Tryggvason, Thomas N Wight, Michael G Kinsella, Jan Borén, Ulf Hedin
Circulation research - 2008 -
Proteomics and lipids of lipoproteins isolated at low salt concentrations in D2O/sucrose or in
KBr.
Marcus Ståhlman, Pia Davidsson, Ida Kanmert, Birgitta Rosengren, Jan Borén, Björn Fagerberg, German Camejo
Journal of lipid research - 2008 -
Lipid droplets as dynamic organelles connecting storage and efflux of
lipids.
Sven-Olof Olofsson, Pontus Boström, Linda Andersson, Mikael Rutberg, Jeanna Perman, Jan Borén
Biochimica et biophysica acta - 2008 -
Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic
syndrome.
Martin Adiels, Sven-Olof Olofsson, Marja-Riitta Taskinen, Jan Borén
Arteriosclerosis, thrombosis, and vascular biology - 2008 -
Disturbed cholesterol homeostasis in hormone-sensitive lipase-null
mice.
Céline Fernandez, Marie Lindholm, Morten Krogh, Stéphanie Lucas, Sara Larsson, Peter Osmark, Karin Berger, Jan Borén, Barbara Fielding, Keith Frayn, Cecilia Holm
American journal of physiology. Endocrinology and metabolism - 2008 -
Visceral Adiposity, Liver Fat, and Atherogenic
Dyslipidemia
Marja-Riitta Taskinen, Martin Adiels, Jan Borén
Abdominal Obesity and the Endocannabinoid System: From Basic Aspects to Clinical Management of Related Cardiometabolic Risk - 2008 -
PARP1 is required for adhesion molecule expression in
atherogenesis.
Tobias von Lukowicz, Paul O Hassa, Christine Lohmann, Jan Borén, Vincent Braunersreuther, François Mach, Bernhard Odermatt, Monika Gersbach, Giovanni G Camici, Barbara E Stähli, Felix C Tanner, Michael O Hottiger, Thomas F Lüscher, Christian M Matter
Cardiovascular research - 2008 -
Filamins in cardiovascular
development.
Xianghua Zhou, Jan Borén, Levent Akyürek
Trends in Cardiovascular Medicine - 2007 -
The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient
mice
Johan Bourghardt Fagman, Göran Bergström, Alexandra Krettek, Sara Sjöberg, Jan Borén, Åsa Tivesten
Endocrinology - 2007 -
SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin
sensitivity
Bengt R Johansson, Linda Andersson, Mikael Rutberg, Jeanna Perman, Ulf Lidberg, Johanna Ericson, Jan Borén, Sven-Olof Olofsson, Julia Fernandez-Rodriguez, Tommy Nilsson
Nature Cell Biology - 2007 -
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular
development
Xianghua Zhou, Fei Tian, Johan Sandzen, R. Cao, E. Flaberg, L. Szekely, Y. Cao, Claes Ohlsson, Martin Bergö, Jan Borén, Levent Akyürek
Proc Natl Acad Sci U S A - 2007 -
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback
loop?
Daniel Hägg, Sara Sjöberg, Lillemor Mattsson Hultén, Björn Fagerberg, Olov Wiklund, Annika Rosengren, Lena M S Carlsson, Jan Borén, Per-Arne Svensson, Alexandra Krettek
Atherosclerosis - 2007 -
Retention of Low-Density Lipoprotein in Atherosclerotic Lesions of the Mouse. Evidence for a Role of Lipoprotein
Lipase
Maria Gustafsson, Malin Levin, Kristina Skålen, Jeanna Perman, Vincent Fridén, Pernilla Jirholt, Sven-Olof Olofsson, S. Fazio, M. F. Linton, C. F. Semenkovich, G. Olivecrona, Jan Borén
Circ Res - 2007 -
SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin
sensitivity.
Pontus Boström, Linda Andersson, Mikael Rutberg, Jeanna Perman, Ulf Lidberg, Bengt R Johansson, Julia Fernandez-Rodriguez, Johanna Ericson, Tommy Nilsson, Jan Borén, Sven-Olof Olofsson
Nature cell biology - 2007 -
[A research assistant program in Gothenburg refutes the myth about medical students' lack of interest in
research]
Pontus Boström, Sven-Olof Olofsson, Jan Borén, Olle Isaksson
Lakartidningen - 2007 -
Liver fat influences both the baseline production – and the acute regulation of VLDL1 triglycerides (TG) and
apoB
Martin Adiels, Marja-Riitta Taskinen, Jan Borén
13rdAnnual Scandinavian Atherosclerosis Conference - 2007 -
Subendothelial lipoprotein retention as the initiating process in atherosclerosis - Update and therapeutic
implications
Ira Tabas, Kevin Jon Williams, Jan Borén
CIRCULATION - 2007 -
Acute suppression of VLDL(1) secretion rate by insulin is associated with hepatic fat content and insulin
resistance
Martin Adiels, J. Westerbacka, A. Soro-Paavonen, A. M. Hakkinen, S. Vehkavaara, M. J. Caslake, C. Packard, Sven-Olof Olofsson, H. Yki-Jarvinen, M. R. Taskinen, Jan Borén
Diabetologia - 2007 -
Liver Fat Influences both the Baseline Production- and the Acute Regulation of VLDL1 TG and
apoB
Martin Adiels, Jukka Westerbacka, A. Soro-Paavonen, A-M Haakinen, S. Vehkavaara, M. J. Caslake, C. Packard, Sven-Olof Olofsson, Hannele Yki-Järvinen, Marja-Riitta Taskinen, Jan Borén
ATHEROSCLEROSIS SUPPLEMENTS - 2007 -
Apolipoproteins A-I and B: biosynthesis, role in the development of atherosclerosis and targets for intervention against cardiovascular
disease.
Sven-Olof Olofsson, Olov Wiklund, Jan Borén
Vascular health and risk management - 2007 -
Endothelial dysfunction in growth hormone transgenic
mice
Irene Andersson, Maria E Johansson, Anna Wickman, Mohammad Bohlooly-Yeganeh, Natalia Klintland, Kenneth Caidahl, Maria Gustafsson, Jan Borén, Li-Ming Gan, Göran Bergström
Clinical Science - 2006 -
Hypoxia converts human macrophages into triglyceride-loaded foam
cells.
Pontus Boström, Björn Magnusson, Per-Arne Svensson, Olov Wiklund, Jan Borén, Lena M S Carlsson, Marcus Ståhlman, Sven-Olof Olofsson, Lillemor Mattsson Hultén
Arteriosclerosis, thrombosis, and vascular biology - 2006 -
Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100
VLDL
Lu Li, Pia Stillemark-Billton, Caroline Beck, Pontus Boström, Linda Andersson, Mikael Rutberg, Johanna Ericsson, Björn Magnusson, Denis Marchesan, Anna Ljungberg, Jan Borén, Sven-Olof Olofsson
J Lipid Res - 2006 -
Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density
lipoproteins
Björn Magnusson, Lennart Asp, Pontus Boström, M. Ruiz, Pia Stillemark-Billton, D. Linden, Jan Borén, Sven-Olof Olofsson
Arterioscler Thromb Vasc Biol - 2006 -
Pathogenesis and treatment of diabetic vascular disease - illustrated by two
cases
Ulf Smith, M. Laakso, Björn Eliasson, Christian Wesslau, Jan Borén, Olov Wiklund, Stig Attvall
J Intern Med - 2006 -
Diabetic
dyslipidaemia
Martin Adiels, Sven-Olof Olofsson, M. R. Taskinen, Jan Borén
Curr Opin Lipidol - 2006 -
Overproduction of large VLDL particles is driven by increased liver fat content in
man
Martin Adiels, M. R. Taskinen, C. Packard, M. J. Caslake, A. Soro-Paavonen, J. Westerbacka, S. Vehkavaara, A. Hakkinen, Sven-Olof Olofsson, H. Yki-Jarvinen, Jan Borén
Diabetologia - 2006 -
PLD1 and ERK2 regulate cytosolic lipid droplet
formation
Linda Andersson, Pontus Boström, Johanna Ericson, Mikael Rutberg, Björn Magnusson, Denis Marchesan, Michelle Ruiz, Lennart Asp, Peang Huang, Michael Frohman, Jan Borén, Sven-Olof Olofsson
J Cell Sci - 2006 -
ATP depletion in macrophages in the core of advanced rabbit atherosclerotic plaques in
vivo
Olli Leppanen, Tom Björnheden, Margareta Evaldsson, Jan Borén, Olov Wiklund, Max Levin
Atherosclerosis - 2006 -
In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal
cells
Jan Borén, A. Ramos-Montoya, K. S. Bosch, H. Vreeling, A. Jonker, J. J. Centelles, M. Cascante, W. M. Frederiks
J Histochem Cytochem - 2006 -
Postnatal constriction, ATP depletion, and cell death in the mature and immature ductus
arteriosus
Max Levin, D. McCurnin, S. R. Seidner, B. Yoder, N. Waleh, S. Goldbarg, C. Roman, B. M. Liu, Jan Borén, R. I. Clyman
Am J Physiol Regul Integr Comp Physiol - 2006 -
A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL
subfractions
Martin Adiels, C. Packard, M. J. Caslake, P. Stewart, A. Soro, J. Westerbacka, Bernt Wennberg, Sven-Olof Olofsson, M. R. Taskinen, Jan Borén
J Lipid Res - 2005 -
Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic
dyslipidemia
Martin Adiels, Jan Borén, M. J. Caslake, P. Stewart, Aina Soro, J. Westerbacka, Bernt Wennberg, Sven-Olof Olofsson, C. Packard, M. R. Taskinen
Arterioscler Thromb Vasc Biol - 2005 -
Diverse origin of vascular smooth muscle cells in the
neointima
Xianghua Zhou, Caroline Beck, Jan Borén, Levent Akyürek
Anadolu Kardiyol Derg - 2005 -
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL
2
Pia Stillemark-Billton, Caroline Beck, Jan Borén, Sven-Olof Olofsson
J Lipid Res - 2005 -
ATP depletion and cell death in the neonatal lamb ductus
arteriosus
Max Levin, S. Goldbarg, A. Lindqvist, K. Sward, C. Roman, B. M. Liu, Lillemor Mattsson Hultén, Jan Borén, R. I. Clyman
Pediatr Res - 2005 -
Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement
system.
Linda Persson, Jan Borén, A. Nicoletti, G. K. Hansson, Marcela Pekna
Clinical and experimental immunology - 2005 -
Cytosolic lipid droplets increase in size by microtubule-dependent complex
formation
Pontus Boström, Mikael Rutberg, Johanna Ericsson, P. Holmdahl, Linda Andersson, M. A. Frohman, Jan Borén, Sven-Olof Olofsson
Arterioscler Thromb Vasc Biol - 2005 -
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of
atherosclerosis
Sven-Olof Olofsson, Jan Borén
J Intern Med - 2005 -
Role of ADP ribosylation factor 1 in the assembly and secretion of ApoB-100-containing
lipoproteins
Lennart Asp, Björn Magnusson, Mikael Rutberg, Lu Li, Jan Borén, Sven-Olof Olofsson
Arterioscler Thromb Vasc Biol - 2005 -
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future
challenges
Caroline Beck, Hidetaka Uramoto, Jan Borén, Levent Akyürek
Current Gene Therapies - 2004 -
Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/-
mice
Linda Persson, Jan Borén, A. K. Robertson, Ville Wallenius, G. K. Hansson, Marcela Pekna
Arterioscler Thromb Vasc Biol - 2004 -
Retention of atherogenic lipoproteins in
atherogenesis
Maria Gustafsson, Christofer Flood, Pernilla Jirholt, Jan Borén
Cell Mol Life Sci - 2004 -
How does mutant proprotein convertase neural apoptosis-regulated convertase 1 induce autosomal dominant
hypercholesterolemia?
Pernilla Jirholt, Martin Adiels, Jan Borén
Arterioscler Thromb Vasc Biol - 2004 -
Dermal absorption of camphor, menthol, and methyl salicylate in
humans
D. Martin, J. Valdez, Jan Borén, M. Mayersohn
J Clin Pharmacol - 2004 -
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in
atherogenesis
R. Ricci, G. Sumara, I. Sumara, I. Rozenberg, M. Kurrer, A. Akhmedov, M. Hersberger, U. Eriksson, F. R. Eberli, B. Becher, Jan Borén, M. Chen, M. I. Cybulsky, K. J. Moore, M. W. Freeman, E. F. Wagner, C. M. Matter, T. F. Luscher
Science - 2004 -
Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein
B100
Christofer Flood, Maria Gustafsson, R. E. Pitas, L. Arnaboldi, R. L. Walzem, Jan Borén
Arterioscler Thromb Vasc Biol - 2004 -
Mechanism of lipoprotein retention by the extracellular
matrix
Maria Gustafsson, Jan Borén
Curr Opin Lipidol - 2004 -
Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor
treatment
W. N. Lee, P. Guo, S. Lim, S. Bassilian, S. T. Lee, Jan Borén, M. Cascante, V. L. Go, L. G. Boros
Br J Cancer - 2004 -
A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free
system.
Denis Marchesan, Mikael Rutberg, Linda Andersson, Lennart Asp, Thomas Larsson, Jan Borén, Bengt R Johansson, Sven-Olof Olofsson
Journal of Biological Chemistry - 2003 -
Expression of scavenger receptor class B type I in gallbladder columnar
epithelium.
Magnus S.C. Johnson, Per-Arne Svensson, Jan Borén, Håkan Billig, Lena M S Carlsson, Björn Carlsson
Journal of gastroenterology and hepatology - 2002 -
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and
ApoB-48.
Daniel Lindén, Karin Lindberg, Jan Oscarsson, Lennart Asp, Lu Li, Maria Gustafsson, Jan Borén, Sven-Olof Olofsson
The Journal of biological chemistry - 2002